WDR18_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR18_MOUSE
• UniProt AC: Q4VBE8
• Protein Name: WD repeat-containing protein 18
• Gene Name: Wdr18
• Organism: Mus musculus (Mouse).
• Sequence Length: 431
• Subcellular Localization: Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm . Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.
• Protein Description: May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. [PubMed: 22872859 Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity]
• Protein Sequence: MAAPMEVVVCTDAAAQLWSCVVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQQGKNYICAWELQRKDQLQQKIMCPGPVTCLTTAPNGLYVLAGIAESIYLWEVCTGNLLVILSRHYQDVSCLKFTGDGSHFVSAGKDCLALAWSLCSVLQADPSRILAPRHVWSQHTLPITDLHCGFGGPMARVATASLDQTVKLWAISSGDLLLSVLFDMGITSVTMDLAEHHIFCGGSDGSIFQVDLCSWPGLREHSFQPEQNTGKVFKGHRNQVTCLSVSTDGSVLLSGSHDESVRLWDVKSKQCLRTVTLKGPVTNAAIILAPPSMLNPEFRPSLPLPHFNKHLLGAEHGDEAQGGGLRLQLGLHLQGKEPSYLERLEQLQAVLSSYLEKNMLGSQMLPARVFDLEDEVRSLRKINRDLFDFSTRIITRPSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	AAQQGKNYICAWELQ EEECCCCEEEEEECC	10.81	22817900
191	Phosphorylation	GPMARVATASLDQTV CCHHHHHCCCCCHHH	17.58	29472430
193	Phosphorylation	MARVATASLDQTVKL HHHHHCCCCCHHHHE	28.29	29472430
197	Phosphorylation	ATASLDQTVKLWAIS HCCCCCHHHHEEEEE	21.19	29472430
199	Acetylation	ASLDQTVKLWAISSG CCCCHHHHEEEEECC	41.52	7711807
368	Ubiquitination	LGLHLQGKEPSYLER EEEEECCCCCHHHHH	54.19	-
389	Ubiquitination	VLSSYLEKNMLGSQM HHHHHHHHCCCCCCC	45.09	-
410	Phosphorylation	DLEDEVRSLRKINRD CHHHHHHHHHHHCHH	37.39	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR18_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR18_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR18_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of WDR18_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.