CAZA1_MOUSE - dbPTM
CAZA1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAZA1_MOUSE
UniProt AC P47753
Protein Name F-actin-capping protein subunit alpha-1
Gene Name Capza1
Organism Mus musculus (Mouse).
Sequence Length 286
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions..
Protein Sequence MADFEDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQFTPVKIEGYDDQVLITEHGDLGNSRFLDPRNQISFKFDHLRKEASDPQPEDVDGGLKSWRESCDSALRAYVKDHYSNGFCTVYAKTIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPSAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSVTVSNEVQTTKEFIKIIESAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MADFEDRVS
------CCCHHHCCC		30.14-
9PhosphorylationADFEDRVSDEEKVRI
CCHHHCCCHHHHHHH		39.9526824392
19AcetylationEKVRIAAKFITHAPP
HHHHHHHHHHHCCCC		28.4223806337
19UbiquitinationEKVRIAAKFITHAPP
HHHHHHHHHHHCCCC		28.42-
63PhosphorylationQYNMDQFTPVKIEGY
HCCHHHCCCEEEECC		22.8729550500
95PhosphorylationLDPRNQISFKFDHLR
CCCCCCEEEEHHHHH		16.7822942356
97AcetylationPRNQISFKFDHLRKE
CCCCEEEEHHHHHHC		42.9923806337
126PhosphorylationSWRESCDSALRAYVK
HHHHHHHHHHHHHHH		33.2628464351
198PhosphorylationVLKIQVHYYEDGNVQ
EEEEEEEEEECCCEE		15.08-
239PhosphorylationIESAENEYQTAISEN
HHHHHHHHHHHHHHH		23.8130635358
241PhosphorylationSAENEYQTAISENYQ
HHHHHHHHHHHHHCC		25.6730635358
244PhosphorylationNEYQTAISENYQTMS
HHHHHHHHHHCCCCC		19.8230635358
247PhosphorylationQTAISENYQTMSDTT
HHHHHHHCCCCCHHH		10.9930635358
249PhosphorylationAISENYQTMSDTTFK
HHHHHCCCCCHHHHH		14.3130635358
251PhosphorylationSENYQTMSDTTFKAL
HHHCCCCCHHHHHHH		34.8830635358
253PhosphorylationNYQTMSDTTFKALRR
HCCCCCHHHHHHHHH		27.1630635358
254PhosphorylationYQTMSDTTFKALRRQ
CCCCCHHHHHHHHHH		28.2930635358
268UbiquitinationQLPVTRTKIDWNKIL
HCCCCCCEECHHHHH		35.06-
268MalonylationQLPVTRTKIDWNKIL
HCCCCCCEECHHHHH		35.0626320211
273UbiquitinationRTKIDWNKILSYKIG
CCEECHHHHHHHHCH		40.55-
273AcetylationRTKIDWNKILSYKIG
CCEECHHHHHHHHCH		40.5522826441
277PhosphorylationDWNKILSYKIGKEMQ
CHHHHHHHHCHHHHC		11.8129514104
278UbiquitinationWNKILSYKIGKEMQN
HHHHHHHHCHHHHCC		41.42-
278AcetylationWNKILSYKIGKEMQN
HHHHHHHHCHHHHCC		41.4223236377
278MalonylationWNKILSYKIGKEMQN
HHHHHHHHCHHHHCC		41.4226320211
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAZA1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAZA1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAZA1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DCTN6_HUMANDCTN6physical
20360068
WAC2A_HUMANFAM21Aphysical
20360068
WASC4_HUMANKIAA1033physical
20360068
ARP10_HUMANACTR10physical
20360068
ACTY_HUMANACTR1Bphysical
20360068
CD2AP_HUMANCD2APphysical
20360068
WASC5_HUMANKIAA0196physical
20360068
WAC2C_HUMANFAM21Cphysical
20360068
DCTN4_HUMANDCTN4physical
20360068
SH3K1_HUMANSH3KBP1physical
20360068
CNOT1_HUMANCNOT1physical
20360068
DCTN1_HUMANDCTN1physical
20360068
TB182_HUMANTNKS1BP1physical
20360068
ACTZ_HUMANACTR1Aphysical
20360068
MTCL1_HUMANMTCL1physical
20360068
DCTN2_HUMANDCTN2physical
20360068
DCTN3_HUMANDCTN3physical
20360068
CARL1_HUMANLRRC16Aphysical
20360068
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAZA1_MOUSE

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Related Literatures of Post-Translational Modification

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