UBP21_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP21_MOUSE
• UniProt AC: Q9QZL6
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 21
• Gene Name: Usp21
• Organism: Mus musculus (Mouse).
• Sequence Length: 566
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization (By similarity)..
• Protein Sequence: MPQASEHRLGRTREPPVNVQPRVGAKIPFPPRARSKERRNPVPGPNSMLRPLPPRPGPPDERLKKLELGRGRTSGSRPRGPLRADHGVPLPGSPPPAVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGAGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLLSIRTEPPTSHGSFHMISARPSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASGPVPSPPRRGGGALHEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSTSRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPLRCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Phosphorylation	HGVPLPGSPPPAVAL CCCCCCCCCCCCEEC	32.09	26824392
111	Phosphorylation	SRTNLARSKSVSSGD CCCCCHHCCCCCCCC	24.55	-
113	Phosphorylation	TNLARSKSVSSGDLR CCCHHCCCCCCCCCC	28.60	26824392
115	Phosphorylation	LARSKSVSSGDLRPM CHHCCCCCCCCCCCC	35.38	26643407
116	Phosphorylation	ARSKSVSSGDLRPMG HHCCCCCCCCCCCCE	33.88	23984901
476	Ubiquitination	TSRGSIKKSSVGVDF CCCCCCCCCCCCCCC	46.42	-
495	Phosphorylation	LSLGDFASDKAGSPV CCHHHHCCCCCCCCH	39.37	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP21_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP21_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP21_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NANOG_MOUSE	Nanog	physical	27886188

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.