ELYS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELYS_MOUSE
• UniProt AC: Q8CJF7
• Protein Name: Protein ELYS
• Gene Name: Ahctf1
• Organism: Mus musculus (Mouse).
• Sequence Length: 2243
• Subcellular Localization: Chromosome, centromere, kinetochore. Nucleus, nucleoplasm . Nucleus, nuclear pore complex . Nucleus matrix . Cytoplasm . Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears t
• Protein Description: Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis (By similarity). Has also been proposed to function as a transcription factor which may play a specific role in hematopoietic tissues. [PubMed: 11952839]
• Protein Sequence: MQDLTAQVTSDLLHFPEVTIEALGEDEITLESVLRGKFAAGKNGLACLACGPQLEVVNSLTGERLSAYRFSGVNEQPPVVLAVKEFSWHKRTGLLIGLEEADGSVLCLYDLGISRVVKAVVLPGRVTAIEPIINHGGASASTQHLHPSLRWLFGVAAVVTDVGQILLIDLCLDDLSCSQNEVEASDLEVITGIPAEVPHIRERVMREGRHLCFQLVSPLGVAISTLSYINRTNQLAVGFSDGYLALWNMKSMKREYYTQLEGGRVPVHAVAFQEPENDPRNCCYLWAVQSTQDSEGDVLSLHLLQLAFGDRKCLASGQILYEGLEYCEERYTLDLAGGTFPLRGQTSNTKLLGCQSIERFPSHGDREESMREALSPDTSVSVFTWQVNIYGQGKPSVYLGLFDINRWYHAQMPDSLRSGESLHNCSYFALWSLDSVVSRTSPHHILDILVHERSLNRGVPPSYPPPEQFFNPSTFNFDATCLLDSGVIHVTCAGFQKETLTFLKKSGPTLNEVIPDSYNRCLVAGLLSPRLIDIQPSSLSQEEQLEAILSAAIQTSSLGLLTGYIRTWIIEEQPNSAANLRFVLEWTWNKVVLTKEEFDRLCVPLFDGSCRFIDPQTIQSIQQCHLLLSNLSTVLSCFAMEAQGITERGLVDLSNKHMVTQLLCQYAHMVLWFCHSGLLPEGLDDALQLSRLRYNYPVIQNYYTSRRQKSERSPRGKWNHDCLMIDGLVSQLGDEVEKLWKRDEGGTGRYPPASIHALLDIYLLDNITEASKHAITIYLLLDIMYSFPNKTDTPIESFPTAFAISWGQVKLVQGFWLLDHNDYENGLDLLFHPVTAKPASWQHSKIIEAFMSQGEHKQALRYLQTMKPTVSSSNEVILHLTVLLFNRCMVEAWNLLRQNSNRVNIEELLKHAYEVCQEMGLMEDLLKLPFTNTEQECLVKFLQSSTSVENHEFLLVHHLQRANYISALKLNQILKNNLMSDRDPRLRERSVTRNSILDQYGKILPRVQRKLAVERAKPYHLSTSSVFHEVSRPKPLSAFPKKAITGTVLTRSTFISNVLSKIGEVWASHEPRNGVSLFNSPKTEQPSPVVHSFPHPELPEAFVGTPISNTSQRISRLLDLVVHPVPQPSQCLEFIQQSPTRSPLCLLSSSLPLSSQFKRPHQNTSRPSELLLLETPLIVKKAKSLALSATSSGFAEFTPPSILRSGFRTTPLASPSLSPGRSLTPPFRVKETRISFMEEGMNTHWTDRATDDRNTKAFVSTSFHKCGLPAETEWMKTSDKNTYFPLDVPAKGPQKVVAESLATHSGRLEKLDVSKEDSTASTRSDQTSLEYHDAPSPEDLEGAVFVSPKPASSSTELTTNSTLQTERDNDKDAFKSEGAPSPVKKQIGTGDAAVEAFSELSRLDPVERAEASFAVSSVCEGETSTSNSKTSVLDGIVPIESRTSILTADHKESVANTVADVESSGSTSSKCPVTSERSLGQKLTLNLKEDEIEAHVPKENVGLPEESPRISAAPSDTHEIHLIGCENLEVQNSEEEAKNLSFDELYPLGAEKLEYNLSTIEQQFCDLPDDKDSAECDAAEVDGELFVAQSNFTLILEGEEGEAEASDSAAPNMLPKATKEKPVCHREPHNQERVTDLPSAVTADQESHKVETLPYVPEPVKVAIAENLLDVIKDTRSKEATPVAAGEAGDEDGAVIVSKAAHSSRLTNSTPKTVKEPHAETVNTSQNDDMVSSRTLTRRQHALSLNVTSEQEPSAVATPKKRTRKIKETPESSERTCSDLKVAPENQLTAQSPPAPRRGKKKDVSQGTLPSSGAVEPEPEPQGTPGRLRLRTQPPEPAAEETPSRTKVRLSSVRKGTPRRLKKSVENGQSTEILDDLKGSEAASHDGTVTELRNANLEDTQNMEYKQDEHSDQQLPLKRKRVREREVSVSSVTEEPKLDSSQLPLQTGLDVPATPRKRGRPRKVVPLEADGGTTGKEQTSPQKKDVPVVRRSTRNTPARNVSTLEKSVLVPNKEAALVVTSKRRPTKKSAEESSKDPSAAVSDLAGGAAHTESADRRDGLLAAAALTPSAQGTRTRSRRTMLLTDISEPKTEPLFPPPSVKVPKKKSKAENMEAAAQLKELVSDLSSQFVVSPPALRTRQKSISNTSKLLGELESDPKPLEIIEQKPKRSRTVKTRASRNTGKGSSWSPPPVEIKLVSPLASPVDEIKTGKPRKTAEIAGKTLGRGRKKPSSFPKQILRRKML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
