dbPTM

AHDC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AHDC1_MOUSE
UniProt AC	Q6PAL7
Protein Name	AT-hook DNA-binding motif-containing protein 1
Gene Name	Ahdc1
Organism	Mus musculus (Mouse).
Sequence Length	1594
Subcellular Localization
Protein Description
Protein Sequence	MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPPASPPDKAFSTHTFSENPRPPPRRDPSSRRPPVLAKGDDLLPPRAARPVSQAHCPSPAPDNSSLRHWDNGRVNLRPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPGDLQYSFFSSPSLANSIRSPEERANPHTKSERPSHPLYEPEPEPRDSPQPGQGHGPGAAATATGLPPEPEPDGPDYSELADADILSELASLTCPEAQLLEAQALEPPSPQPEPQLLDPQPRFLDPQALEPLGEGLELPPLQPLADPLGLPSLTLQALDTLPDSLESQLLDPQALDPLPKLLDVPGRRLEPQQSLGHCQLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKILCRRRKAGRGRKADSGPEGRLLPLPMPTGLAAALAEPPPLPPPPPPTLSGPGPVPELEPESSQTPMVPTRKGKCRGVRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLRVSSEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPTVVAAEAATVTAATMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQCAGRCSPPRCWTPSEPESVHQAPDTQSISQFLHRVQGFRRRGGKTGGFGGRGGGHAAKAARCSFSDFFEGIGKKKKVVAVAAPGLVGPGLTELGHPRKRGRGEVDAVTGKPKRKRRSRKNGTLFPEQVPSGPGFGEAGAEWVGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFASTGLESGASGRGSYYAGAPSGQTELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASRPESRKASGTYAGPPSSALPAQRGLATFPSRGAKASPVAVGSSGAGADPSFQPVLPSRQTFPPGRATSYGITPATSDCRAAETFPKLAPPPSAVARSPTTHPPANTYPPQYGGYGAGQSVFASAKPFSGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKASFFNSSEGGPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASAASVASSSSSSFQPSPENCRQFVGASQWPFRQGYGGLDWASEAFSQLYNPNFDCHGSEPNVILDISNYTPQKVKQQTAVSETFSESSSDSTQFSQPVGGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASSAPGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFSTSTSATASGYPSKRSTGPRQPRGGRGSGACSAKKERGGTAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQSRAFGVGERDPCDFMGPYSMNPSTPSDGTFGQGFHCDSPSLGAAELDGKHFPPLAHPPTVFDAGLQKAYSPTCSPTLGFKEELRPPPSKLTACEPLKHGLQGASLSHAAQAHLSCRDLPLGQPHYDSPSCKGTAYWYPPGSAARSPPYEGKVGSGLLADFLGRTEAVCLSAPHLASPPATPKADKEPLEMARPPGPPRGPAAATAGYGCPLLSDLTLSPVPRDSLLPLQDTAYRYPGFMPQAHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	PQGLVVTSSAVCSSP CCCEEEECCCCCCCC	12.51	26643407
13	Phosphorylation	QGLVVTSSAVCSSPD CCEEEECCCCCCCCH	18.50	26643407
17	Phosphorylation	VTSSAVCSSPDYLRE EECCCCCCCCHHHCC	38.00	26643407
18	Phosphorylation	TSSAVCSSPDYLREP ECCCCCCCCHHHCCC	19.36	26643407
21	Phosphorylation	AVCSSPDYLREPKYY CCCCCCHHHCCCCCC	15.84	26643407
34	Phosphorylation	YYPGGPPTPRPLLPT CCCCCCCCCCCCCCC	34.75	26643407
41	Phosphorylation	TPRPLLPTRPPASPP CCCCCCCCCCCCCCC	56.64	26643407
46	Phosphorylation	LPTRPPASPPDKAFS CCCCCCCCCCCCCCC	42.62	26824392
70	Phosphorylation	PPPRRDPSSRRPPVL CCCCCCCHHCCCCCC	40.54	19367708
71	Phosphorylation	PPRRDPSSRRPPVLA CCCCCCHHCCCCCCC	37.38	36520437
79	Acetylation	RRPPVLAKGDDLLPP CCCCCCCCCCCCCCH	59.73	23806337
