| UniProt ID | WDR82_MOUSE | |
|---|---|---|
| UniProt AC | Q8BFQ4 | |
| Protein Name | WD repeat-containing protein 82 | |
| Gene Name | Wdr82 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 313 | |
| Subcellular Localization | Nucleus. Associates with chromatin.. | |
| Protein Description | Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Possible role in telomere length maintenance and in mRNA processing (By similarity).. | |
| Protein Sequence | MKLTDSVLRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MKLTDSVLRSFRV --CCCCHHHHHHHHH | 20.16 | 26643407 | |
| 10 | Phosphorylation | LTDSVLRSFRVAKVF CCHHHHHHHHHHHHH | 17.16 | 26643407 | |
| 63 | Ubiquitination | KRTLYSKKYGVDLIR CCEEECCCCCCCEEE | 41.10 | - | |
| 64 | Phosphorylation | RTLYSKKYGVDLIRY CEEECCCCCCCEEEE | 26.56 | - | |
| 84 | Ubiquitination | TVVYSSNKIDDTIRY EEEEECCCHHCEEEE | 49.84 | - | |
| 154 | Phosphorylation | LQGKPVCSFDPEGLI ECCCCCCEECCCCCE | 32.68 | 17203969 | |
| 168 | Phosphorylation | IFAAGVNSEMVKLYD EEEEECCHHHEEEEC | 25.35 | 28285833 | |
| 181 | Ubiquitination | YDLRSFDKGPFATFK ECCCCCCCCCCCEEE | 67.48 | - | |
| 212 | Phosphorylation | DGKLILISTNGSFIR CCCEEEEECCCHHHH | 16.63 | 28059163 | |
| 235 | Phosphorylation | VMHTFGGYANSKAVT EEEECCCCCCCCEEE | 11.73 | 28059163 | |
| 280 | Ubiquitination | KVAVLDGKHTGPITC EEEEECCCCCCCEEE | 37.35 | - | |
| 280 | Acetylation | KVAVLDGKHTGPITC EEEEECCCCCCCEEE | 37.35 | 22826441 | |
| 287 | S-nitrosocysteine | KHTGPITCLQFNPKF CCCCCEEEEEECHHH | 2.66 | - | |
| 287 | S-nitrosylation | KHTGPITCLQFNPKF CCCCCEEEEEECHHH | 2.66 | 20925432 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WDR82_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WDR82_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WDR82_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of WDR82_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154, AND MASSSPECTROMETRY. | |
