dbPTM

NANOG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NANOG_MOUSE
UniProt AC	Q80Z64
Protein Name	Homeobox protein NANOG
Gene Name	Nanog
Organism	Mus musculus (Mouse).
Sequence Length	305
Subcellular Localization	Nucleus .
Protein Description	Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. [PubMed: 25825768 Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (By similarity Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.]
Protein Sequence	MSVGLPGPHSLPSSEEASNSGNASSMPAVFHPENYSCLQGSATEMLCTEAASPRPSSEDLPLQGSPDSSTSPKQKLSSPEADKGPEEEENKVLARKQKMRTVFSQAQLCALKDRFQKQKYLSLQQMQELSSILNLSYKQVKTWFQNQRMKCKRWQKNQWLKTSNGLIQKGSAPVEYPSIHCSYPQGYLVNASGSLSMWGSQTWTNPTWSSQTWTNPTWNNQTWTNPTWSSQAWTAQSWNGQPWNAAPLHNFGEDFLQPYVQLQQNFSASDLEVNLEATRESHAHFSTPQALELFLNYSVTPPGEI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	EDLPLQGSPDSSTSP CCCCCCCCCCCCCCC	16.75	21149613
68	Phosphorylation	PLQGSPDSSTSPKQK CCCCCCCCCCCCCCC	38.61	21149613
69	Phosphorylation	LQGSPDSSTSPKQKL CCCCCCCCCCCCCCC	40.04	21149613
70	Phosphorylation	QGSPDSSTSPKQKLS CCCCCCCCCCCCCCC	53.66	27149854
71	Phosphorylation	GSPDSSTSPKQKLSS CCCCCCCCCCCCCCC	31.86	21149613
77	Phosphorylation	TSPKQKLSSPEADKG CCCCCCCCCCCHHCC	51.38	29895711
78	Phosphorylation	SPKQKLSSPEADKGP CCCCCCCCCCHHCCC	36.88	29895711
138	Ubiquitination	SILNLSYKQVKTWFQ HHHCCCHHHHHHHHH	45.28	-
169	Ubiquitination	TSNGLIQKGSAPVEY CCCCCCCCCCCCCCC	48.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NANOG_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NANOG_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NANOG_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SALL4_MOUSE	Sall4	physical	17093407
RIF1_MOUSE	Rif1	physical	17093407
TIF1B_MOUSE	Trim28	physical	17093407
MBB1A_MOUSE	Mybbp1a	physical	17093407
NR0B1_MOUSE	Nr0b1	physical	17093407
NACC1_MOUSE	Nacc1	physical	17093407
ZN281_MOUSE	Zfp281	physical	17093407
ERR2_MOUSE	Esrrb	physical	17093407
ELYS_MOUSE	Ahctf1	physical	17093407
PO5F1_MOUSE	Pou5f1	physical	17093407
ZMYM2_MOUSE	Zmym2	physical	17093407
ILF2_MOUSE	Ilf2	physical	17093407
HDAC2_MOUSE	Hdac2	physical	17093407
REST_MOUSE	Rest	physical	17093407
SP1_MOUSE	Sp1	physical	17093407
WAPL_MOUSE	Wapal	physical	17093407
SALL4_MOUSE	Sall4	physical	16840789
ERR2_MOUSE	Esrrb	physical	18454139
P66A_MOUSE	Gatad2a	physical	18454139
P66B_MOUSE	Gatad2b	physical	18454139
HDAC1_MOUSE	Hdac1	physical	18454139
HDAC2_MOUSE	Hdac2	physical	18454139
TIF1B_MOUSE	Trim28	physical	18454139
KDM1A_MOUSE	Kdm1a	physical	18454139
MTA1_MOUSE	Mta1	physical	18454139
MTA2_MOUSE	Mta2	physical	18454139
PO5F1_MOUSE	Pou5f1	physical	18454139
