TDIF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TDIF2_MOUSE
• UniProt AC: Q8R2M2
• Protein Name: Deoxynucleotidyltransferase terminal-interacting protein 2
• Gene Name: Dnttip2
• Organism: Mus musculus (Mouse).
• Sequence Length: 758
• Subcellular Localization: Nucleus.
• Protein Description: Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (By similarity)..
• Protein Sequence: MVVTRSGLSRTRLQESSQQKRSAPRRIGTHLESTKESGSDGSTAESQPAEKQHSRSSSRTTGPAEIIVLISDDEASETESHTSGVTSVLEDQEPIVRVTRKRQIVIASTSKSTVRKRQKVAPQHASADEVVVSEAESHVSGVSMVVPSTERSSRNKANSQRDSSQESQSGTVSDAELSCSGISSLEILPRTTARNVKKKLQFPAEKNDTKITPGNKKQIVGMSVCSEDSDATQLSARPLSQRNMPNVSDSETYNSDFDDSSPRNSGKKLTAQNHQNLHIQEEKRANVVSLTEVRKENCKSLDEEDLKITEEKVINEKDSQRSLSEAQDTSLQQSVSQNHSSTPNKKPTFQLSSPDRKALMKSLEHKFAVVNVERWNDKRGGSGKKSDLAQLGGGGGGGDDNEPTGAGISDDKSSQSGVPLECDTKPCKSELSMTQDTTDSPVLLFLSSDESQQSDSSENERDTLCSVENNGQKEASAEDLEDAACDSALFVIDKTPGLSADKNFYLEDKAPSEVAIEEEKEEEEKEEENSEEDSSDSDENKDESSDEEDLLSNTKSKLLKLTSSSIDPGLNIKQLGGLYINFNVDKLQPHKETLTQIKEKKKNELLQKAVITPDFEKKHCVPPYSESKHRLQKQRRKERQKTAGNGWFGMKAPELTDELKNDLRALKMRAGMDPKRFYKKNDRDGFPKYFQVGTIVDNPADFYHSRIPKKQRKKTIVEELLADSEFRRFNRRKYSEIMAEKAANAEGKKFKKKKKFRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	RTRLQESSQQKRSAP HHHHHHHHHHHHHCC	35.56	-
29	Phosphorylation	SAPRRIGTHLESTKE HCCHHHHHHHHHCCC	22.40	21743459
33	Phosphorylation	RIGTHLESTKESGSD HHHHHHHHCCCCCCC	51.65	25159016
34	Phosphorylation	IGTHLESTKESGSDG HHHHHHHCCCCCCCC	29.47	21743459
37	Phosphorylation	HLESTKESGSDGSTA HHHHCCCCCCCCCCC	45.19	25159016
39	Phosphorylation	ESTKESGSDGSTAES HHCCCCCCCCCCCCC	48.34	26824392
42	Phosphorylation	KESGSDGSTAESQPA CCCCCCCCCCCCCCC	29.45	28507225
43	Phosphorylation	ESGSDGSTAESQPAE CCCCCCCCCCCCCCC	39.72	21659605
46	Phosphorylation	SDGSTAESQPAEKQH CCCCCCCCCCCCHHH	38.71	25159016
71	Phosphorylation	AEIIVLISDDEASET EEEEEEEECCCCCCC	34.54	30635358
76	Phosphorylation	LISDDEASETESHTS EEECCCCCCCCCCCC	42.90	30635358
78	Phosphorylation	SDDEASETESHTSGV ECCCCCCCCCCCCCC	40.05	30635358
80	Phosphorylation	DEASETESHTSGVTS CCCCCCCCCCCCCCH	39.21	30635358
82	Phosphorylation	ASETESHTSGVTSVL CCCCCCCCCCCCHHH	36.13	30635358
83	Phosphorylation	SETESHTSGVTSVLE CCCCCCCCCCCHHHC	26.33	30635358
86	Phosphorylation	ESHTSGVTSVLEDQE CCCCCCCCHHHCCCC	19.35	30635358
87	Phosphorylation	SHTSGVTSVLEDQEP CCCCCCCHHHCCCCC	23.46	30635358
