GON4L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GON4L_MOUSE
• UniProt AC: Q9DB00
• Protein Name: GON-4-like protein
• Gene Name: Gon4l
• Organism: Mus musculus (Mouse).
• Sequence Length: 2260
• Subcellular Localization: Nucleus .
• Protein Description: Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. [PubMed: 21454521 Required for B cell lymphopoiesis]
• Protein Sequence: MLPCKKRRLSVTESSQQQDDQEGDDLDLEAAVKPDTDQLPDSASESLSWGQSQDSAVCPEGLSMQDGDDQLRAEGLSLNSKMLAQHVNLAVLEAVDVAVSQEIPLPSLESSHSLPVHVDKGRLQVSASKKGKRVVFTPGQVTREDRGDHPVPEEPPSGEPAEEAKTEGGELELRSDGEVPLLSSSSQSAKPGAQPRKSVQPDGSAFPQDKPLGPLVRQAEEEMEDGGLFIPTEEQDSEESDKKKKTKKGTKRKRDGKGPEQGTMVYDPKLDDMLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPLFEPKMTRSKLKEVVEKGVVIPTWNISPIKKASEIKQPPQFVDIHLEEDDSSDEEYSPDEEEEDETAEESLLESDVESTASSPRGVKRSRLRLSSEVAETDEESGMLSEVEKAATPALRHISAEVVPMGPPPPPKPKQSRDSVFMEKLDAVDEELASSPVCMDSFQPMEDSLIAFRTRSKMPLKDVPLGQLEAELQAPDITPDMYDPNTADDEDWKQWLGGLINDDVENEDEADDDDDPEYNFLEDLDEPDTEDFRTDRAVRITKKEVNGLMEELFETVQSVVPSKFQDEMGFSNMEDDGPEEEERATESRPSFNTPQALRFEEPLANLLNERHRTVKELLEQLKMKKPSVRQQPEVEKLKPQEEAAHQTLVLDPAQRSRLQQQMQQHVQLLTQIYLLTTSNPNLSSEASTTRIFLKELGTFAENSIALHQQFNPRFQTLFQPCNWMGAMRLIEDFTQVSIDCSPHKTAKKTASEFPCLPKQVAWILATNKVFMYPELLPICSLKANNPRDKTIFTKAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQLTVRIKNLNLNRAPNNVIKFYKKTKQLPVLVRCCEEIQPHQWKPPFEKEEHRLPFWLKASLQSIQDELRNISEGATEGGSVTTATESSTDQHLQKASPALGDEPQYPLLLPKGVVLKLKPGSKRFSRKAWRQKRPLVQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPSVGVRGEDGFESPTALPAMPCGSEARTTFPLSETQSAPPSCSAPKLMLPSLAPSKFRKPYVRRKPTRRKGAKVSPCVKPAPIIHPTPVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQTIPITTLLVNPTTFPCSLNQPLVASSISPLIVSSNPLTLPVTSIPEDKAQVKLDVAEGKNAPQNPESKLKPQELTPLCTTVFSKEEPKSWHSSADTGSQEAFSESSACSWAVVKTESQEGSSEKSACGWTVVKTEDGGHAVEPLPQNLQDSLSSSSKDLLNMVKMEAQDCMVEISSNFPKQDIGEEVKEECSMELDSESPQEKPSSASEMSKQTVLQREDMQAAKSPSVPQDAAAEGRTSSHASRGLPKSTLSSMGQGGGLSGPPGKLEDSANADGQSVGTPAGPDTGGEKDGPEEEEEEDFDDLTQDEEDELSSASEESVLSVPELQETMEKLTWLASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMETLQKEDEVNDEAVGDAAKKPPSTLASPQTAPEIETSIAPAGESIKAAGKGRSSHRARNKRGSRARASKDTSKLLLLYDEDILDRDPLREQKDLAFAQAYLTRVREALQHTPGKYEDFLQIIYEFESSTQMHSAVDLFKSLQTLLQDWPQLLKDFAAFLLPEQALSCGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKIIKVLQGCADCLPQDIAELKTQMWQLLRGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTEEKEYEFDGFEEVILPDVEEDEEPAKVSTASKSKRRKEIGVQHQDKDTEWPEAAKDCSCSCHEGGPESKLKKSKRRNCHCSSKVCDSKPYKSKEPPELVGSGPLHEASTVPGSKEAGQGKDMLEEEILEEQENMEVTQSKTARTTRKGEAPAPGSTIGSTLLCPAEVTPMELLLEGPALCSAETPRLPPQTGAVVCSVRRNQAGPEVVSCLSTSSLPPEEGEDQRAAANSETIAPHREASETERLPETVEHSAPLPSPVSTRTRDTGRRHICGKAGSQSWLIESRAEAEAAHVAAPICEKSSGARASEAAPKTAREVLAEDSGTQGMGPEGALPKASEATVCANNSKVSSTGEKVVLWTREADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSHRFRELMQLFHTACEASSEDEDDATSTSNADQLSDHGDLLSEEELDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
343	Phosphorylation	EKGVVIPTWNISPIK HCCCEECCCCCCCCC	21.73	25159016
347	Phosphorylation	VIPTWNISPIKKASE EECCCCCCCCCCHHH	19.84	22942356
414	Phosphorylation	KRSRLRLSSEVAETD CHHHHCCCCCHHHCC	20.30	25266776
415	Phosphorylation	RSRLRLSSEVAETDE HHHHCCCCCHHHCCC	40.45	25266776
420	Phosphorylation	LSSEVAETDEESGML CCCCHHHCCCCCCCC	38.69	28066266
