WAC2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WAC2A_HUMAN
• UniProt AC: Q641Q2
• Protein Name: WASH complex subunit 2A {ECO:0000312|HGNC:HGNC:23416}
• Gene Name: WASHC2A {ECO:0000312|HGNC:HGNC:23416}
• Organism: Homo sapiens (Human).
• Sequence Length: 1341
• Subcellular Localization: Early endosome membrane . Cell membrane .
• Protein Description: Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, SDCCAG3, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1, CCDC93 and C16orf62. Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells (By similarity)..
• Protein Sequence: MMNRTTPDQELAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNDFLMLSNTQFIENRVYDEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANGRVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDTEEEKEEEESDEDFAHHSDNEQNRHTTQMSDEEEDDDGCDLFADSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGDAVGRVDEEPTTLPSGEAKPRKTLKEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGLFSGGKGLFDDEDEESDLFTEAPQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFGAASVPSMKEPQKPEQPTPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTGKVQSTADIFGDEEGDLFKEKAVASPEATVSQTDENKARAEKKVTLSSSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASKLKGASLLPGKLPTLVSLFDDEDEEDNLFGGTAAKKQTLCLQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDEEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAQLGVKSVDKKVESAKESLKFGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNIIQAPQKEVGKGRDPDAHPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKTKLLEPSVGSLFGDDEDDDLFSSAKSQPLVQEKKRVVKKDHSVDSFKNQKHPESIQGSKEKGIWKPETPQDSSGLAPFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADGAISPNGHRPQLRAASGEDSTEEALAAAAAPWEGGPVPGVDRSPFAKSLGHSRGEADLFDSGDIFSTGTGSQSVERTKPKAKIAENPANPPVGGKAKSPMFPALGEASSDDDLFQSAKPKPAKKTNPFPLLEDEDDLFTDQKVKKNETKSNSQQDVILTTQDIFEDDIFATEAIKPSQKTREKEKTLESNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDMDDIFSSGIQAKTTKPKSRSAQAAPEPRFEHKVSNIFDDPLNAFGGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MMNRTTPDQELA ---CCCCCCCCCCCC		23663014
6	Phosphorylation	--MMNRTTPDQELAP --CCCCCCCCCCCCC		25159151
15	Phosphorylation	DQELAPASEPVWERP CCCCCCCCCCCCCCC		26074081
24	Phosphorylation	PVWERPWSVEEIRRS CCCCCCCCHHHHHHH		27080861
31	Phosphorylation	SVEEIRRSSQSWSLA CHHHHHHHCCHHHHH		27251275
32	Phosphorylation	VEEIRRSSQSWSLAA HHHHHHHCCHHHHHH		27251275
