dbPTM

ABTB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ABTB1_MOUSE
UniProt AC	Q99LJ2
Protein Name	Ankyrin repeat and BTB/POZ domain-containing protein 1
Gene Name	Abtb1 {ECO:0000312\|MGI:MGI:1933148}
Organism	Mus musculus (Mouse).
Sequence Length	478
Subcellular Localization	Cytoplasm .
Protein Description	May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity)..
Protein Sequence	MDTSDLFASCRKGDVGRVRYLLEQRDVEVNVRDKWDSTPLYYACLCGHEELVRYLLANGARCEANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLDDLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLRADMALLADCALPSELRGDLGELPFPCPDGFSSCPDICFRVADSSFLCHKAFFCGRSDYFRALLDDHFQESEEPAASGDPPVVTLHDISPDIFIHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLEEDSVVGVWRIAKMFRLARLEDQCTEYMAKVIEKLVEREDFVEAVREEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	Phosphorylation	ASCRRRDYYDDFLQR HHHHCCCCHHHHHHH	13.64	142253
101	Phosphorylation	SCRRRDYYDDFLQRL HHHCCCCHHHHHHHH	17.21	142257
152	Phosphorylation	DTKWKGKSVVVLRHP CCCCCCCEEEEECCC	28.90	81116143
193	Ubiquitination	SDCERLAKQCQLWDL HHHHHHHHHHCHHHH	57.08	-
218	Ubiquitination	VSEFVASKPGTCVKV HHHHHHCCCCCEEEE	37.42	22790023
406	Ubiquitination	QCTEYMAKVIEKLVE HHHHHHHHHHHHHHH	27.50	22790023
410	Ubiquitination	YMAKVIEKLVEREDF HHHHHHHHHHHCHHH	46.86	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ABTB1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ABTB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ABTB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ABTB1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ABTB1_MOUSE

Related Literatures of Post-Translational Modification