dbPTM

EWS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EWS_MOUSE
UniProt AC	Q61545
Protein Name	RNA-binding protein EWS
Gene Name	Ewsr1
Organism	Mus musculus (Mouse).
Sequence Length	655
Subcellular Localization	Nucleus. Cytoplasm. Cell membrane. Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation..
Protein Description	Might function as a transcriptional repressor..
Protein Sequence	MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYSTPTAPQAYSQPVQGYGTGTYDSTTATVTTTQASYAAQTAYGTQPAYPTYGQQPTATAPTRPQDGNKPAETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYPMQPVTAPPSYPPTSYSSSQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQDHPSSMGVYGQESGGFSGPGENRSLSGPDNRGRGRGGFDRGGMSRGGRGGGRGGLGAGERGGFNKPGGPMDEGPDLDLGLPIDPDEDSDNSAIYVQGLNDNVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSMRGGMPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCPNPGCGNQNFAWRTECNQCKAPKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGPLMEQMGGRRGGRGGPGKMDKGEHRQERRDRPY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	QPPTGYSTPTAPQAY CCCCCCCCCCCCCCC	19.04	19076070
266	Phosphorylation	SSYGQQSSFRQDHPS CCCCCCCCCCCCCCC	21.80	-
295	Phosphorylation	PGENRSLSGPDNRGR CCCCCCCCCCCCCCC	49.91	22871156
300	Methylation	SLSGPDNRGRGRGGF CCCCCCCCCCCCCCC	43.49	-
300	Asymmetric dimethylarginine	SLSGPDNRGRGRGGF CCCCCCCCCCCCCCC	43.49	-
302	Methylation	SGPDNRGRGRGGFDR CCCCCCCCCCCCCCC	28.53	-
302	Asymmetric dimethylarginine	SGPDNRGRGRGGFDR CCCCCCCCCCCCCCC	28.53	-
304	Asymmetric dimethylarginine	PDNRGRGRGGFDRGG CCCCCCCCCCCCCCC	40.47	-
304	Methylation	PDNRGRGRGGFDRGG CCCCCCCCCCCCCCC	40.47	-
309	Asymmetric dimethylarginine	RGRGGFDRGGMSRGG CCCCCCCCCCCCCCC	41.10	-
309	Methylation	RGRGGFDRGGMSRGG CCCCCCCCCCCCCCC	41.10	-
314	Asymmetric dimethylarginine	FDRGGMSRGGRGGGR CCCCCCCCCCCCCCC	42.57	-
314	Methylation	FDRGGMSRGGRGGGR CCCCCCCCCCCCCCC	42.57	-
317	Methylation	GGMSRGGRGGGRGGL CCCCCCCCCCCCCCC	43.33	-
317	Asymmetric dimethylarginine	GGMSRGGRGGGRGGL CCCCCCCCCCCCCCC	43.33	-
321	Methylation	RGGRGGGRGGLGAGE CCCCCCCCCCCCCCC	39.00	-
321	Asymmetric dimethylarginine	RGGRGGGRGGLGAGE CCCCCCCCCCCCCCC	39.00	-
423	Ubiquitination	YEDPPTAKAAVEWFD CCCCCCCCEEEEEEC	39.08	-
432	Ubiquitination	AVEWFDGKDFQGSKL EEEEECCCCCCCCEE	58.16	-
438	Acetylation	GKDFQGSKLKVSLAR CCCCCCCEEEEECCC	60.18	23806337
442	Phosphorylation	QGSKLKVSLARKKPP CCCEEEEECCCCCCC	18.09	29176673
454	Methylation	KPPMNSMRGGMPPRE CCCCCCCCCCCCCCC	38.03	-
454	Asymmetric dimethylarginine	KPPMNSMRGGMPPRE CCCCCCCCCCCCCCC	38.03	-
463	Methylation	GMPPREGRGMPPPLR CCCCCCCCCCCCCCC	33.22	-