34	Phosphorylation	EIRRSSQSWSLAADA HHHHHCCHHHHHHHH		27251275
63	Ubiquitination	SRTHEIKKQVDGLIR HCHHHHHHHHCHHHH		-
100	Phosphorylation	QFIENRVYDEEVEEP CHHHCCCCCHHCCCC		29978859
110	Ubiquitination	EVEEPVLKAEAEKTE HCCCCHHHHHHHHHH		-
110 (in isoform 1)	Ubiquitination	-		21906983
110 (in isoform 2)	Ubiquitination	-		21906983
125	Ubiquitination	QEKTREQKEVDLIPK HHHHHHHHHHCHHHH		-
139	Phosphorylation	KVQEAVNYGLQVLDS HHHHHHHHHHHHHHH		28674151
158	Phosphorylation	LDIKAGNSDSEEDDA CCCCCCCCCCCCCCC		29255136
160	Phosphorylation	IKAGNSDSEEDDANG CCCCCCCCCCCCCCC		29255136
179	Phosphorylation	ILEPKDLYIDRPLPY EECCHHCCCCCCHHH		20068231
205	Phosphorylation	DVGLGELSSEEGSVG CCCCCCCCCCCCCCC		19845377
206	Phosphorylation	VGLGELSSEEGSVGS CCCCCCCCCCCCCCC		19845377
210	Phosphorylation	ELSSEEGSVGSDRGS CCCCCCCCCCCCCCC		26471730
213	Phosphorylation	SEEGSVGSDRGSIVD CCCCCCCCCCCCCCC		26471730
217	Phosphorylation	SVGSDRGSIVDTEEE CCCCCCCCCCCCHHH		25849741
221	Phosphorylation	DRGSIVDTEEEKEEE CCCCCCCCHHHHCHH		25849741
230	Phosphorylation	EEKEEEESDEDFAHH HHHCHHHCCCCCCCC		28355574
238	Phosphorylation	DEDFAHHSDNEQNRH CCCCCCCCCCCCCCC		28355574
246	Phosphorylation	DNEQNRHTTQMSDEE CCCCCCCCCCCCCCC		30576142
247	Phosphorylation	NEQNRHTTQMSDEEE CCCCCCCCCCCCCCC		30576142
250	Phosphorylation	NRHTTQMSDEEEDDD CCCCCCCCCCCCCCC		23927012
265	Phosphorylation	GCDLFADSEKEEEDI CCCCCCCCCHHHHHH		23927012
279	Phosphorylation	IEDIEENTRPKRSRP HHHHHHHCCCCCCCC		23927012
284	Phosphorylation	ENTRPKRSRPTSFAD HHCCCCCCCCCCHHH		29255136
287	Phosphorylation	RPKRSRPTSFADELA CCCCCCCCCHHHHHH		26846344
288	Phosphorylation	PKRSRPTSFADELAA CCCCCCCCHHHHHHH		26846344
310	Phosphorylation	GRVDEEPTTLPSGEA CCCCCCCCCCCCCCC		29255136
311	Phosphorylation	RVDEEPTTLPSGEAK CCCCCCCCCCCCCCC		22199227
314	Phosphorylation	EEPTTLPSGEAKPRK CCCCCCCCCCCCCCC		29255136
318	Ubiquitination	TLPSGEAKPRKTLKE CCCCCCCCCCCCHHH		-
331	Phosphorylation	KEKKERRTPSDDEED HHHHHHCCCCCCCCC		29255136
333	Phosphorylation	KKERRTPSDDEEDNL HHHHCCCCCCCCCCC		19664994
347	Phosphorylation	LFAPPKLTDEDFSPF CCCCCCCCCCCCCCC		21712546
352	Phosphorylation	KLTDEDFSPFGSGGG CCCCCCCCCCCCCCC		25159151
356	Phosphorylation	EDFSPFGSGGGLFSG CCCCCCCCCCCCCCC		25159151
362	Phosphorylation	GSGGGLFSGGKGLFD CCCCCCCCCCCCCCC		25159151
375	Phosphorylation	FDDEDEESDLFTEAP CCCCCCCCCCCCCCC		25159151
379	Phosphorylation	DEESDLFTEAPQDRQ CCCCCCCCCCCCCHH		29083192
