dbPTM

FIZ1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FIZ1_MOUSE
UniProt AC	Q9WTJ4
Protein Name	Flt3-interacting zinc finger protein 1
Gene Name	Fiz1
Organism	Mus musculus (Mouse).
Sequence Length	500
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity)..
Protein Sequence	MEDSSLPVVPAPIAAPGPAPSATAPRVPFHCSECGKSFRYRSDLRRHFARHTALKPHACPRCGKGFKHSFNLANHLRSHTGERPYRCSACPKGFRDSTGLLHHQVVHTGEKPYCCLVCELRFSSRSSLGRHLKRQHRGTLPSPLQPSPGLPPLSSPCSVCCNVGPCSVCGGGGSSGGEGLEGAGATSWGLAEAAAAAAASLPPFACGACARRFDHGRELAAHWAAHTDVKPFKCPRCERDFNAPALLERHKLTHDLQGSNAPPTQVWASGGGPEVAGEGDASEVGAAPQTWDAGLLLSPTGAGVPKLEALLPGDEGSGNDQAPAAAAEASSEDTLYQCDCGTFFASAPALASHLEAHSGPATYGCGHCGALYAALAALEEHRRASHGEGSGEAAPDGEGNQAAGGPGPGSSSRSKKIFGCSECEKLFRSPRDLERHVLVHTGEKPFPCLECGKFFRHECYLKRHRLLHGTERPFPCHICGKGFITLSNLSRHLKLHRGMD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDSSLPV -------CCCCCCCC	13.41	-
108	Phosphorylation	LHHQVVHTGEKPYCC CCEEEEECCCCCEEE	35.11	23140645
385	Phosphorylation	LEEHRRASHGEGSGE HHHHHHHHCCCCCCC	30.16	-
441	Phosphorylation	ERHVLVHTGEKPFPC HCCEEEECCCCCCCE	39.29	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FIZ1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FIZ1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FIZ1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
FLT3_MOUSE	Flt3	physical	10409713

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FIZ1_MOUSE

Related Literatures of Post-Translational Modification