93	Phosphorylation	PRAARPVSQAHCPSP HHHCCCCCCCCCCCC	25.08	29472430
99	Phosphorylation	VSQAHCPSPAPDNSS CCCCCCCCCCCCCCC	38.80	28418008
105	Phosphorylation	PSPAPDNSSLRHWDN CCCCCCCCCCCCCCC	37.82	29550500
106	Phosphorylation	SPAPDNSSLRHWDNG CCCCCCCCCCCCCCC	35.36	29550500
134	Phosphorylation	MKDLTRLSQDLQHSG HHHHHHHHHHHHHCC	20.54	29514104
168	Phosphorylation	DLQYSFFSSPSLANS CCCEEECCCHHHHHH	39.05	26643407
169	Phosphorylation	LQYSFFSSPSLANSI CCEEECCCHHHHHHC	17.22	26643407
171	Phosphorylation	YSFFSSPSLANSIRS EEECCCHHHHHHCCC	41.90	26643407
175	Phosphorylation	SSPSLANSIRSPEER CCHHHHHHCCCHHHH	17.48	26643407
178	Phosphorylation	SLANSIRSPEERANP HHHHHCCCHHHHCCC	34.69	26643407
267	Phosphorylation	AQALEPPSPQPEPQL HHCCCCCCCCCCCCC	47.05	-
368	Phosphorylation	PLRLDLCSPHGPPGP CCCCEECCCCCCCCC	27.51	28066266
493	Phosphorylation	NKTTYKVSSLSSSLS CCCEEEEEECCCCEE	22.78	26643407
494	Phosphorylation	KTTYKVSSLSSSLSV CCEEEEEECCCCEEE	34.95	26643407
496	Phosphorylation	TYKVSSLSSSLSVEG EEEEEECCCCEEECC	21.59	26643407
497	Phosphorylation	YKVSSLSSSLSVEGK EEEEECCCCEEECCE	40.36	26643407
498	Phosphorylation	KVSSLSSSLSVEGKE EEEECCCCEEECCEE	22.68	26643407
500	Phosphorylation	SSLSSSLSVEGKELG EECCCCEEECCEEEC	21.77	26643407
593	Phosphorylation	RRKQKLASPQPSYAA HHHHHHCCCCCCCCC	34.21	25521595
597	Phosphorylation	KLASPQPSYAADAND HHCCCCCCCCCCCCC	23.35	25619855
598	Phosphorylation	LASPQPSYAADANDS HCCCCCCCCCCCCCC	16.70	23984901
630	Phosphorylation	SQCAGRCSPPRCWTP CCCCCCCCCCCCCCC	36.26	23684622
636	Phosphorylation	CSPPRCWTPSEPESV CCCCCCCCCCCCCCC	22.14	9478467
638	Phosphorylation	PPRCWTPSEPESVHQ CCCCCCCCCCCCCCC	59.41	22817900
642	Phosphorylation	WTPSEPESVHQAPDT CCCCCCCCCCCCCCC	35.30	20415495
669	Phosphorylation	FRRRGGKTGGFGGRG HHHCCCCCCCCCCCC	45.90	22817900
675	Methylation	KTGGFGGRGGGHAAK CCCCCCCCCCHHHHH	40.75	-
687	Phosphorylation	AAKAARCSFSDFFEG HHHHHHCCHHHHHHC	23.41	73666045
732	Phosphorylation	RGEVDAVTGKPKRKR CCCCCCCCCCCCCCC	41.00	52836401
801	Phosphorylation	EARAFASTGLESGAS HHHHHHCCCCCCCCC	42.21	22871156
805	Phosphorylation	FASTGLESGASGRGS HHCCCCCCCCCCCCC	44.71	22871156
825	Phosphorylation	PSGQTELSQERQNLF CCCCCHHHHHHHHHH	24.62	17525332
838	Phosphorylation	LFTGYFRSLLDSDDS HHHHHHHHHCCCCCH	24.32	21149613
842	Phosphorylation	YFRSLLDSDDSSDLL HHHHHCCCCCHHHHH	43.20	21082442
845	Phosphorylation	SLLDSDDSSDLLDFA HHCCCCCHHHHHHHH	30.64	21082442
846	Phosphorylation	LLDSDDSSDLLDFAL HCCCCCHHHHHHHHH	38.99	26239621
854	Phosphorylation	DLLDFALSASRPESR HHHHHHHHCCCCCHH	22.29	25293948
856	Phosphorylation	LDFALSASRPESRKA HHHHHHCCCCCHHHC	45.02	25293948
860	Phosphorylation	LSASRPESRKASGTY HHCCCCCHHHCCCCC	41.59	25293948
864	Phosphorylation	RPESRKASGTYAGPP CCCHHHCCCCCCCCH	34.40	28833060
866	Phosphorylation	ESRKASGTYAGPPSS CHHHCCCCCCCCHHH	14.01	28833060
867	Phosphorylation	SRKASGTYAGPPSSA HHHCCCCCCCCHHHC	17.06	28833060