463	Asymmetric dimethylarginine	GMPPREGRGMPPPLR CCCCCCCCCCCCCCC	33.22	-
470	Methylation	RGMPPPLRGGPGGPG CCCCCCCCCCCCCCC	54.52	24129315
470	Asymmetric dimethylarginine	RGMPPPLRGGPGGPG CCCCCCCCCCCCCCC	54.52	-
485	Methylation	GPGGPMGRMGGRGGD CCCCCCCCCCCCCCC	17.83	24129315
489	Asymmetric dimethylarginine	PMGRMGGRGGDRGGF CCCCCCCCCCCCCCC	39.94	-
489	Methylation	PMGRMGGRGGDRGGF CCCCCCCCCCCCCCC	39.94	-
493	Asymmetric dimethylarginine	MGGRGGDRGGFPPRG CCCCCCCCCCCCCCC	50.86	-
493	Methylation	MGGRGGDRGGFPPRG CCCCCCCCCCCCCCC	50.86	-
499	Asymmetric dimethylarginine	DRGGFPPRGPRGSRG CCCCCCCCCCCCCCC	68.90	-
499	Methylation	DRGGFPPRGPRGSRG CCCCCCCCCCCCCCC	68.90	-
502	Methylation	GFPPRGPRGSRGNPS CCCCCCCCCCCCCCC	59.55	24129315
502	Asymmetric dimethylarginine	GFPPRGPRGSRGNPS CCCCCCCCCCCCCCC	59.55	-
505	Methylation	PRGPRGSRGNPSGGG CCCCCCCCCCCCCCC	52.29	24129315
505	Asymmetric dimethylarginine	PRGPRGSRGNPSGGG CCCCCCCCCCCCCCC	52.29	-
528	Glutathionylation	WQCPNPGCGNQNFAW CCCCCCCCCCCCCEE	4.95	24333276
562	Asymmetric dimethylarginine	FPPPGGDRGRGGPGG CCCCCCCCCCCCCCC	39.73	-
562	Methylation	FPPPGGDRGRGGPGG CCCCCCCCCCCCCCC	39.73	-
564	Asymmetric dimethylarginine	PPGGDRGRGGPGGMR CCCCCCCCCCCCCCC	48.03	-
564	Methylation	PPGGDRGRGGPGGMR CCCCCCCCCCCCCCC	48.03	-
571	Methylation	RGGPGGMRGGRGGLM CCCCCCCCCCCCCCC	47.92	-
571	Asymmetric dimethylarginine	RGGPGGMRGGRGGLM CCCCCCCCCCCCCCC	47.92	-
574	Asymmetric dimethylarginine	PGGMRGGRGGLMDRG CCCCCCCCCCCCCCC	38.54	-
574	Methylation	PGGMRGGRGGLMDRG CCCCCCCCCCCCCCC	38.54	-
580	Asymmetric dimethylarginine	GRGGLMDRGGPGGMF CCCCCCCCCCCCCCC	37.69	-
580	Methylation	GRGGLMDRGGPGGMF CCCCCCCCCCCCCCC	37.69	-
588	Asymmetric dimethylarginine	GGPGGMFRGGRGGDR CCCCCCCCCCCCCCC	37.45	-
588	Methylation	GGPGGMFRGGRGGDR CCCCCCCCCCCCCCC	37.45	-
591	Asymmetric dimethylarginine	GGMFRGGRGGDRGGF CCCCCCCCCCCCCCC	49.06	-
591	Methylation	GGMFRGGRGGDRGGF CCCCCCCCCCCCCCC	49.06	-
595	Methylation	RGGRGGDRGGFRGGR CCCCCCCCCCCCCCC	50.86	-
595	Asymmetric dimethylarginine	RGGRGGDRGGFRGGR CCCCCCCCCCCCCCC	50.86	-
599	Asymmetric dimethylarginine	GGDRGGFRGGRGMDR CCCCCCCCCCCCCCC	50.35	-
599	Methylation	GGDRGGFRGGRGMDR CCCCCCCCCCCCCCC	50.35	-
602	Methylation	RGGFRGGRGMDRGGF CCCCCCCCCCCCCCC	39.84	-
602	Asymmetric dimethylarginine	RGGFRGGRGMDRGGF CCCCCCCCCCCCCCC	39.84	-
606	Methylation	RGGRGMDRGGFGGGR CCCCCCCCCCCCCCC	37.94	-
606	Asymmetric dimethylarginine	RGGRGMDRGGFGGGR CCCCCCCCCCCCCCC	37.94	-
614	Methylation	GGFGGGRRGGPGGPP CCCCCCCCCCCCCCC	58.66	24129315
614	Asymmetric dimethylarginine	GGFGGGRRGGPGGPP CCCCCCCCCCCCCCC	58.66	-
