| UniProt ID | ZFP42_MOUSE | |
|---|---|---|
| UniProt AC | P22227 | |
| Protein Name | Zinc finger protein 42 | |
| Gene Name | Zfp42 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 288 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal.. | |
| Protein Sequence | MNEQKMNEQMKKTAKTSGQKGPGGRALDRLTLKQDEARPVQNTRVEAPRVTYTIRDESEISPETEEDGFPDGYLECIIRGEFSEPILEEDFLFKSFESLEEVEQNLSRQVLEASSLLESSLEYMTKGTKQEKTEVTQETPPLRVGASSLLAGGPAEKPEGGVYCGVLSMLECPQAGCKKKLRGKTALRKHMLVHGPRRHVCAECGKAFTESSKLKRHFLVHTGEKPYQCTFEGCGKRFSLDFNLRTHIRIHTGERRFVCPFDGCEKSFIQSNNQKIHILTHAKAGKKC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 33 | Ubiquitination | ALDRLTLKQDEARPV HHCCEEECCCCCCCC | 50.93 | - | |
| 83 | Phosphorylation | CIIRGEFSEPILEED EEEECCCCCCHHCCC | 37.85 | 21149613 | |
| 94 | Ubiquitination | LEEDFLFKSFESLEE HCCCHHHHCHHCHHH | 57.28 | - | |
| 98 | Phosphorylation | FLFKSFESLEEVEQN HHHHCHHCHHHHHHH | 38.79 | 22006019 | |
| 126 | Ubiquitination | SSLEYMTKGTKQEKT HHHHHHHCCCHHHCC | 48.31 | - | |
| 129 | Ubiquitination | EYMTKGTKQEKTEVT HHHHCCCHHHCCCCC | 66.19 | - | |
| 132 | Ubiquitination | TKGTKQEKTEVTQET HCCCHHHCCCCCCCC | 47.71 | - | |
| 213 | Ubiquitination | KAFTESSKLKRHFLV CCHHHCHHHEEEEEE | 68.27 | 22596162 | |
| 215 | Ubiquitination | FTESSKLKRHFLVHT HHHCHHHEEEEEEEC | 47.79 | 22596162 | |
| 222 | Phosphorylation | KRHFLVHTGEKPYQC EEEEEEECCCCCEEE | 39.29 | 23140645 | |
| 225 | Ubiquitination | FLVHTGEKPYQCTFE EEEECCCCCEEEEEC | 50.82 | - | |
| 239 | Phosphorylation | EGCGKRFSLDFNLRT CCCCCEEEEEEEECE | 30.94 | 28833060 | |
| 266 | Ubiquitination | CPFDGCEKSFIQSNN CCCCCCCEEEEECCC | 55.53 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZFP42_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZFP42_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZFP42_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PO5F1_MOUSE | Pou5f1 | physical | 17093407 | |
| TYY1_MOUSE | Yy1 | physical | 17093407 | |
| NACC1_MOUSE | Nacc1 | physical | 17093407 | |
| SMRCD_MOUSE | Smarcad1 | physical | 17093407 | |
| RAI14_MOUSE | Rai14 | physical | 17093407 | |
| ANM1_MOUSE | Prmt1 | physical | 17093407 | |
| RING2_MOUSE | Rnf2 | physical | 17093407 | |
| WAPL_MOUSE | Wapal | physical | 17093407 | |
| WDR18_MOUSE | Wdr18 | physical | 17093407 | |
| SMRC1_MOUSE | Smarcc1 | physical | 17093407 | |
| REQU_MOUSE | Dpf2 | physical | 17093407 | |
| TIF1B_MOUSE | Trim28 | physical | 17093407 | |
| RNF12_MOUSE | Rlim | physical | 22596162 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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