PML_MOUSE	Pml	physical	18454139
RIF1_MOUSE	Rif1	physical	18454139
SALL4_MOUSE	Sall4	physical	18454139
SIN3A_MOUSE	Sin3a	physical	18454139
SMCA2_MOUSE	Smarca2	physical	18454139
SMCA4_MOUSE	Smarca4	physical	18454139
MBD3_MOUSE	Mbd3	physical	18454139
RBBP7_MOUSE	Rbbp7	physical	18454139
SOX2_MOUSE	Sox2	physical	18454139
PIN1_MOUSE	Pin1	physical	20622153
PSD12_MOUSE	Psmd12	physical	21589869
NANOG_MOUSE	Nanog	physical	21589869
PSD11_MOUSE	Psmd11	physical	21589869
PSMD6_MOUSE	Psmd6	physical	21589869
TDIF1_MOUSE	Dnttip1	physical	21589869
NR0B1_MOUSE	Nr0b1	physical	21589869
PSMD2_MOUSE	Psmd2	physical	21589869
LITD1_MOUSE	L1td1	physical	21589869
G3BP2_MOUSE	G3bp2	physical	21589869
PHC1_MOUSE	Phc1	physical	21589869
PRS4_MOUSE	Psmc1	physical	21589869
GDF3_MOUSE	Gdf3	physical	21589869
NACC1_MOUSE	Nacc1	physical	21589869
ODPB_MOUSE	Pdhb	physical	21589869
SALL4_MOUSE	Sall4	physical	21589869
STAG1_MOUSE	Stag1	physical	21589869
PML_MOUSE	Pml	physical	21589869
ZN281_MOUSE	Zfp281	physical	21589869
TRIPC_MOUSE	Trip12	physical	21589869
MSH2_MOUSE	Msh2	physical	21589869
NOL6_MOUSE	Nol6	physical	21589869
MSH6_MOUSE	Msh6	physical	21589869
TBX3_MOUSE	Tbx3	physical	21589869
TIF1B_MOUSE	Trim28	physical	21589869
ARI5B_MOUSE	Arid5b	physical	21589869
ABCF2_MOUSE	Abcf2	physical	21589869
K1C16_MOUSE	Krt16	physical	21589869
FBX30_MOUSE	Fbxo30	physical	21589869
PSMD7_MOUSE	Psmd7	physical	21589869
DNM3A_MOUSE	Dnmt3a	physical	21589869
TEX10_MOUSE	Tex10	physical	21589869
RIF1_MOUSE	Rif1	physical	21589869
EFTU_MOUSE	Tufm	physical	21589869
MTA2_MOUSE	Mta2	physical	21589869
TRI27_MOUSE	Trim27	physical	21589869
HDAC1_MOUSE	Hdac1	physical	21589869
K1C9_MOUSE	Krt9	physical	21589869
ATX2L_MOUSE	Atxn2l	physical	21589869
EED_MOUSE	Eed	physical	21589869
SENP3_MOUSE	Senp3	physical	21589869
NUFP2_MOUSE	Nufip2	physical	21589869
UHRF1_MOUSE	Uhrf1	physical	21589869
HSPB1_MOUSE	Hspb1	physical	21589869
G3P_MOUSE	Gapdh	physical	21589869
NVL_MOUSE	Nvl	physical	21589869
IF2B1_MOUSE	Igf2bp1	physical	21589869
CDC73_MOUSE	Cdc73	physical	21589869
TSR1_MOUSE	Tsr1	physical	21589869
PABP1_MOUSE	Pabpc1	physical	21589869
CSK21_MOUSE	Csnk2a1	physical	21589869
KAT7_MOUSE	Kat7	physical	21589869
TREF1_MOUSE	Trerf1	physical	21589869
WDR18_MOUSE	Wdr18	physical	21589869
K2C5_MOUSE	Krt5	physical	21589869
TBA4A_MOUSE	Tuba4a	physical	21589869
ANM5_MOUSE	Prmt5	physical	21589869
MBD3_MOUSE	Mbd3	physical	21589869
XPO4_MOUSE	Xpo4	physical	21589869
K2C1_MOUSE	Krt1	physical	21589869
HELLS_MOUSE	Hells	physical	21589869
WAPL_MOUSE	Wapal	physical	21589869
MOV10_MOUSE	Mov10	physical	21589869
