UniProt ID | NACC1_MOUSE | |
---|---|---|
UniProt AC | Q7TSZ8 | |
Protein Name | Nucleus accumbens-associated protein 1 | |
Gene Name | Nacc1 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 514 | |
Subcellular Localization | Nucleus. Cytoplasm. Distribution in the cytoplasm is dependent on phosphorylation.. | |
Protein Description | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Involved in the acute behavioral and neurological responses to cocaine and amphetamines.. | |
Protein Sequence | MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTFCYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFFLKVSSPSCDSQGLHPEEAPSSEPQSPVAQTLGWPACSTPLPLVSRVKTEQELDSVQCTPMAKRLWDSSQKEAGGSGGNNGSRKMAKFSTPDLALNRMPQPLSMATATAAVAVVAVGGCVSGPSMSERTSPGTSSAYTSDSPSSYHNEEDEEEDAGEEGTDEQYRQICNMYTMYSMLNVGQTAEKVEALPEQVVLESRSRIRVRQDLASLPAELINQIGNRCHPKLYDEGDPSEKLELVTGTNVYITRAQLMNCHVSAGTRHKVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMNAIAADMCTNARRVVRKSWLPKTKPLHLVEGDNYSSFISDTCKIEPDMMSMEHSFETASHDGEAGPSAEVLQ | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
124 | Phosphorylation | TEFFLKVSSPSCDSQ CCEEEEECCCCCCCC | 34.64 | 25293948 | |
125 | Phosphorylation | EFFLKVSSPSCDSQG CEEEEECCCCCCCCC | 24.66 | 25293948 | |
127 | Phosphorylation | FLKVSSPSCDSQGLH EEEECCCCCCCCCCC | 32.29 | 25293948 | |
130 | Phosphorylation | VSSPSCDSQGLHPEE ECCCCCCCCCCCCCC | 30.40 | 25159016 | |
140 | Phosphorylation | LHPEEAPSSEPQSPV CCCCCCCCCCCCCCC | 55.15 | 25293948 | |
141 | Phosphorylation | HPEEAPSSEPQSPVA CCCCCCCCCCCCCCH | 52.84 | 25159016 | |
145 | Phosphorylation | APSSEPQSPVAQTLG CCCCCCCCCCHHHHC | 31.86 | 25159016 | |
150 | Phosphorylation | PQSPVAQTLGWPACS CCCCCHHHHCCCCCC | 19.94 | 25159016 | |
157 | Phosphorylation | TLGWPACSTPLPLVS HHCCCCCCCCCCCCC | 34.86 | 25159016 | |
158 | Phosphorylation | LGWPACSTPLPLVSR HCCCCCCCCCCCCCC | 28.82 | 25159016 | |
174 | Phosphorylation | KTEQELDSVQCTPMA CCHHHHCCCCCCHHH | 27.06 | 24759943 | |
178 | Phosphorylation | ELDSVQCTPMAKRLW HHCCCCCCHHHHHHH | 10.06 | 24759943 | |
187 | Phosphorylation | MAKRLWDSSQKEAGG HHHHHHHCCCHHHCC | 24.08 | 29514104 | |
188 | Phosphorylation | AKRLWDSSQKEAGGS HHHHHHCCCHHHCCC | 42.68 | 26745281 | |
208 | Phosphorylation | SRKMAKFSTPDLALN CCCCCCCCCCCHHHC | 38.02 | 28066266 | |
209 | Phosphorylation | RKMAKFSTPDLALNR CCCCCCCCCCHHHCC | 24.77 | 26643407 | |
245 | Phosphorylation | CVSGPSMSERTSPGT CCCCCCCCCCCCCCC | 28.41 | - | |
248 | Phosphorylation | GPSMSERTSPGTSSA CCCCCCCCCCCCCCC | 34.91 | 24759943 | |
249 | Phosphorylation | PSMSERTSPGTSSAY CCCCCCCCCCCCCCC | 27.79 | 26643407 | |
252 | Phosphorylation | SERTSPGTSSAYTSD CCCCCCCCCCCCCCC | 23.92 | 26643407 | |