385	Methylation	FTEAPQDRQAGASVK CCCCCCCHHCCCCCC		-
390	Phosphorylation	QDRQAGASVKEESSS CCHHCCCCCCCCCCC		23401153
395	Phosphorylation	GASVKEESSSSKPGK CCCCCCCCCCCCCCC		23403867
396	Phosphorylation	ASVKEESSSSKPGKK CCCCCCCCCCCCCCC		23403867
397	Phosphorylation	SVKEESSSSKPGKKI CCCCCCCCCCCCCCC		23403867
398	Phosphorylation	VKEESSSSKPGKKIP CCCCCCCCCCCCCCC		23403867
402	Acetylation	SSSSKPGKKIPAGAV CCCCCCCCCCCCCCE		12438907
437	Phosphorylation	PQKPEQPTPRKSPYG CCCCCCCCCCCCCCC		25849741
441	Phosphorylation	EQPTPRKSPYGPPPT CCCCCCCCCCCCCCC		25159151
443	Phosphorylation	PTPRKSPYGPPPTGL CCCCCCCCCCCCCCC		21082442
448	Phosphorylation	SPYGPPPTGLFDDDD CCCCCCCCCCCCCCC		30576142
464	Phosphorylation	DDDDDFFSAPHSKPS CCCCCCCCCCCCCCC		23186163
468	Phosphorylation	DFFSAPHSKPSKTGK CCCCCCCCCCCCCCC		23186163
471	Phosphorylation	SAPHSKPSKTGKVQS CCCCCCCCCCCCCEE		23186163
473	Phosphorylation	PHSKPSKTGKVQSTA CCCCCCCCCCCEEHH		23312004
478	Phosphorylation	SKTGKVQSTADIFGD CCCCCCEEHHHHHCC		28355574
479	Phosphorylation	KTGKVQSTADIFGDE CCCCCEEHHHHHCCC		23927012
498	Phosphorylation	FKEKAVASPEATVSQ HHHHHCCCCCCCCCC		19664994
502	Phosphorylation	AVASPEATVSQTDEN HCCCCCCCCCCCHHH		16964243
504	Phosphorylation	ASPEATVSQTDENKA CCCCCCCCCCHHHHH		25159151
506	Phosphorylation	PEATVSQTDENKARA CCCCCCCCHHHHHHH		25159151
518	Phosphorylation	ARAEKKVTLSSSKNL HHHHHEEEECCCCCC		29514088
520	Phosphorylation	AEKKVTLSSSKNLKP HHHEEEECCCCCCCC		21815630
521	Phosphorylation	EKKVTLSSSKNLKPS HHEEEECCCCCCCCC		29514088
522	Phosphorylation	KKVTLSSSKNLKPSS HEEEECCCCCCCCCC		20068231
523	Acetylation	KVTLSSSKNLKPSSE EEEECCCCCCCCCCC		11688093
528	Phosphorylation	SSKNLKPSSETKTQK CCCCCCCCCCCCCCC		20068231
529	Phosphorylation	SKNLKPSSETKTQKG CCCCCCCCCCCCCCC		25159151
531	Phosphorylation	NLKPSSETKTQKGLF CCCCCCCCCCCCCCC		20068231
533	Phosphorylation	KPSSETKTQKGLFSD CCCCCCCCCCCCCCC		27251789
539	Phosphorylation	KTQKGLFSDEEDSED CCCCCCCCCCCCHHH		19664994
544	Phosphorylation	LFSDEEDSEDLFSSQ CCCCCCCHHHHCCCC		25463755
549	Phosphorylation	EDSEDLFSSQSASKL CCHHHHCCCCCHHHH		23927012
550	Phosphorylation	DSEDLFSSQSASKLK CHHHHCCCCCHHHHC		23927012
552	Phosphorylation	EDLFSSQSASKLKGA HHHCCCCCHHHHCCC		25159151
554	Phosphorylation	LFSSQSASKLKGASL HCCCCCHHHHCCCCC		23927012
560	Phosphorylation	ASKLKGASLLPGKLP HHHHCCCCCCCCCCC		28555341
571	Phosphorylation	GKLPTLVSLFDDEDE CCCCCEEECCCCCCC		27251275
590	Ubiquitination	FGGTAAKKQTLCLQA CCCHHHHHHHHHHHH		-