PELP1_MOUSE	Pelp1	physical	21589869
SSRP1_MOUSE	Ssrp1	physical	21589869
CH60_MOUSE	Hspd1	physical	21589869
GNL3_MOUSE	Gnl3	physical	21589869
DNM3L_MOUSE	Dnmt3l	physical	21589869
PFKAP_MOUSE	Pfkp	physical	21589869
RS27_MOUSE	Rps27	physical	21589869
MCM3_MOUSE	Mcm3	physical	21589869
ORC1_MOUSE	Orc1	physical	21589869
POGZ_MOUSE	Pogz	physical	21589869
CHD4_MOUSE	Chd4	physical	21589869
FXR1_MOUSE	Fxr1	physical	21589869
RFC4_MOUSE	Rfc4	physical	21589869
PSIP1_MOUSE	Psip1	physical	21589869
RING2_MOUSE	Rnf2	physical	21589869
NONO_MOUSE	Nono	physical	21589869
TLR4_MOUSE	Tlr4	physical	21589869
RBBP4_MOUSE	Rbbp4	physical	21589869
RFC2_MOUSE	Rfc2	physical	21589869
TOP2A_MOUSE	Top2a	physical	21589869
RUVB1_MOUSE	Ruvbl1	physical	21589869
PRS6B_MOUSE	Psmc4	physical	21589869
ZSC10_MOUSE	Zscan10	physical	21589869
SOX2_MOUSE	Sox2	physical	21589869
IF6_MOUSE	Eif6	physical	21589869
DNJA1_MOUSE	Dnaja1	physical	21589869
CAZA1_MOUSE	Capza1	physical	21589869
DDX27_MOUSE	Ddx27	physical	21589869
PSMD1_MOUSE	Psmd1	physical	21589869
CAZA2_MOUSE	Capza2	physical	21589869
RUVB2_MOUSE	Ruvbl2	physical	21589869
CMC2_MOUSE	Slc25a13	physical	21589869
SP16H_MOUSE	Supt16	physical	21589869
DIDO1_MOUSE	Dido1	physical	21589869
RTCB_MOUSE	Rtcb	physical	21589869
LAS1L_MOUSE	Las1l	physical	21589869
TBB4B_MOUSE	Tubb4b	physical	21589869
THOC5_MOUSE	Thoc5	physical	21589869
MYO1E_MOUSE	Myo1e	physical	21589869
TDIF2_MOUSE	Dnttip2	physical	21589869
TDH_MOUSE	Tdh	physical	21589869
CAPZB_MOUSE	Capzb	physical	21589869
RS3_MOUSE	Rps3	physical	21589869
RBM14_MOUSE	Rbm14	physical	21589869
TBB2B_MOUSE	Tubb2b	physical	21589869
IMB1_MOUSE	Kpnb1	physical	21589869
CBX1_MOUSE	Cbx1	physical	21589869
GNL3L_MOUSE	Gnl3l	physical	21589869
NSUN2_MOUSE	Nsun2	physical	21589869
BYST_MOUSE	Bysl	physical	21589869
RFC5_MOUSE	Rfc5	physical	21589869
DNM3B_MOUSE	Dnmt3b	physical	21589869
NIP7_MOUSE	Nip7	physical	21589869
SSF1_MOUSE	Ppan	physical	21589869
NOP14_MOUSE	Nop14	physical	21589869
RPAB3_MOUSE	Polr2h	physical	21589869
VIR_MOUSE	1110037F02Rik	physical	21589869
RS29_MOUSE	Rps29	physical	21589869
TBA1A_MOUSE	Tuba1a	physical	21589869
NOG1_MOUSE	Gtpbp4	physical	21589869
DPY30_MOUSE	Dpy30	physical	21589869
RCC2_MOUSE	Rcc2	physical	21589869
AHDC1_MOUSE	Ahdc1	physical	21589869
SMCA5_MOUSE	Smarca5	physical	21589869
NFKB2_MOUSE	Nfkb2	physical	18223644
TF65_MOUSE	Rela	physical	18223644
RELB_MOUSE	Relb	physical	18223644
NANOG_MOUSE	Nanog	physical	18223644
SALL4_MOUSE	Sall4	physical	23892456
MTA2_MOUSE	Mta2	physical	23892456
SOX2_MOUSE	Sox2	physical	23892456
NACC1_MOUSE	Nacc1	physical	23892456
