TYY1_MOUSE - dbPTM
TYY1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TYY1_MOUSE
UniProt AC Q00899
Protein Name Transcriptional repressor protein YY1
Gene Name Yy1
Organism Mus musculus (Mouse).
Sequence Length 414
Subcellular Localization Nucleus . Nucleus matrix . Cytoplasm . Associated with the nuclear matrix. In testis, localized to heterochromatin of spermatocytes.
Protein Description Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. Binds to the upstream conserved region (UCR) (5'-CGCCATTTT-3') of Moloney murine leukemia virus (MuLV). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. [PubMed: 15329343 Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions]
Protein Sequence MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEEEDDDDEDGGGGDHGGGGGGHGHAGHHHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDGLRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGASSGGGRVKKGGGKKSGKKSYLGGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
30PhosphorylationLHEIEVETIPVETIE
EEEEEEEEEECEEEE
35.4422482732
120PhosphorylationEVVGGDDSDGLRAED
EECCCCCCCCCCCCC
38.0125521595
183UbiquitinationGGKKSGKKSYLGGGA
CCCCCCCCCCCCCCC
48.1022790023
184PhosphorylationGKKSGKKSYLGGGAG
CCCCCCCCCCCCCCC
29.1326643407
185PhosphorylationKKSGKKSYLGGGAGA
CCCCCCCCCCCCCCC
20.4618846507
203UbiquitinationGGADPGNKKWEQKQV
CCCCCCCCCCEECEE
66.2427667366
247PhosphorylationEQIIGENSPPDYSEY
EHHCCCCCCCCHHHH
33.2427087446
251PhosphorylationGENSPPDYSEYMTGK
CCCCCCCHHHHHCCC
14.8025619855
252PhosphorylationENSPPDYSEYMTGKK
CCCCCCHHHHHCCCC
29.6325619855
254PhosphorylationSPPDYSEYMTGKKLP
CCCCHHHHHCCCCCC
8.2725619855
256PhosphorylationPDYSEYMTGKKLPPG
CCHHHHHCCCCCCCC
44.9725619855
311PhosphorylationTKMFRDNSAMRKHLH
HHHHCCCHHHHHHHH
27.9429176673
348PhosphorylationKRHQLVHTGEKPFQC
CCCCCCCCCCCCEEE
39.2923140645
365PhosphorylationEGCGKRFSLDFNLRT
CCCCCEEEEEEECCE
30.9428833060
378PhosphorylationRTHVRIHTGDRPYVC
CEEEEEECCCCCEEC
38.1025266776
397PhosphorylationCNKKFAQSTNLKSHI
CCHHHHHHHCCHHHH
18.8122817900
398PhosphorylationNKKFAQSTNLKSHIL
CHHHHHHHCCHHHHH
32.2721183079
402PhosphorylationAQSTNLKSHILTHAK
HHHHCCHHHHHHHHH
20.9421183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TYY1_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TYY1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TYY1_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EP300_MOUSEEp300physical
17220375
CTCF_MOUSECtcfphysical
17218270
SP3_MOUSESp3physical
21149256
SMCA4_MOUSESmarca4physical
21149256
GON4L_MOUSEGon4lphysical
21454521
HDAC1_MOUSEHdac1physical
8917507
MTOR_MOUSEMtorphysical
18046414
PRGC1_MOUSEPpargc1aphysical
18046414

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TYY1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, AND MASSSPECTROMETRY.

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