592	Phosphorylation	GTAAKKQTLCLQAQR CHHHHHHHHHHHHHH		28555341
614	Phosphorylation	ELSKKKASALLFSSD HHHHHHHHHHHCCCC		30266825
619	Phosphorylation	KASALLFSSDEEDQW HHHHHHCCCCCHHCC		22167270
620	Phosphorylation	ASALLFSSDEEDQWN HHHHHCCCCCHHCCC		22167270
631	Phosphorylation	DQWNIPASQTHLASD HCCCCCHHHHEECCC		30266825
633	Phosphorylation	WNIPASQTHLASDSR CCCCHHHHEECCCCC		30266825
637	Phosphorylation	ASQTHLASDSRSKGE HHHHEECCCCCCCCC		23927012
639	Phosphorylation	QTHLASDSRSKGEPR HHEECCCCCCCCCCC		23927012
648	Phosphorylation	SKGEPRDSGTLQSQE CCCCCCCCCCCCHHH		21815630
650	Phosphorylation	GEPRDSGTLQSQEAK CCCCCCCCCCHHHHH		21815630
653	Phosphorylation	RDSGTLQSQEAKAVK CCCCCCCHHHHHHHH		21815630
662	Phosphorylation	EAKAVKKTSLFEEDE HHHHHHHCCCCCCCC		23927012
663	Phosphorylation	AKAVKKTSLFEEDEE HHHHHHCCCCCCCCC		23927012
680	Phosphorylation	LFAIAKDSQKKTQRV CEEEEECCCCCCCEE		29496963
684	Phosphorylation	AKDSQKKTQRVSLLF EECCCCCCCEEEEEE		26074081
688	Phosphorylation	QKKTQRVSLLFEDDV CCCCCEEEEEEECCC		26657352
697	Phosphorylation	LFEDDVDSGGSLFGS EEECCCCCCCCCCCC		30278072
700	Phosphorylation	DDVDSGGSLFGSPPT CCCCCCCCCCCCCCC		30278072
704	Phosphorylation	SGGSLFGSPPTSVPP CCCCCCCCCCCCCCC		30278072
707	Phosphorylation	SLFGSPPTSVPPATK CCCCCCCCCCCCCCC		23403867
708	Phosphorylation	LFGSPPTSVPPATKK CCCCCCCCCCCCCCC		23403867
713	Phosphorylation	PTSVPPATKKKETVS CCCCCCCCCCCCCCC		22199227
718	Phosphorylation	PATKKKETVSEAPPL CCCCCCCCCCCCCCC		29255136
720	Phosphorylation	TKKKETVSEAPPLLF CCCCCCCCCCCCCCC		29255136
728	Phosphorylation	EAPPLLFSDEEEKEA CCCCCCCCCHHHHHH		19664994
741	Phosphorylation	EAQLGVKSVDKKVES HHHHCCCHHHHHHHH		21712546
748	Phosphorylation	SVDKKVESAKESLKF HHHHHHHHHHHHHHH		-
752	Phosphorylation	KVESAKESLKFGRTD HHHHHHHHHHHCCCC		-
754	Ubiquitination	ESAKESLKFGRTDVA HHHHHHHHHCCCCHH		-
758	Phosphorylation	ESLKFGRTDVAESEK HHHHHCCCCHHHHHH		-
763	Phosphorylation	GRTDVAESEKEGLLT CCCCHHHHHHCCCCC		25159151
765	Acetylation	TDVAESEKEGLLTRS CCHHHHHHCCCCCHH		25953088
765	Ubiquitination	TDVAESEKEGLLTRS CCHHHHHHCCCCCHH		-
770	Phosphorylation	SEKEGLLTRSAQETV HHHCCCCCHHHHHHH		29514088
772	Phosphorylation	KEGLLTRSAQETVKH HCCCCCHHHHHHHHC		25159151
776	Phosphorylation	LTRSAQETVKHSDLF CCHHHHHHHHCHHHC		28857561
784	Phosphorylation	VKHSDLFSSSSPWDK HHCHHHCCCCCCCCC		23927012
785	Phosphorylation	KHSDLFSSSSPWDKG HCHHHCCCCCCCCCC		25159151
786	Phosphorylation	HSDLFSSSSPWDKGT CHHHCCCCCCCCCCC		23927012
