PSMD7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMD7_MOUSE
• UniProt AC: P26516
• Protein Name: 26S proteasome non-ATPase regulatory subunit 7
• Gene Name: Psmd7
• Organism: Mus musculus (Mouse).
• Sequence Length: 321
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
• Protein Sequence: MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVASGKLPINHQIIYQLQDVFNLLPDASLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKERKDDKEKEKSDAAKKEEKKEKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Ubiquitination	VLLGSWQKKVLDVSN EEECHHHHHEECCCC		-
45	Succinylation	VLLGSWQKKVLDVSN EEECHHHHHEECCCC		23806337
45	Acetylation	VLLGSWQKKVLDVSN EEECHHHHHEECCCC		23806337
46	Ubiquitination	LLGSWQKKVLDVSNS EECHHHHHEECCCCC		-
79	Phosphorylation	HDYLENMYGMFKKVN HHHHHHHHHHHHHCC		22817900
100	Ubiquitination	GWYHTGPKLHKNDIA EEEECCCCCCCCCHH		-
103	Ubiquitination	HTGPKLHKNDIAINE ECCCCCCCCCHHHHH		-
116	S-palmitoylation	NELMKRYCPNSVLVI HHHHHHHCCCCEEEE		26165157
135	Phosphorylation	PKDLGLPTEAYISVE HHHCCCCCEEEEEEE		30635358
138	Phosphorylation	LGLPTEAYISVEEVH CCCCCEEEEEEEEEC		30635358
140	Phosphorylation	LPTEAYISVEEVHDD CCCEEEEEEEEECCC		30635358
149	Phosphorylation	EEVHDDGTPTSKTFE EEECCCCCCCCHHHC		30635358
151	Phosphorylation	VHDDGTPTSKTFEHV ECCCCCCCCHHHCHH		30635358
152	Phosphorylation	HDDGTPTSKTFEHVT CCCCCCCCHHHCHHH		30635358
180	Ubiquitination	EHLLRDIKDTTVGTL HHHHHHCCCCCHHHH		-
186	Phosphorylation	IKDTTVGTLSQRITN CCCCCHHHHHHHHHH		29514104
199	Malonylation	TNQVHGLKGLNSKLL HHHHCCCCCCCHHHH		26320211
199	Ubiquitination	TNQVHGLKGLNSKLL HHHHCCCCCCCHHHH		-
204	Malonylation	GLKGLNSKLLDIRSY CCCCCCHHHHHHHHH		26320211
204	Ubiquitination	GLKGLNSKLLDIRSY CCCCCCHHHHHHHHH		-
204	Acetylation	GLKGLNSKLLDIRSY CCCCCCHHHHHHHHH		23236377
214	Acetylation	DIRSYLEKVASGKLP HHHHHHHHHHCCCCC		22826441
279	Acetylation	LHNLINNKIANRDAE HHHHHHHCHHCCHHH		22826441
279	Ubiquitination	LHNLINNKIANRDAE HHHHHHHCHHCCHHH		-
293	Acetylation	EKKEGQEKEESKKER HHHHHHHHHHHHHHH		15607979
297	Acetylation	GQEKEESKKERKDDK HHHHHHHHHHHHHHH		15607987
313	Acetylation	KEKSDAAKKEEKKEK HHHHHHHHHHHHHHH		23576753
314	Acetylation	EKSDAAKKEEKKEKK HHHHHHHHHHHHHHC		23576753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMD7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMD7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMD7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PSMD7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.