DMAP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DMAP1_MOUSE
• UniProt AC: Q9JI44
• Protein Name: DNA methyltransferase 1-associated protein 1
• Gene Name: Dmap1
• Organism: Mus musculus (Mouse).
• Sequence Length: 468
• Subcellular Localization: Nucleus. Cytoplasm. Targeted to replication foci throughout S phase by DNMT1.
• Protein Description: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity (By similarity)..
• Protein Sequence: MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGAPAAAAVGPTPASAEPTVSESGLGLDPTKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATGADVRDI -----CCCCCCHHHH	31.44	29895711
41	Phosphorylation	DKKKSKKSSETLTFK CCCCCCCCCCCEEEE	36.82	28066266
42	Phosphorylation	KKKSKKSSETLTFKR CCCCCCCCCCEEEEC	43.40	28066266
44	Phosphorylation	KSKKSSETLTFKRPE CCCCCCCCEEEECCC	32.80	28066266
415	Phosphorylation	AAAAVGPTPASAEPT CHHHCCCCCCCCCCC	26.09	25777480
418	Phosphorylation	AVGPTPASAEPTVSE HCCCCCCCCCCCCCC	34.08	25777480
422	Phosphorylation	TPASAEPTVSESGLG CCCCCCCCCCCCCCC	28.33	25777480
424	Phosphorylation	ASAEPTVSESGLGLD CCCCCCCCCCCCCCC	28.64	25777480
426	Phosphorylation	AEPTVSESGLGLDPT CCCCCCCCCCCCCCC	31.63	25777480
433	Phosphorylation	SGLGLDPTKDTIIDV CCCCCCCCCCCEEEC	41.02	25777480
436	Phosphorylation	GLDPTKDTIIDVVGA CCCCCCCCEEECCCC	22.76	25777480
446	Phosphorylation	DVVGAPLTPNSRKRR ECCCCCCCCCHHHHH	21.26	25521595
449	Phosphorylation	GAPLTPNSRKRRESA CCCCCCCHHHHHHHC	40.14	22942356
455	Phosphorylation	NSRKRRESASSSSSV CHHHHHHHCCCCHHH	31.47	27087446
457	Phosphorylation	RKRRESASSSSSVKK HHHHHHCCCCHHHHC	39.78	27087446
458	Phosphorylation	KRRESASSSSSVKKA HHHHHCCCCHHHHCC	33.68	27087446
459	Phosphorylation	RRESASSSSSVKKAK HHHHCCCCHHHHCCC	24.92	23375375
460	Phosphorylation	RESASSSSSVKKAKK HHHCCCCHHHHCCCC	40.89	23375375
461	Phosphorylation	ESASSSSSVKKAKKP HHCCCCHHHHCCCCC	39.65	23375375

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DMAP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DMAP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DMAP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNMT1_MOUSE	Dnmt1	physical	21383065

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-446, AND MASSSPECTROMETRY.
PubMed: 15345747