787	Phosphorylation	SDLFSSSSPWDKGTK HHHCCCCCCCCCCCC		23927012
793	Phosphorylation	SSPWDKGTKPRTKTV CCCCCCCCCCCCHHH		23927012
797	Phosphorylation	DKGTKPRTKTVLSLF CCCCCCCCHHHHHHC		24719451
798	Acetylation	KGTKPRTKTVLSLFD CCCCCCCHHHHHHCC		7229147
799	Phosphorylation	GTKPRTKTVLSLFDE CCCCCCHHHHHHCCH		30278072
802	Phosphorylation	PRTKTVLSLFDEEED CCCHHHHHHCCHHHH		19664994
836	Phosphorylation	DPDAHPKSTGVFQDE CCCCCCCCCCCCCCH		25159151
837	Phosphorylation	PDAHPKSTGVFQDEE CCCCCCCCCCCCCHH		25106551
848	Phosphorylation	QDEELLFSHKLQKDN CCHHHHHHHCCCCCC		28555341
850	Ubiquitination	EELLFSHKLQKDNDP HHHHHHHCCCCCCCC		-
869	Ubiquitination	FAGTKKTKLLEPSVG CCCCCCCCCCCCCHH		-
874	Phosphorylation	KTKLLEPSVGSLFGD CCCCCCCCHHHHHCC		23403867
877	Phosphorylation	LLEPSVGSLFGDDED CCCCCHHHHHCCCCC		25159151
889	Phosphorylation	DEDDDLFSSAKSQPL CCCCCHHHHHCCCCH		23403867
890	Phosphorylation	EDDDLFSSAKSQPLV CCCCHHHHHCCCCHH		26657352
893	Phosphorylation	DLFSSAKSQPLVQEK CHHHHHCCCCHHHHH		25159151
909	Phosphorylation	RVVKKDHSVDSFKNQ HHHCCCCCCHHHCCC		28355574
912	Phosphorylation	KKDHSVDSFKNQKHP CCCCCCHHHCCCCCC		25159151
917	Acetylation	VDSFKNQKHPESIQG CHHHCCCCCCHHHCC		25953088
925	Phosphorylation	HPESIQGSKEKGIWK CCHHHCCCCCCCCCC		25159151
935	Phosphorylation	KGIWKPETPQDSSGL CCCCCCCCCCCCCCC		25159151
939	Phosphorylation	KPETPQDSSGLAPFK CCCCCCCCCCCCCCC		25159151
940	Phosphorylation	PETPQDSSGLAPFKT CCCCCCCCCCCCCCC		29978859
971	Sulfoxidation	NPAALLPTAASQISE CHHHHHHHHHHHHHH		21406390
990	Phosphorylation	LPELAFPSSEHRRSH CHHHCCCCCHHHHHC		25627689
991	Phosphorylation	PELAFPSSEHRRSHG HHHCCCCCHHHHHCC		25159151
996	Phosphorylation	PSSEHRRSHGLESVP CCCHHHHHCCCCCCC		23401153
1001	Phosphorylation	RRSHGLESVPVLPGS HHHCCCCCCCCCCCC		23927012
1008	Phosphorylation	SVPVLPGSGEAGVSF CCCCCCCCCCCCCCC		28450419
1014	Phosphorylation	GSGEAGVSFDLPAQA CCCCCCCCCCCCCCC		27251275
1023	Phosphorylation	DLPAQADTLHSANKS CCCCCCCCHHHCCHH		27251275
1026	Phosphorylation	AQADTLHSANKSRVK CCCCCHHHCCHHHHH		20873877
1053	Phosphorylation	RRLAAQESSETEDMS HHHHHHHCCCCCCCC		23927012
1054	Phosphorylation	RLAAQESSETEDMSV HHHHHHCCCCCCCCC		25159151
1056	Phosphorylation	AAQESSETEDMSVPR HHHHCCCCCCCCCCC		23927012
1060	Phosphorylation	SSETEDMSVPRGPIA CCCCCCCCCCCCCHH		23403867
1075	Phosphorylation	QWADGAISPNGHRPQ HHCCCCCCCCCCCCH		25159151
1087	Phosphorylation	RPQLRAASGEDSTEE CCHHHHCCCCCCHHH		28176443