872	Phosphorylation	GTYAGPPSSALPAQR CCCCCCHHHCCCCHH	31.23	28833060
887	Methylation	GLATFPSRGAKASPV CCCCCCCCCCCCCCE	49.69	-
892	Phosphorylation	PSRGAKASPVAVGSS CCCCCCCCCEEECCC	21.14	23527152
898	Phosphorylation	ASPVAVGSSGAGADP CCCEEECCCCCCCCC	20.99	25293948
899	Phosphorylation	SPVAVGSSGAGADPS CCEEECCCCCCCCCC	27.08	25293948
906	Phosphorylation	SGAGADPSFQPVLPS CCCCCCCCCCCCCCC	36.74	21149613
913	Phosphorylation	SFQPVLPSRQTFPPG CCCCCCCCCCCCCCC	32.62	21149613
942	Acetylation	RAAETFPKLAPPPSA CHHHHCCCCCCCCCH	53.76	23806337
948	Phosphorylation	PKLAPPPSAVARSPT CCCCCCCCHHCCCCC	40.94	26643407
953	Phosphorylation	PPSAVARSPTTHPPA CCCHHCCCCCCCCCC	19.50	25293948
955	Phosphorylation	SAVARSPTTHPPANT CHHCCCCCCCCCCCC	38.70	26643407
956	Phosphorylation	AVARSPTTHPPANTY HHCCCCCCCCCCCCC	35.45	25293948
962	Phosphorylation	TTHPPANTYPPQYGG CCCCCCCCCCCCCCC	39.24	25293948
963	Phosphorylation	THPPANTYPPQYGGY CCCCCCCCCCCCCCC	16.84	25293948
967	Phosphorylation	ANTYPPQYGGYGAGQ CCCCCCCCCCCCCCH	20.49	26643407
970	Phosphorylation	YPPQYGGYGAGQSVF CCCCCCCCCCCHHHC	10.23	26643407
975	Phosphorylation	GGYGAGQSVFASAKP CCCCCCHHHCEECCC	20.48	26643407
995	Phosphorylation	CANSKDCSFAYGSGN CCCCCCCCEECCCCC	24.05	25293948
998	Phosphorylation	SKDCSFAYGSGNSLP CCCCCEECCCCCCCC	15.15	25293948
1000	Phosphorylation	DCSFAYGSGNSLPAS CCCEECCCCCCCCCC	23.33	26643407
1003	Phosphorylation	FAYGSGNSLPASPSS EECCCCCCCCCCCCC	38.98	25293948
1007	Phosphorylation	SGNSLPASPSSAHSA CCCCCCCCCCCCCCC	24.31	25293948
1009	Phosphorylation	NSLPASPSSAHSAGY CCCCCCCCCCCCCCC	37.35	26643407
1010	Phosphorylation	SLPASPSSAHSAGYA CCCCCCCCCCCCCCC	33.13	25293948
1013	Phosphorylation	ASPSSAHSAGYAPPP CCCCCCCCCCCCCCC	24.09	25293948
1016	Phosphorylation	SSAHSAGYAPPPTGG CCCCCCCCCCCCCCC	18.69	25293948
1021	Phosphorylation	AGYAPPPTGGPCLPP CCCCCCCCCCCCCCC	61.62	25293948
1048	Phosphorylation	PFSGSAPTPLRCDSR CCCCCCCCCCCCCCC	34.37	22006019
1054	Phosphorylation	PTPLRCDSRASTVSP CCCCCCCCCCCEECC	33.11	29514104
1057	Phosphorylation	LRCDSRASTVSPGGY CCCCCCCCEECCCCE	28.38	28833060
1058	Phosphorylation	RCDSRASTVSPGGYM CCCCCCCEECCCCEE	24.82	27180971
1060	Phosphorylation	DSRASTVSPGGYMVP CCCCCEECCCCEECC	20.23	26824392
1064	Phosphorylation	STVSPGGYMVPKGTT CEECCCCEECCCCCC	10.80	28833060
1083	Phosphorylation	SVASSSSSSFQPSPE HHHHCCCCCCCCCCC	36.80	29899451
1084	Phosphorylation	VASSSSSSFQPSPEN HHHCCCCCCCCCCCH	29.83	25293948
1088	Phosphorylation	SSSSFQPSPENCRQF CCCCCCCCCCHHHHH	33.78	24453211
1180	Phosphorylation	GGFRRANSEASSSEG CCCCCCCCCCCCCCC	33.29	27742792
1183	Phosphorylation	RRANSEASSSEGQSS CCCCCCCCCCCCCCC	30.28	25266776
1184	Phosphorylation	RANSEASSSEGQSSL CCCCCCCCCCCCCCH	39.18	26643407
1185	Phosphorylation	ANSEASSSEGQSSLS CCCCCCCCCCCCCHH	43.16	25521595
1192	Phosphorylation	SEGQSSLSSLEKLMM CCCCCCHHHHHHHHC	34.52	27149854
1193	Phosphorylation	EGQSSLSSLEKLMMD CCCCCHHHHHHHHCC	45.93	27149854
