NACC1_MOUSE - dbPTM
NACC1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NACC1_MOUSE
UniProt AC Q7TSZ8
Protein Name Nucleus accumbens-associated protein 1
Gene Name Nacc1
Organism Mus musculus (Mouse).
Sequence Length 514
Subcellular Localization Nucleus. Cytoplasm. Distribution in the cytoplasm is dependent on phosphorylation..
Protein Description Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Involved in the acute behavioral and neurological responses to cocaine and amphetamines..
Protein Sequence MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTFCYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFFLKVSSPSCDSQGLHPEEAPSSEPQSPVAQTLGWPACSTPLPLVSRVKTEQELDSVQCTPMAKRLWDSSQKEAGGSGGNNGSRKMAKFSTPDLALNRMPQPLSMATATAAVAVVAVGGCVSGPSMSERTSPGTSSAYTSDSPSSYHNEEDEEEDAGEEGTDEQYRQICNMYTMYSMLNVGQTAEKVEALPEQVVLESRSRIRVRQDLASLPAELINQIGNRCHPKLYDEGDPSEKLELVTGTNVYITRAQLMNCHVSAGTRHKVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMNAIAADMCTNARRVVRKSWLPKTKPLHLVEGDNYSSFISDTCKIEPDMMSMEHSFETASHDGEAGPSAEVLQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
124PhosphorylationTEFFLKVSSPSCDSQ
CCEEEEECCCCCCCC
34.6425293948
125PhosphorylationEFFLKVSSPSCDSQG
CEEEEECCCCCCCCC
24.6625293948
127PhosphorylationFLKVSSPSCDSQGLH
EEEECCCCCCCCCCC
32.2925293948
130PhosphorylationVSSPSCDSQGLHPEE
ECCCCCCCCCCCCCC
30.4025159016
140PhosphorylationLHPEEAPSSEPQSPV
CCCCCCCCCCCCCCC
55.1525293948
141PhosphorylationHPEEAPSSEPQSPVA
CCCCCCCCCCCCCCH
52.8425159016
145PhosphorylationAPSSEPQSPVAQTLG
CCCCCCCCCCHHHHC
31.8625159016
150PhosphorylationPQSPVAQTLGWPACS
CCCCCHHHHCCCCCC
19.9425159016
157PhosphorylationTLGWPACSTPLPLVS
HHCCCCCCCCCCCCC
34.8625159016
158PhosphorylationLGWPACSTPLPLVSR
HCCCCCCCCCCCCCC
28.8225159016
174PhosphorylationKTEQELDSVQCTPMA
CCHHHHCCCCCCHHH
27.0624759943
178PhosphorylationELDSVQCTPMAKRLW
HHCCCCCCHHHHHHH
10.0624759943
187PhosphorylationMAKRLWDSSQKEAGG
HHHHHHHCCCHHHCC
24.0829514104
188PhosphorylationAKRLWDSSQKEAGGS
HHHHHHCCCHHHCCC
42.6826745281
208PhosphorylationSRKMAKFSTPDLALN
CCCCCCCCCCCHHHC
38.0228066266
209PhosphorylationRKMAKFSTPDLALNR
CCCCCCCCCCHHHCC
24.7726643407
245PhosphorylationCVSGPSMSERTSPGT
CCCCCCCCCCCCCCC
28.41-
248PhosphorylationGPSMSERTSPGTSSA
CCCCCCCCCCCCCCC
34.9124759943
249PhosphorylationPSMSERTSPGTSSAY
CCCCCCCCCCCCCCC
27.7926643407
252PhosphorylationSERTSPGTSSAYTSD
CCCCCCCCCCCCCCC
23.9226643407
253PhosphorylationERTSPGTSSAYTSDS
CCCCCCCCCCCCCCC
20.9126643407
254PhosphorylationRTSPGTSSAYTSDSP
CCCCCCCCCCCCCCC
25.7326643407
256PhosphorylationSPGTSSAYTSDSPSS
CCCCCCCCCCCCCCC
14.5526643407
257PhosphorylationPGTSSAYTSDSPSSY
CCCCCCCCCCCCCCC
26.2726643407
258PhosphorylationGTSSAYTSDSPSSYH
CCCCCCCCCCCCCCC
24.3426643407
260PhosphorylationSSAYTSDSPSSYHNE
CCCCCCCCCCCCCCC
26.8424759943
262PhosphorylationAYTSDSPSSYHNEED
CCCCCCCCCCCCCCC
47.7026643407
263PhosphorylationYTSDSPSSYHNEEDE
CCCCCCCCCCCCCCC
33.5224759943
264PhosphorylationTSDSPSSYHNEEDEE
CCCCCCCCCCCCCCC
17.0126643407
420PhosphorylationPRRKPLDSRVLHAVK
CCCCCCCHHHHHHHH
31.7819854140
466AcetylationKSWLPKTKPLHLVEG
HHCCCCCCCCEEECC
52.2723806337
476PhosphorylationHLVEGDNYSSFISDT
EEECCCCCHHHHHCC
15.4926643407
477PhosphorylationLVEGDNYSSFISDTC
EECCCCCHHHHHCCC
25.6526643407
478PhosphorylationVEGDNYSSFISDTCK
ECCCCCHHHHHCCCC
19.0825521595
481PhosphorylationDNYSSFISDTCKIEP
CCCHHHHHCCCCCCC
25.5126643407
492PhosphorylationKIEPDMMSMEHSFET
CCCCCCCCCCCEEEC
17.8726643407
496PhosphorylationDMMSMEHSFETASHD
CCCCCCCEEECCCCC
16.0926643407
499PhosphorylationSMEHSFETASHDGEA
CCCCEEECCCCCCCC
31.3026643407
501PhosphorylationEHSFETASHDGEAGP
CCEEECCCCCCCCCC
29.5426643407
509PhosphorylationHDGEAGPSAEVLQ--
CCCCCCCCCCCCC--
35.8226643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
245SPhosphorylationKinasePKC-Uniprot

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NACC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NACC1_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SALL4_MOUSESall4physical
20362541
PO5F1_MOUSEPou5f1physical
17093407
ZN281_MOUSEZfp281physical
17093407
ARI3A_MOUSEArid3aphysical
17093407
ARI3B_MOUSEArid3bphysical
17093407
NACC2_MOUSENacc2physical
17093407
P66B_MOUSEGatad2bphysical
17093407
WDR18_MOUSEWdr18physical
17093407
SMRC1_MOUSESmarcc1physical
17093407
SALL4_MOUSESall4physical
17093407
RIF1_MOUSERif1physical
17093407
MBB1A_MOUSEMybbp1aphysical
17093407
NANOG_MOUSENanogphysical
17093407
TADBP_MOUSETardbpphysical
23022214

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NACC1_MOUSE

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Related Literatures of Post-Translational Modification

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