dbPTM

REQU_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	REQU_MOUSE
UniProt AC	Q61103
Protein Name	Zinc finger protein ubi-d4
Gene Name	Dpf2
Organism	Mus musculus (Mouse).
Sequence Length	391
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells..
Protein Sequence	MAAVVENVVKLLGEQYYKDAMEQCHNYNARLCAERSVRLPFLDSQTGVAQSNCYIWMEKRHRGPGLASGQLYSYPARRWRKKRRAHPPEDPRLSFPSIKPDTDQTLKKEGLISQDGSSLEALLRTDPLEKRGAPDPRVDDDSLGEFPVSNSRARKRIIEPDDFLDDLDDEDYEEDTPKRRGKGKSKSKGVSSARKKLDASILEDRDKPYACDICGKRYKNRPGLSYHYAHSHLAEEEGEDKEDSRPPTPVSQRSEEQKSKKGPDGLALPNNYCDFCLGDSKINKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRWQCIECKCCNLCGTSENDDQLLFCDDCDRGYHMYCLTPSMSEPPEGSWSCHLCLDLLKEKASIYQNQNSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAVVENVV ------CHHHHHHHH	14.68	-
108	Ubiquitination	DTDQTLKKEGLISQD CCCCHHHHCCCCCCC	61.19	-
113	Phosphorylation	LKKEGLISQDGSSLE HHHCCCCCCCCCHHH	27.54	22006019
117	Phosphorylation	GLISQDGSSLEALLR CCCCCCCCHHHHHHC	39.79	26745281
118	Phosphorylation	LISQDGSSLEALLRT CCCCCCCHHHHHHCC	35.44	26745281
125	Phosphorylation	SLEALLRTDPLEKRG HHHHHHCCCHHHHCC	41.77	30387612
142	Phosphorylation	DPRVDDDSLGEFPVS CCCCCCCCCCCCCCC	45.31	27087446
149	Phosphorylation	SLGEFPVSNSRARKR CCCCCCCCCHHHHCC	29.35	26643407
151	Phosphorylation	GEFPVSNSRARKRII CCCCCCCHHHHCCCC	21.58	26643407
155	Acetylation	VSNSRARKRIIEPDD CCCHHHHCCCCCCCC	47.14	23236377
172	Phosphorylation	DDLDDEDYEEDTPKR HCCCCCCCCCCCCCC	21.12	25619855
176	Phosphorylation	DEDYEEDTPKRRGKG CCCCCCCCCCCCCCC	33.71	22942356
200	Phosphorylation	ARKKLDASILEDRDK HHHHHCHHHHCCCCC	27.63	27600695
225	Phosphorylation	YKNRPGLSYHYAHSH CCCCCCCCHHHHHHH	18.77	25777480
226	Phosphorylation	KNRPGLSYHYAHSHL CCCCCCCHHHHHHHH	12.14	25777480
228	Phosphorylation	RPGLSYHYAHSHLAE CCCCCHHHHHHHHHH	9.58	25777480
231	Phosphorylation	LSYHYAHSHLAEEEG CCHHHHHHHHHHHHC	16.42	27717184
244	Phosphorylation	EGEDKEDSRPPTPVS HCCCCCCCCCCCCHH	48.02	23684622
248	Phosphorylation	KEDSRPPTPVSQRSE CCCCCCCCCHHHCCH	38.72	25521595
251	Phosphorylation	SRPPTPVSQRSEEQK CCCCCCHHHCCHHHH	22.53	23737553
254	Phosphorylation	PTPVSQRSEEQKSKK CCCHHHCCHHHHHCC	37.54	23375375
280	Phosphorylation	CDFCLGDSKINKKTG CCCCCCCCHHCCCCC	33.37	25266776
385	Phosphorylation	LKEKASIYQNQNSS- HHHHHHHHHCCCCC-	10.02	23984901
390	Phosphorylation	SIYQNQNSS------ HHHHCCCCC------	27.88	28285833
391	Phosphorylation	IYQNQNSS------- HHHCCCCC-------	52.36	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of REQU_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of REQU_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of REQU_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of REQU_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of REQU_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142, AND MASSSPECTROMETRY.	17203969 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-176, AND MASSSPECTROMETRY.	17242355 [Abstract]