1309	Phosphorylation	SPDLGLDYYSGDSSM CCCCCCCCCCCCCCC	12.46	26643407
1310	Phosphorylation	PDLGLDYYSGDSSMS CCCCCCCCCCCCCCC	13.07	26643407
1311	Phosphorylation	DLGLDYYSGDSSMSP CCCCCCCCCCCCCCC	29.87	26643407
1314	Phosphorylation	LDYYSGDSSMSPLPS CCCCCCCCCCCCCCC	31.31	21082442
1315	Phosphorylation	DYYSGDSSMSPLPSQ CCCCCCCCCCCCCCC	28.19	26643407
1317	Phosphorylation	YSGDSSMSPLPSQSR CCCCCCCCCCCCCCC	25.82	26643407
1321	Phosphorylation	SSMSPLPSQSRAFGV CCCCCCCCCCCCCCC	48.77	26643407
1323	Phosphorylation	MSPLPSQSRAFGVGE CCCCCCCCCCCCCCC	29.88	26643407
1346	Phosphorylation	PYSMNPSTPSDGTFG CCCCCCCCCCCCCCC	28.24	51458885
1348	Phosphorylation	SMNPSTPSDGTFGQG CCCCCCCCCCCCCCC	49.08	51458879
1360	Phosphorylation	GQGFHCDSPSLGAAE CCCCCCCCCCCCCEE	23.06	51458897
1391	Phosphorylation	DAGLQKAYSPTCSPT CCCCCHHCCCCCCCC	23.40	25521595
1392	Phosphorylation	AGLQKAYSPTCSPTL CCCCHHCCCCCCCCC	20.70	25521595
1394	Phosphorylation	LQKAYSPTCSPTLGF CCHHCCCCCCCCCCC	21.48	27087446
1396	Phosphorylation	KAYSPTCSPTLGFKE HHCCCCCCCCCCCCH	24.33	27087446
1398	Phosphorylation	YSPTCSPTLGFKEEL CCCCCCCCCCCCHHH	24.18	27742792
1447	Phosphorylation	LPLGQPHYDSPSCKG CCCCCCCCCCCCCCC	25.46	28066266
1449	Phosphorylation	LGQPHYDSPSCKGTA CCCCCCCCCCCCCCE	16.14	25266776
1451	Phosphorylation	QPHYDSPSCKGTAYW CCCCCCCCCCCCEEE	32.20	28066266
1459	Phosphorylation	CKGTAYWYPPGSAAR CCCCEEEECCCCHHC	6.20	26643407
1463	Phosphorylation	AYWYPPGSAARSPPY EEEECCCCHHCCCCC	25.24	27600695
1467	Phosphorylation	PPGSAARSPPYEGKV CCCCHHCCCCCCCCC	26.04	27149854
1470	Phosphorylation	SAARSPPYEGKVGSG CHHCCCCCCCCCCCC	40.47	26745281
1476	Phosphorylation	PYEGKVGSGLLADFL CCCCCCCCCHHHHHH	29.29	26643407
1486	Phosphorylation	LADFLGRTEAVCLSA HHHHHCCCCEEECCC	26.88	28833060
1492	Phosphorylation	RTEAVCLSAPHLASP CCCEEECCCHHHCCC	34.33	28833060
1498	Phosphorylation	LSAPHLASPPATPKA CCCHHHCCCCCCCCC	37.46	25521595
1502	Phosphorylation	HLASPPATPKADKEP HHCCCCCCCCCCCCC	30.97	25521595
1526	Phosphorylation	PRGPAAATAGYGCPL CCCHHHHCCCCCCCC	18.85	25777480
1529	Phosphorylation	PAAATAGYGCPLLSD HHHHCCCCCCCCCCC	17.06	25777480
1535	Phosphorylation	GYGCPLLSDLTLSPV CCCCCCCCCCCCCCC	37.95	25777480
1538	Phosphorylation	CPLLSDLTLSPVPRD CCCCCCCCCCCCCHH	30.13	25777480
1540	Phosphorylation	LLSDLTLSPVPRDSL CCCCCCCCCCCHHHC	20.72	26824392
1590	Phosphorylation	PHPEDTFTVTSL--- CCCCCCCEEECC---	25.60	26643407
1592	Phosphorylation	PEDTFTVTSL----- CCCCCEEECC-----	22.66	26643407
1593	Phosphorylation	EDTFTVTSL------ CCCCEEECC------	27.96	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AHDC1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AHDC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AHDC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of AHDC1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AHDC1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-825, AND MASSSPECTROMETRY.	17525332 [Abstract]