| UniProt ID | DPY30_MOUSE | |
|---|---|---|
| UniProt AC | Q99LT0 | |
| Protein Name | Protein dpy-30 homolog | |
| Gene Name | Dpy30 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 99 | |
| Subcellular Localization | Nucleus . Golgi apparatus, trans-Golgi network. Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4'. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs. | |
| Protein Description | As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play an indirect or direct role in endosomal transport.. | |
| Protein Sequence | MESEQMLEGQTQVAENPHSEYGLTDSVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MESEQMLE -------CCHHHHHC | 13.27 | - | |
| 3 | Phosphorylation | -----MESEQMLEGQ -----CCHHHHHCCC | 31.65 | 26239621 | |
| 11 | Phosphorylation | EQMLEGQTQVAENPH HHHHCCCCCCCCCCC | 35.55 | 26643407 | |
| 19 | Phosphorylation | QVAENPHSEYGLTDS CCCCCCCCCCCCCHH | 33.50 | 21149613 | |
| 21 | Phosphorylation | AENPHSEYGLTDSVE CCCCCCCCCCCHHHH | 22.05 | 25293948 | |
| 24 | Phosphorylation | PHSEYGLTDSVERIV CCCCCCCCHHHHHHH | 23.12 | 21149613 | |
| 26 | Phosphorylation | SEYGLTDSVERIVEN CCCCCCHHHHHHHHH | 22.20 | 26239621 | |
| 35 | Acetylation | ERIVENEKINAEKSS HHHHHHCCCCCCHHC | 53.49 | - | |
| 35 | Ubiquitination | ERIVENEKINAEKSS HHHHHHCCCCCCHHC | 53.49 | 22790023 | |
| 45 | Ubiquitination | AEKSSKQKVDLQSLP CCHHCCCCCCHHHCC | 41.26 | 22790023 | |
| 50 | Phosphorylation | KQKVDLQSLPTRAYL CCCCCHHHCCCHHHC | 43.54 | 21454597 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DPY30_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DPY30_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DPY30_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DPY30_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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