RPB1_MOUSE	Polr2a	physical	23892456
BRMS1_MOUSE	Brms1	physical	23892456
MGAP_MOUSE	Mga	physical	23892456
SP130_MOUSE	Sap130	physical	23892456
KMT2B_MOUSE	Kmt2b	physical	23892456
CHD7_MOUSE	Chd7	physical	23892456
CSK21_MOUSE	Csnk2a1	physical	23892456
TPX2_MOUSE	Tpx2	physical	23892456
INT13_MOUSE	Asun	physical	23892456
BAP18_MOUSE	0610010K14Rik	physical	23892456
DFFB_MOUSE	Dffb	physical	23892456
SKT_MOUSE	Etl4	physical	23892456
NANOG_MOUSE	Nanog	physical	23892456
ERR2_MOUSE	Esrrb	physical	23892456
NR0B1_MOUSE	Nr0b1	physical	23892456
MYEF2_MOUSE	Myef2	physical	23892456
ZN281_MOUSE	Zfp281	physical	23892456
ZFP42_MOUSE	Zfp42	physical	23892456
ARI3B_MOUSE	Arid3b	physical	23892456
SMCA5_MOUSE	Smarca5	physical	23892456
CXXC5_MOUSE	Cxxc5	physical	23892456
ZN326_MOUSE	Zfp326	physical	23892456
SALL3_MOUSE	Sall3	physical	23892456
ZIC3_MOUSE	Zic3	physical	23892456
ZN609_MOUSE	Zfp609	physical	23892456
BNC2_MOUSE	Bnc2	physical	23892456
FIZ1_MOUSE	Fiz1	physical	23892456
ARI5B_MOUSE	Arid5b	physical	23892456
KLF5_MOUSE	Klf5	physical	23892456
GRHL2_MOUSE	Grhl2	physical	23892456
MBD3_MOUSE	Mbd3	physical	23892456
P66A_MOUSE	Gatad2a	physical	23892456
P66B_MOUSE	Gatad2b	physical	23892456
MTA3_MOUSE	Mta3	physical	23892456
CHD4_MOUSE	Chd4	physical	23892456
MTA1_MOUSE	Mta1	physical	23892456
MBD2_MOUSE	Mbd2	physical	23892456
YETS4_MOUSE	Yeats4	physical	23892456
DMAP1_MOUSE	Dmap1	physical	23892456
VPS72_MOUSE	Vps72	physical	23892456
EP400_MOUSE	Ep400	physical	23892456
BRD8_MOUSE	Brd8	physical	23892456
RING2_MOUSE	Rnf2	physical	23892456
RYBP_MOUSE	Rybp	physical	23892456
PHC1_MOUSE	Phc1	physical	23892456
PCGF6_MOUSE	Pcgf6	physical	23892456
MBTD1_MOUSE	Mbtd1	physical	23892456
EZH2_MOUSE	Ezh2	physical	23892456
LMBL2_MOUSE	L3mbtl2	physical	23892456
EHMT1_MOUSE	Ehmt1	physical	23892456
EHMT2_MOUSE	Ehmt2	physical	23892456
SIN3A_MOUSE	Sin3a	physical	23892456
HCFC1_MOUSE	Hcfc1	physical	23892456
TBL1R_MOUSE	Tbl1xr1	physical	23892456
TBL1X_MOUSE	Tbl1x	physical	23892456
KDM1A_MOUSE	Kdm1a	physical	23892456
ZMYM2_MOUSE	Zmym2	physical	23892456
ASH2L_MOUSE	Ash2l	physical	23892456
KAT8_MOUSE	Kat8	physical	23892456
RBBP5_MOUSE	Rbbp5	physical	23892456
MEN1_MOUSE	Men1	physical	23892456
MO4L1_MOUSE	Morf4l1	physical	23892456
RCOR2_MOUSE	Rcor2	physical	23892456
H12_MOUSE	Hist1h1c	physical	23892456
WIZ_MOUSE	Wiz	physical	23892456
CNOT1_MOUSE	Cnot1	physical	23892456
TET1_MOUSE	Tet1	physical	23892456
HIRA_MOUSE	Hira	physical	23892456
ARI1A_MOUSE	Arid1a	physical	23892456
BCOR_MOUSE	Bcor	physical	23892456
WDR82_MOUSE	Wdr82	physical	23892456
TAF9_MOUSE	Taf9	physical	23892456
