LRCH3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRCH3_MOUSE
• UniProt AC: Q8BVU0
• Protein Name: Leucine-rich repeat and calponin homology domain-containing protein 3
• Gene Name: Lrch3
• Organism: Mus musculus (Mouse).
• Sequence Length: 778
• Subcellular Localization: Secreted .
• Protein Sequence: MAAAGLVAVVAAAEYSGPVASGGNLSGATCGPSPGLGPGPGPGSWSRSVDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPMEACHFVSLESLNLYQNCIRYIPEAVLNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTVPSQIGNLEALRDFNVRRNHLLRLPEELAEVPLIRLDFSCNKITVIPVCYRNLRHLQVITLDNNPLQSPPAQICIKGKIHIFKYLNIQACKIAPDLPDYERRPLGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRSSVAVTNGGVEHDLDQIDYIDSCTTEEEENDVKQPKSLDTNSLSSQFMAYIEQRRISHEVSPVKPIAVREFQKTEDMKRYSHQNRVPVEPSLVLSMPPSHNQLSHSDLELHQRREQSIECTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASHNPQRQQPPGNGECSFPSRRSQHTDDSALLVSLSGLDGVSCVATRPHSSAFTPLKSENRVDVTSSFPMTETVHHSPAYSFPAATQRNQPQRPESFLFRAAVRAEANKGRASPLLLSSAPATDPTDAITRQREEELKLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIGVPQEQLCLPLHILEEKGLGQVAVTVQALLELAPPKQPPPQQPQQQQPQLSAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	ALEEAAVTGVLSLSG HHHHHHHHHHEECCC	19.49	21454597
63	Phosphorylation	AAVTGVLSLSGRKLR HHHHHHEECCCCCHH	20.34	21454597
65	Phosphorylation	VTGVLSLSGRKLREF HHHHEECCCCCHHCC	32.93	21454597
95	Phosphorylation	DLSRNRLSEIPMEAC HHHCCCHHCCCHHHH	30.18	24719451
301	Phosphorylation	GSCHEELYSGRPYGA CCCCHHHHCCCCCCC	16.62	22817900
324	Phosphorylation	DSGDKRWSGNEPTDE CCCCCCCCCCCCCCC	35.46	25521595
329	Phosphorylation	RWSGNEPTDEFSDLP CCCCCCCCCCCCCCC	41.82	25619855
333	Phosphorylation	NEPTDEFSDLPLRVA CCCCCCCCCCCHHHH	35.87	23984901
343	Phosphorylation	PLRVAEITKEQRLRR CHHHHHHCHHHHHHH	21.75	23984901
352	Phosphorylation	EQRLRRESQYQENRS HHHHHHHHHHHHHHH	32.17	25266776
354	Phosphorylation	RLRRESQYQENRSSV HHHHHHHHHHHHHCE	27.37	25367039
395	Phosphorylation	NDVKQPKSLDTNSLS CCCCCCCCCCCCCHH	37.85	26643407
398	Phosphorylation	KQPKSLDTNSLSSQF CCCCCCCCCCHHHHH	31.81	26643407
415	Phosphorylation	YIEQRRISHEVSPVK HHHHCCCCCCCCCCC	16.28	26824392
419	Phosphorylation	RRISHEVSPVKPIAV CCCCCCCCCCCCCEE	22.46	26824392
514	Phosphorylation	DFVKQKASHNPQRQQ HHHHHHHCCCCCCCC	30.72	22817900
583	Phosphorylation	VTSSFPMTETVHHSP CCCCCCCCCCCCCCC	28.83	26643407
585	Phosphorylation	SSFPMTETVHHSPAY CCCCCCCCCCCCCCC	18.90	26643407
589	Phosphorylation	MTETVHHSPAYSFPA CCCCCCCCCCCCCCC	9.06	26643407
592	Phosphorylation	TVHHSPAYSFPAATQ CCCCCCCCCCCCCCC	17.77	26643407
593	Phosphorylation	VHHSPAYSFPAATQR CCCCCCCCCCCCCCC	27.19	26643407
598	Phosphorylation	AYSFPAATQRNQPQR CCCCCCCCCCCCCCC	30.12	26643407
608	Phosphorylation	NQPQRPESFLFRAAV CCCCCCHHHHHHHHH	29.90	26824392
625	Phosphorylation	EANKGRASPLLLSSA HHHCCCCCCCHHCCC	18.08	25521595
630	Phosphorylation	RASPLLLSSAPATDP CCCCCHHCCCCCCCC	25.15	28833060
631	Phosphorylation	ASPLLLSSAPATDPT CCCCHHCCCCCCCCC	37.94	28833060
635	Phosphorylation	LLSSAPATDPTDAIT HHCCCCCCCCCCHHH	41.26	28833060
638	Phosphorylation	SAPATDPTDAITRQR CCCCCCCCCHHHHHH	40.65	28833060
642	Phosphorylation	TDPTDAITRQREEEL CCCCCHHHHHHHHHH	23.59	28833060
692	Phosphorylation	ANHVRPRSVPSIHVP CCCCCCCCCCCCCCC	40.85	26370283
700	Phosphorylation	VPSIHVPSPAVPKLT CCCCCCCCCCCCCHH	25.13	22942356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRCH3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRCH3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRCH3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LRCH3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.