1091	Phosphorylation	RAASGEDSTEEALAA HHCCCCCCHHHHHHH		28176443
1092	Phosphorylation	AASGEDSTEEALAAA HCCCCCCHHHHHHHH		28176443
1114	Phosphorylation	PVPGVDRSPFAKSLG CCCCCCCCHHHHHHC		25159151
1119	Phosphorylation	DRSPFAKSLGHSRGE CCCHHHHHHCCCCCC		29496963
1123	Phosphorylation	FAKSLGHSRGEADLF HHHHHCCCCCCCCCC		25159151
1132	Phosphorylation	GEADLFDSGDIFSTG CCCCCCCCCCCCCCC		18669648
1137	Phosphorylation	FDSGDIFSTGTGSQS CCCCCCCCCCCCCCC		29396449
1138	Phosphorylation	DSGDIFSTGTGSQSV CCCCCCCCCCCCCCC		25850435
1140	Phosphorylation	GDIFSTGTGSQSVER CCCCCCCCCCCCCCC		30576142
1142	Phosphorylation	IFSTGTGSQSVERTK CCCCCCCCCCCCCCC		25159151
1144	Phosphorylation	STGTGSQSVERTKPK CCCCCCCCCCCCCCC		25159151
1169	Phosphorylation	PVGGKAKSPMFPALG CCCCCCCCCCCCCCC		29255136
1179	Phosphorylation	FPALGEASSDDDLFQ CCCCCCCCCCCHHHH		23927012
1180	Phosphorylation	PALGEASSDDDLFQS CCCCCCCCCCHHHHH		23927012
1187	Phosphorylation	SDDDLFQSAKPKPAK CCCHHHHHCCCCCCC		23927012
1195	Ubiquitination	AKPKPAKKTNPFPLL CCCCCCCCCCCCCCC		-
1196	Phosphorylation	KPKPAKKTNPFPLLE CCCCCCCCCCCCCCC		23879269
1221	Phosphorylation	VKKNETKSNSQQDVI CCCCCCCCCCCCCEE		28348404
1223	Phosphorylation	KNETKSNSQQDVILT CCCCCCCCCCCEEEE		28348404
1230	Phosphorylation	SQQDVILTTQDIFED CCCCEEEEEHHHHHC		28102081
1231	Phosphorylation	QQDVILTTQDIFEDD CCCEEEEEHHHHHCC		28102081
1260	Phosphorylation	EKEKTLESNLFDDNI HHHHHHHHHCCCCCC		28258704
1289	Phosphorylation	KKKVEAKSIFDDDMD CCHHHHHHHCCCCHH		27251275
1309	Acetylation	GIQAKTTKPKSRSAQ CCCCCCCCCCCCCCC		19826635
1311	Acetylation	QAKTTKPKSRSAQAA CCCCCCCCCCCCCCC		19826643
1312	Phosphorylation	AKTTKPKSRSAQAAP CCCCCCCCCCCCCCC		28102081
1314	Phosphorylation	TTKPKSRSAQAAPEP CCCCCCCCCCCCCCC		28102081
1328	Phosphorylation	PRFEHKVSNIFDDPL CCCCCCCCHHCCCCC		21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
700	S	Phosphorylation	Kinase	MTOR	P42345	PSP
704	S	Phosphorylation	Kinase	MTOR	P42345	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WAC2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WAC2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WASC4_HUMAN	KIAA1033	physical	22939629
WASC5_HUMAN	KIAA0196	physical	22939629
WASH1_HUMAN	WASH1	physical	22939629
ANFY1_HUMAN	ANKFY1	physical	22863883
PAAF1_HUMAN	PAAF1	physical	22863883
ROCK1_HUMAN	ROCK1	physical	22863883
ROCK2_HUMAN	ROCK2	physical	22863883

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.