108	Phosphorylation	KRQIVIASTSKSTVR CCEEEEEECCHHHHH	23.30	26824392
109	Phosphorylation	RQIVIASTSKSTVRK CEEEEEECCHHHHHH	31.02	29895711
110	Phosphorylation	QIVIASTSKSTVRKR EEEEEECCHHHHHHH	23.32	29895711
113	Phosphorylation	IASTSKSTVRKRQKV EEECCHHHHHHHCCC	28.24	29514104
126	Phosphorylation	KVAPQHASADEVVVS CCCCCCCCCCEEEEE	33.84	25159016
133	Phosphorylation	SADEVVVSEAESHVS CCCEEEEEHHHHHCC	21.34	28507225
137	Phosphorylation	VVVSEAESHVSGVSM EEEEHHHHHCCCEEE	35.92	25159016
140	Phosphorylation	SEAESHVSGVSMVVP EHHHHHCCCEEEEEE	28.22	21659605
143	Phosphorylation	ESHVSGVSMVVPSTE HHHCCCEEEEEECCC	14.91	25159016
148	Phosphorylation	GVSMVVPSTERSSRN CEEEEEECCCCHHCC	31.15	26643407
149	Phosphorylation	VSMVVPSTERSSRNK EEEEEECCCCHHCCC	29.37	26643407
163	Phosphorylation	KANSQRDSSQESQSG CCCCCCCCCCCCCCC	35.79	25619855
164	Phosphorylation	ANSQRDSSQESQSGT CCCCCCCCCCCCCCC	42.11	25619855
167	Phosphorylation	QRDSSQESQSGTVSD CCCCCCCCCCCCCCH	23.24	25619855
169	Phosphorylation	DSSQESQSGTVSDAE CCCCCCCCCCCCHHH	45.79	25619855
171	Phosphorylation	SQESQSGTVSDAELS CCCCCCCCCCHHHHC	23.29	27087446
173	Phosphorylation	ESQSGTVSDAELSCS CCCCCCCCHHHHCCC	30.82	27087446
178	Phosphorylation	TVSDAELSCSGISSL CCCHHHHCCCCCCCE	9.57	25619855
180	Phosphorylation	SDAELSCSGISSLEI CHHHHCCCCCCCEEE	35.47	25619855
183	Phosphorylation	ELSCSGISSLEILPR HHCCCCCCCEEECCC	32.18	25619855
184	Phosphorylation	LSCSGISSLEILPRT HCCCCCCCEEECCCC	28.27	25619855
229	Phosphorylation	MSVCSEDSDATQLSA EEECCCCCCCCHHHC	25.70	-
240	Phosphorylation	QLSARPLSQRNMPNV HHHCCCHHHCCCCCC	29.76	-
248	Phosphorylation	QRNMPNVSDSETYNS HCCCCCCCCCHHCCC	41.90	25521595
250	Phosphorylation	NMPNVSDSETYNSDF CCCCCCCCHHCCCCC	25.08	27087446
252	Phosphorylation	PNVSDSETYNSDFDD CCCCCCHHCCCCCCC	31.77	27087446
253	Phosphorylation	NVSDSETYNSDFDDS CCCCCHHCCCCCCCC	14.49	27087446
255	Phosphorylation	SDSETYNSDFDDSSP CCCHHCCCCCCCCCC	29.28	25521595
260	Phosphorylation	YNSDFDDSSPRNSGK CCCCCCCCCCCCCCC	44.05	22942356
261	Phosphorylation	NSDFDDSSPRNSGKK CCCCCCCCCCCCCCC	34.57	27087446
265	Phosphorylation	DDSSPRNSGKKLTAQ CCCCCCCCCCCCCHH	53.95	23984901
300	Phosphorylation	VRKENCKSLDEEDLK HHHHHHCCCCHHHHH	43.16	25159016
319	Phosphorylation	KVINEKDSQRSLSEA HHHCHHHHHCCHHHH	38.26	25338131
322	Phosphorylation	NEKDSQRSLSEAQDT CHHHHHCCHHHHHHH	28.72	25159016
324	Phosphorylation	KDSQRSLSEAQDTSL HHHHCCHHHHHHHHH	31.94	25159016