632	Methylation	MEQMGGRRGGRGGPG HHHCCCCCCCCCCCC	56.01	-
632	Asymmetric dimethylarginine	MEQMGGRRGGRGGPG HHHCCCCCCCCCCCC	56.01	-
635	Asymmetric dimethylarginine	MGGRRGGRGGPGKMD CCCCCCCCCCCCCCC	50.12	-
635	Methylation	MGGRRGGRGGPGKMD CCCCCCCCCCCCCCC	50.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
266	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
266	S	Phosphorylation		-
Phosphorylated; calmodulin-binding inhibits phosphorylation of Ser-266.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EWS_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JARD2_MOUSE	Jarid2	physical	20211142
MECP2_MOUSE	Mecp2	physical	20211142
MTF2_MOUSE	Mtf2	physical	20211142
PER1_MOUSE	Per1	physical	20211142
REST_MOUSE	Rest	physical	20211142
RORG_MOUSE	Rorc	physical	20211142
RPA1_MOUSE	Polr1a	physical	20211142
KDM5D_MOUSE	Kdm5d	physical	20211142
SRBP1_MOUSE	Srebf1	physical	20211142
PHF1_MOUSE	Phf1	physical	20211142
DEDD_MOUSE	Dedd	physical	20211142
UBIP1_MOUSE	Ubp1	physical	20211142
ZFP42_MOUSE	Zfp42	physical	20211142
ZN292_MOUSE	Zfp292	physical	20211142
TRIP4_MOUSE	Trip4	physical	20211142
ANR49_MOUSE	Ankrd49	physical	20211142
MED20_MOUSE	Med20	physical	20211142
SIR2_MOUSE	Sirt2	physical	20211142
ZDHC6_MOUSE	Zdhhc6	physical	20211142
SYF1_MOUSE	Xab2	physical	20211142
ANRA2_MOUSE	Ankra2	physical	20211142
RPC6_MOUSE	Polr3f	physical	20211142
CERS5_MOUSE	Cers5	physical	20211142
ERCC8_MOUSE	Ercc8	physical	20211142
MMS19_MOUSE	Mms19	physical	20211142
NKD2_MOUSE	Nkd2	physical	20211142
ASB6_MOUSE	Asb6	physical	20211142
ANKR7_MOUSE	Ankrd7	physical	20211142
RAI14_MOUSE	Rai14	physical	20211142
CERS2_MOUSE	Cers2	physical	20211142
NKRF_MOUSE	Nkrf	physical	20211142
ABTB1_MOUSE	Abtb1	physical	20211142
SMCA1_MOUSE	Smarca1	physical	20211142
PWP1_MOUSE	Pwp1	physical	20211142
CHD4_MOUSE	Chd4	physical	20211142
TLE6_MOUSE	Tle6	physical	20211142
RFXAP_MOUSE	Rfxap	physical	20211142
HDA10_MOUSE	Hdac10	physical	20211142
ASH1L_MOUSE	Ash1l	physical	20211142
ZSWM4_MOUSE	Zswim4	physical	20211142
MED16_MOUSE	Med16	physical	20211142
SNPC4_MOUSE	Snapc4	physical	20211142
RPB2_MOUSE	Polr2b	physical	20211142
ZBT24_MOUSE	Zbtb24	physical	20211142
ZFP82_MOUSE	Zfp82	physical	20211142
K2C5_HUMAN	KRT5	physical	26496610
MED24_HUMAN	MED24	physical	26496610
ATG2A_HUMAN	ATG2A	physical	26496610
KLH12_HUMAN	KLHL12	physical	26496610
NUD18_HUMAN	NUDT18	physical	26496610
PRGC1_MOUSE	Ppargc1a	physical	25918410

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EWS_MOUSE

Related Literatures of Post-Translational Modification

show