424	Phosphorylation	VAETDEESGMLSEVE HHHCCCCCCCCHHHH	27.70	30635358
428	Phosphorylation	DEESGMLSEVEKAAT CCCCCCCHHHHHHHC	30.61	-
477	Phosphorylation	AVDEELASSPVCMDS HHCHHHHCCCCCHHC	48.04	22006019
478	Phosphorylation	VDEELASSPVCMDSF HCHHHHCCCCCHHCC	18.75	22006019
525	Phosphorylation	PDITPDMYDPNTADD CCCCCCCCCCCCCCC	35.31	21149613
529	Phosphorylation	PDMYDPNTADDEDWK CCCCCCCCCCCHHHH	36.53	21149613
628	Phosphorylation	PEEEERATESRPSFN HHHHHHHHCCCCCCC	40.49	25367039
630	Phosphorylation	EEERATESRPSFNTP HHHHHHCCCCCCCCH	45.17	25367039
633	Phosphorylation	RATESRPSFNTPQAL HHHCCCCCCCCHHHH	29.98	25367039
636	Phosphorylation	ESRPSFNTPQALRFE CCCCCCCCHHHHCCH	18.11	25367039
777	Phosphorylation	MRLIEDFTQVSIDCS HHHHHCHHHEECCCC	40.14	26643407
780	Phosphorylation	IEDFTQVSIDCSPHK HHCHHHEECCCCCCC	11.68	26745281
784	Phosphorylation	TQVSIDCSPHKTAKK HHEECCCCCCCCCCC	26.70	25266776
792	Phosphorylation	PHKTAKKTASEFPCL CCCCCCCCHHHCCCC	34.41	22817900
869	Phosphorylation	KYLVTCKTAHQLTVR HHHHEECCHHHEEEE	31.36	22871156
874	Phosphorylation	CKTAHQLTVRIKNLN ECCHHHEEEEEECCC	10.94	-
969	Phosphorylation	DQHLQKASPALGDEP HHHHHHHCCCCCCCC	20.10	28066266
1077	Phosphorylation	RGEDGFESPTALPAM CCCCCCCCCCCCCCC	25.86	30635358
1079	Phosphorylation	EDGFESPTALPAMPC CCCCCCCCCCCCCCC	50.54	30635358
1337	Phosphorylation	LPQNLQDSLSSSSKD CCCCHHHHHCCCCHH	19.72	28285833
1378	Phosphorylation	EEVKEECSMELDSES HHHHHHHCCCCCCCC	20.69	22871156
1385	Phosphorylation	SMELDSESPQEKPSS CCCCCCCCCCCCCCC	35.52	22871156
1400	Phosphorylation	ASEMSKQTVLQREDM HHHHHHHHHHHHHHH	27.24	26643407
1412	Phosphorylation	EDMQAAKSPSVPQDA HHHHHHHCCCCCHHH	20.06	27149854
1414	Phosphorylation	MQAAKSPSVPQDAAA HHHHHCCCCCHHHHH	54.22	26643407
1464	Phosphorylation	SANADGQSVGTPAGP CCCCCCCCCCCCCCC	28.22	26643407
1467	Phosphorylation	ADGQSVGTPAGPDTG CCCCCCCCCCCCCCC	14.07	26643407
1581	Phosphorylation	DAAKKPPSTLASPQT HHHHCCCCCCCCCCC	44.58	26643407
1582	Phosphorylation	AAKKPPSTLASPQTA HHHCCCCCCCCCCCC	31.92	26643407
1585	Phosphorylation	KPPSTLASPQTAPEI CCCCCCCCCCCCCCC	22.21	25266776
1588	Phosphorylation	STLASPQTAPEIETS CCCCCCCCCCCCCCC	47.79	26643407
1822	Phosphorylation	NWTEEKEYEFDGFEE CCCCCEEEECCCCCE	32.72	25367039
1845	Phosphorylation	DEEPAKVSTASKSKR CCCCCCCCCCCHHHH	19.97	25367039
1846	Phosphorylation	EEPAKVSTASKSKRR CCCCCCCCCCHHHHH	37.63	25367039
1848	Phosphorylation	PAKVSTASKSKRRKE CCCCCCCCHHHHHHH	37.23	25367039
1925	Phosphorylation	SGPLHEASTVPGSKE CCCCCCCCCCCCCCC	27.27	-
1998	Phosphorylation	LEGPALCSAETPRLP HCCCEECCCCCCCCC	29.95	-
2074	Phosphorylation	EHSAPLPSPVSTRTR CCCCCCCCCCCCCCC	45.69	25159016
2077	Phosphorylation	APLPSPVSTRTRDTG CCCCCCCCCCCCCCC	18.63	26643407
2078	Phosphorylation	PLPSPVSTRTRDTGR CCCCCCCCCCCCCCC	35.97	26643407
2094	Phosphorylation	HICGKAGSQSWLIES EECCCCCCCEEEECH	26.38	27600695
2176	Phosphorylation	GEKVVLWTREADRVI CCEEEEEECCCCCEE	17.92	27149854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GON4L_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GON4L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GON4L_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3A_MOUSE	Sin3a	physical	21454521
HDAC1_MOUSE	Hdac1	physical	21454521
TYY1_MOUSE	Yy1	physical	21454521

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.