WDR48_MOUSE - dbPTM
WDR48_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WDR48_MOUSE
UniProt AC Q8BH57
Protein Name WD repeat-containing protein 48
Gene Name Wdr48
Organism Mus musculus (Mouse).
Sequence Length 676
Subcellular Localization Nucleus . Cytoplasm . Lysosome . Late endosome . Mainly in cytoplasmic compartments.
Protein Description Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate..
Protein Sequence MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDVVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLHRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVTPMDEEENEVNHVSGGQESRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETEAMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYRQKST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28PhosphorylationIRDEVEKYNRNGVNA
EHHHHHHHCCCCCCH		13.0722817900
119PhosphorylationTLRTHKDYVKALAYA
HHHHCHHHHHHHHHH		14.5122817900
125PhosphorylationDYVKALAYAKDKELV
HHHHHHHHHCCHHHH		18.2922817900
214AcetylationKGHTDNVKALLLHRD
CCCCCCCEEEEEECC		39.30-
294UbiquitinationRVLICEEKAPVLKME
EEEEECCCCCEEEEE		35.3822790023
318UbiquitinationAIWVATTKSTVNKWT
EEEEEECCHHHCCEE		39.5122790023
327UbiquitinationTVNKWTLKGIHNFRA
HHCCEECCEEECCCC		48.7422790023
333UbiquitinationLKGIHNFRASGDYDN
CCEEECCCCCCCCCC		32.9127667366
335PhosphorylationGIHNFRASGDYDNDC
EEECCCCCCCCCCCC		28.1325521595
338PhosphorylationNFRASGDYDNDCTNP
CCCCCCCCCCCCCCC		21.8525521595
343PhosphorylationGDYDNDCTNPITPLC
CCCCCCCCCCCCCCC		47.0626745281
347PhosphorylationNDCTNPITPLCTQPD
CCCCCCCCCCCCCCC		16.0923984901
351PhosphorylationNPITPLCTQPDQVIK
CCCCCCCCCCCCEEE		51.3123984901
386PhosphorylationDTNNNVAYWDVLKAC
CCCCCEEHHHHHHHC		9.62-
400UbiquitinationCKVEDLGKVDFEDEI
CCCHHHCCCCCHHHH		46.0222790023
451PhosphorylationSAKDAGFSSPDGSDP
EHHHCCCCCCCCCCC		39.7929899451
452PhosphorylationAKDAGFSSPDGSDPK
HHHCCCCCCCCCCCC		25.4225521595
456PhosphorylationGFSSPDGSDPKLNLG
CCCCCCCCCCCCCHH		59.1120415495
480PhosphorylationYWPRTHVTPMDEEEN
HCCCCCCCCCCCCCC		12.80-
574PhosphorylationFYLQPHASSGAKTLK
EEECCCCCCCCCCCC		26.6929899451
575PhosphorylationYLQPHASSGAKTLKK
EECCCCCCCCCCCCC		43.4829899451
578AcetylationPHASSGAKTLKKDRL
CCCCCCCCCCCCCCC		58.8923806337
586PhosphorylationTLKKDRLSASDMLQV
CCCCCCCCHHHHHHH		26.9822817900
588PhosphorylationKKDRLSASDMLQVRK
CCCCCCHHHHHHHHH		21.8522807455
611PhosphorylationIINLDNESQTTSSSN
HHCCCCCCCCCCCCC		38.8025521595
613PhosphorylationNLDNESQTTSSSNNE
CCCCCCCCCCCCCCC		37.6129550500
614PhosphorylationLDNESQTTSSSNNEK
CCCCCCCCCCCCCCC		20.9729550500
615PhosphorylationDNESQTTSSSNNEKP
CCCCCCCCCCCCCCH		34.8529550500
616PhosphorylationNESQTTSSSNNEKPE
CCCCCCCCCCCCCHH		34.6929550500
621UbiquitinationTSSSNNEKPEQEKEE
CCCCCCCCHHHHHHH		56.8522790023
663PhosphorylationVKHFIWKSGGDLTLH
HEEEHHHCCCCEEEE		32.77-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WDR48_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WDR48_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WDR48_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TCPZ_HUMANCCT6Aphysical
26496610
DMWD_HUMANDMWDphysical
26496610
H33_HUMANH3F3Aphysical
26496610
NPTX1_HUMANNPTX1physical
26496610
TCPA_HUMANTCP1physical
26496610
TCPG_HUMANCCT3physical
26496610
UBP1_HUMANUSP1physical
26496610
CDK10_HUMANCDK10physical
26496610
GUAA_HUMANGMPSphysical
26496610
NOLC1_HUMANNOLC1physical
26496610
CE350_HUMANCEP350physical
26496610
TCPH_HUMANCCT7physical
26496610
TCPD_HUMANCCT4physical
26496610
TCPB_HUMANCCT2physical
26496610
TCPQ_HUMANCCT8physical
26496610
RASF8_HUMANRASSF8physical
26496610
TCPE_HUMANCCT5physical
26496610
ORC3_HUMANORC3physical
26496610
GPAM1_HUMANGPALPP1physical
26496610
BIRC6_HUMANBIRC6physical
26496610
ILKAP_HUMANILKAPphysical
26496610
WDR20_HUMANWDR20physical
26496610
ARID2_HUMANARID2physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WDR48_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-338, AND MASSSPECTROMETRY.
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-28, AND MASSSPECTROMETRY.

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