SPT6H_MOUSE	Supt6	physical	23892456
INT1_MOUSE	Ints1	physical	23892456
RPB2_MOUSE	Polr2b	physical	23892456
AKAP8_MOUSE	Akap8	physical	23892456
KC1A_MOUSE	Csnk1a1	physical	23892456
2AAA_MOUSE	Ppp2r1a	physical	23892456
CHIP_MOUSE	Stub1	physical	23892456
UCHL5_MOUSE	Uchl5	physical	23892456
RAGP1_MOUSE	Rangap1	physical	23892456
PSD11_MOUSE	Psmd11	physical	23892456
RBP2_MOUSE	Ranbp2	physical	23892456
RALY_MOUSE	Raly	physical	23892456
HNRH2_MOUSE	Hnrnph2	physical	23892456
ILF3_MOUSE	Ilf3	physical	23892456
EXOS6_MOUSE	Exosc6	physical	23892456
RBM4B_MOUSE	Rbm4b	physical	23892456
DHX9_MOUSE	Dhx9	physical	23892456
RFOX2_MOUSE	Rbfox2	physical	23892456
ZCHC8_MOUSE	Zcchc8	physical	23892456
DDX1_MOUSE	Ddx1	physical	23892456
PUM1_MOUSE	Pum1	physical	23892456
WDR33_MOUSE	Wdr33	physical	23892456
INT4_MOUSE	Ints4	physical	23892456
MOV10_MOUSE	Mov10	physical	23892456
PUM2_MOUSE	Pum2	physical	23892456
RFC4_MOUSE	Rfc4	physical	23892456
MD1L1_MOUSE	Mad1l1	physical	23892456
GTSE1_MOUSE	Gtse1	physical	23892456
ORC5_MOUSE	Orc5	physical	23892456
SGO2_MOUSE	Sgol2	physical	23892456
SMC3_MOUSE	Smc3	physical	23892456
POGZ_MOUSE	Pogz	physical	23892456
MSH6_MOUSE	Msh6	physical	23892456
BRCA1_MOUSE	Brca1	physical	23892456
EMSY_MOUSE	2210018M11Rik	physical	23892456
BRCA2_MOUSE	Brca2	physical	23892456
DNJA1_MOUSE	Dnaja1	physical	23892456
DCAF7_MOUSE	Dcaf7	physical	23892456
SEC13_MOUSE	Sec13	physical	23892456
REQU_MOUSE	Dpf2	physical	23892456
TDIF1_MOUSE	Dnttip1	physical	23892456
ZFR_MOUSE	Zfr	physical	23892456
IMA1_MOUSE	Kpna2	physical	23892456
MK03_MOUSE	Mapk3	physical	24793005
MK01_MOUSE	Mapk1	physical	24793005
FBXW4_MOUSE	Fbxw4	physical	24793005
FBXW5_MOUSE	Fbxw5	physical	24793005
FBXW8_MOUSE	Fbxw8	physical	24793005
ZN609_MOUSE	Zfp609	physical	23395962
EMSY_MOUSE	2210018M11Rik	physical	23395962
NACC1_MOUSE	Nacc1	physical	23395962
JHD2C_MOUSE	Jmjd1c	physical	23395962
BRCA2_MOUSE	Brca2	physical	23395962
TET1_MOUSE	Tet1	physical	23395962
NCOR2_MOUSE	Ncor2	physical	23395962
HNRPM_MOUSE	Hnrnpm	physical	23395962
P66A_MOUSE	Gatad2a	physical	23395962
ARI3B_MOUSE	Arid3b	physical	23395962
HDAC2_MOUSE	Hdac2	physical	23395962
SK2L2_MOUSE	Skiv2l2	physical	23395962
PO5F1_MOUSE	Pou5f1	physical	23395962
LMNB1_MOUSE	Lmnb1	physical	23395962
MTA2_MOUSE	Mta2	physical	23395962
SALL4_MOUSE	Sall4	physical	23395962
MTA3_MOUSE	Mta3	physical	23395962
SMC3_MOUSE	Smc3	physical	23395962
WDR18_MOUSE	Wdr18	physical	23395962
UBP21_MOUSE	Usp21	physical	27886188

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NANOG_MOUSE

Related Literatures of Post-Translational Modification