253 | Phosphorylation | ERTSPGTSSAYTSDS CCCCCCCCCCCCCCC | 20.91 | 26643407 | |
254 | Phosphorylation | RTSPGTSSAYTSDSP CCCCCCCCCCCCCCC | 25.73 | 26643407 | |
256 | Phosphorylation | SPGTSSAYTSDSPSS CCCCCCCCCCCCCCC | 14.55 | 26643407 | |
257 | Phosphorylation | PGTSSAYTSDSPSSY CCCCCCCCCCCCCCC | 26.27 | 26643407 | |
258 | Phosphorylation | GTSSAYTSDSPSSYH CCCCCCCCCCCCCCC | 24.34 | 26643407 | |
260 | Phosphorylation | SSAYTSDSPSSYHNE CCCCCCCCCCCCCCC | 26.84 | 24759943 | |
262 | Phosphorylation | AYTSDSPSSYHNEED CCCCCCCCCCCCCCC | 47.70 | 26643407 | |
263 | Phosphorylation | YTSDSPSSYHNEEDE CCCCCCCCCCCCCCC | 33.52 | 24759943 | |
264 | Phosphorylation | TSDSPSSYHNEEDEE CCCCCCCCCCCCCCC | 17.01 | 26643407 | |
420 | Phosphorylation | PRRKPLDSRVLHAVK CCCCCCCHHHHHHHH | 31.78 | 19854140 | |
466 | Acetylation | KSWLPKTKPLHLVEG HHCCCCCCCCEEECC | 52.27 | 23806337 | |
476 | Phosphorylation | HLVEGDNYSSFISDT EEECCCCCHHHHHCC | 15.49 | 26643407 | |
477 | Phosphorylation | LVEGDNYSSFISDTC EECCCCCHHHHHCCC | 25.65 | 26643407 | |
478 | Phosphorylation | VEGDNYSSFISDTCK ECCCCCHHHHHCCCC | 19.08 | 25521595 | |
481 | Phosphorylation | DNYSSFISDTCKIEP CCCHHHHHCCCCCCC | 25.51 | 26643407 | |
492 | Phosphorylation | KIEPDMMSMEHSFET CCCCCCCCCCCEEEC | 17.87 | 26643407 | |
496 | Phosphorylation | DMMSMEHSFETASHD CCCCCCCEEECCCCC | 16.09 | 26643407 | |
499 | Phosphorylation | SMEHSFETASHDGEA CCCCEEECCCCCCCC | 31.30 | 26643407 | |
501 | Phosphorylation | EHSFETASHDGEAGP CCEEECCCCCCCCCC | 29.54 | 26643407 | |
509 | Phosphorylation | HDGEAGPSAEVLQ-- CCCCCCCCCCCCC-- | 35.82 | 26643407 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
245 | S | Phosphorylation | Kinase | PKC | - | Uniprot |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NACC1_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NACC1_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
SALL4_MOUSE | Sall4 | physical | 20362541 | |
PO5F1_MOUSE | Pou5f1 | physical | 17093407 | |
ZN281_MOUSE | Zfp281 | physical | 17093407 | |
ARI3A_MOUSE | Arid3a | physical | 17093407 | |
ARI3B_MOUSE | Arid3b | physical | 17093407 | |
NACC2_MOUSE | Nacc2 | physical | 17093407 | |
P66B_MOUSE | Gatad2b | physical | 17093407 | |
WDR18_MOUSE | Wdr18 | physical | 17093407 | |
SMRC1_MOUSE | Smarcc1 | physical | 17093407 | |
SALL4_MOUSE | Sall4 | physical | 17093407 | |
RIF1_MOUSE | Rif1 | physical | 17093407 | |
MBB1A_MOUSE | Mybbp1a | physical | 17093407 | |
NANOG_MOUSE | Nanog | physical | 17093407 | |
TADBP_MOUSE | Tardbp | physical | 23022214 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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