329	Phosphorylation	SLSEAQDTSLQQSVS CHHHHHHHHHHHHHH	21.18	25159016
330	Phosphorylation	LSEAQDTSLQQSVSQ HHHHHHHHHHHHHHC	32.25	25159016
334	Phosphorylation	QDTSLQQSVSQNHSS HHHHHHHHHHCCCCC	15.69	25159016
336	Phosphorylation	TSLQQSVSQNHSSTP HHHHHHHHCCCCCCC	30.43	25159016
340	Phosphorylation	QSVSQNHSSTPNKKP HHHHCCCCCCCCCCC	43.38	25159016
341	Phosphorylation	SVSQNHSSTPNKKPT HHHCCCCCCCCCCCC	40.09	25159016
342	Phosphorylation	VSQNHSSTPNKKPTF HHCCCCCCCCCCCCE	33.62	25159016
348	Phosphorylation	STPNKKPTFQLSSPD CCCCCCCCEECCCHH	32.66	25159016
352	Phosphorylation	KKPTFQLSSPDRKAL CCCCEECCCHHHHHH	29.10	28973931
353	Phosphorylation	KPTFQLSSPDRKALM CCCEECCCHHHHHHH	39.14	26824392
409	Phosphorylation	EPTGAGISDDKSSQS CCCCCCCCCCCCCCC	38.55	30482847
414	Phosphorylation	GISDDKSSQSGVPLE CCCCCCCCCCCCCCE	33.82	28973931
448	Phosphorylation	PVLLFLSSDESQQSD CEEEEECCCHHHCCC	47.77	24224561
451	Phosphorylation	LFLSSDESQQSDSSE EEECCCHHHCCCCCC	38.21	24224561
466	Phosphorylation	NERDTLCSVENNGQK CHHHCCCEECCCCCC	35.26	25521595
476	Phosphorylation	NNGQKEASAEDLEDA CCCCCCCCHHHHHHH	33.03	27087446
487	Phosphorylation	LEDAACDSALFVIDK HHHHHCCEEEEEEEC	27.10	25159016
495	Phosphorylation	ALFVIDKTPGLSADK EEEEEECCCCCCCCC	20.88	28066266
499	Phosphorylation	IDKTPGLSADKNFYL EECCCCCCCCCCEEC	40.09	28066266
505	Phosphorylation	LSADKNFYLEDKAPS CCCCCCEECCCCCCC	20.69	23984901
512	Phosphorylation	YLEDKAPSEVAIEEE ECCCCCCCCCCCHHH	49.95	25521595
544	Phosphorylation	SDENKDESSDEEDLL CCCCCCCCCCHHHHH	53.90	25521595
545	Phosphorylation	DENKDESSDEEDLLS CCCCCCCCCHHHHHH	47.17	25521595
565	Phosphorylation	LLKLTSSSIDPGLNI HHHHHHCCCCCCCCH	30.67	29514104
612	Phosphorylation	LLQKAVITPDFEKKH HHHHHCCCCCHHHHC	15.37	26824392
689	Phosphorylation	DRDGFPKYFQVGTIV CCCCCCCEEEEEEEE	10.24	27180971
694	Phosphorylation	PKYFQVGTIVDNPAD CCEEEEEEEECCHHH	20.97	27180971
715	Phosphorylation	PKKQRKKTIVEELLA CHHHHCHHHHHHHHC	33.03	27600695
735	Phosphorylation	RFNRRKYSEIMAEKA HHHHHHHHHHHHHHH	24.55	27600695

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TDIF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TDIF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TDIF2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TDIF2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544 AND SER-545, ANDMASS SPECTROMETRY.
PubMed: 19367708