518	Phosphorylation	NEVIPDSYNRCLVAG HHHCCCCCHHHHHHH	17.63	-
528	Phosphorylation	CLVAGLLSPRLIDIQ HHHHHHCCCEEEECC	17.02	26824392
969	Ubiquitination	ANYISALKLNQILKN HHHHHHHHHHHHHHC	45.14	22790023
995	Phosphorylation	ERSVTRNSILDQYGK HHHHHHHHHHHHHHC	22.65	29176673
1000	Phosphorylation	RNSILDQYGKILPRV HHHHHHHHHCHHHHH	21.76	20139300
1002	Ubiquitination	SILDQYGKILPRVQR HHHHHHHCHHHHHHH	35.81	22790023
1052	Phosphorylation	TGTVLTRSTFISNVL CCCCCCHHHHHHHHH	23.57	22006019
1053	Phosphorylation	GTVLTRSTFISNVLS CCCCCHHHHHHHHHH	23.00	29233185
1068	Phosphorylation	KIGEVWASHEPRNGV HHHHHHHCCCCCCCC	16.81	27841257
1076	Phosphorylation	HEPRNGVSLFNSPKT CCCCCCCCCCCCCCC	28.74	21659605
1080	Phosphorylation	NGVSLFNSPKTEQPS CCCCCCCCCCCCCCC	22.05	25521595
1083	Phosphorylation	SLFNSPKTEQPSPVV CCCCCCCCCCCCCCE	43.14	25619855
1087	Phosphorylation	SPKTEQPSPVVHSFP CCCCCCCCCCEECCC	29.98	23984901
1092	Phosphorylation	QPSPVVHSFPHPELP CCCCCEECCCCCCCC	28.94	26824392
1105	Phosphorylation	LPEAFVGTPISNTSQ CCHHHCCCCCCCHHH	16.49	25619855
1110	Phosphorylation	VGTPISNTSQRISRL CCCCCCCHHHHHHHH	21.32	25619855
1111	Phosphorylation	GTPISNTSQRISRLL CCCCCCHHHHHHHHH	23.01	25619855
1129	Phosphorylation	VHPVPQPSQCLEFIQ HCCCCCHHHHHHHHH	28.42	25619855
1138	Phosphorylation	CLEFIQQSPTRSPLC HHHHHHCCCCCCCCH	16.32	27087446
1140	Phosphorylation	EFIQQSPTRSPLCLL HHHHCCCCCCCCHHH	49.37	25619855
1142	Phosphorylation	IQQSPTRSPLCLLSS HHCCCCCCCCHHHHC	25.38	26239621
1148	Phosphorylation	RSPLCLLSSSLPLSS CCCCHHHHCCCCCCC	12.63	26060331
1149	Phosphorylation	SPLCLLSSSLPLSSQ CCCHHHHCCCCCCCC	35.54	26060331
1150	Phosphorylation	PLCLLSSSLPLSSQF CCHHHHCCCCCCCCC	30.54	26060331
1155	Phosphorylation	SSSLPLSSQFKRPHQ HCCCCCCCCCCCCCC	47.52	-
1175	Phosphorylation	SELLLLETPLIVKKA HHHEEECCCHHHHHH	24.30	28066266
1190	Phosphorylation	KSLALSATSSGFAEF HHHHHHCCCCCCCCC	21.76	22006019
1205	Phosphorylation	TPPSILRSGFRTTPL CCHHHHCCCCCCCCC	38.55	26239621
1209	Phosphorylation	ILRSGFRTTPLASPS HHCCCCCCCCCCCCC	30.42	27087446
1210	Phosphorylation	LRSGFRTTPLASPSL HCCCCCCCCCCCCCC	16.43	21082442
1214	Phosphorylation	FRTTPLASPSLSPGR CCCCCCCCCCCCCCC	23.78	25521595
1216	Phosphorylation	TTPLASPSLSPGRSL CCCCCCCCCCCCCCC	38.70	26824392
1218	Phosphorylation	PLASPSLSPGRSLTP CCCCCCCCCCCCCCC	29.64	27087446
1222	Phosphorylation	PSLSPGRSLTPPFRV CCCCCCCCCCCCCCC	42.37	23984901
1224	Phosphorylation	LSPGRSLTPPFRVKE CCCCCCCCCCCCCEE	30.11	22942356
1235	Phosphorylation	RVKETRISFMEEGMN CCEECEEEHHHCCCC	18.43	26370283
1260	Phosphorylation	RNTKAFVSTSFHKCG CCCCEEEECCHHHCC	16.33	29176673
1261	Phosphorylation	NTKAFVSTSFHKCGL CCCEEEECCHHHCCC	30.06	27600695
1262	Phosphorylation	TKAFVSTSFHKCGLP CCEEEECCHHHCCCC	20.18	26745281
1300	Phosphorylation	PQKVVAESLATHSGR CCCHHHHHHHHCCCC	17.36	28066266
1303	Phosphorylation	VVAESLATHSGRLEK HHHHHHHHCCCCEEE	23.13	28066266
1305	Phosphorylation	AESLATHSGRLEKLD HHHHHHCCCCEEECC	22.66	28066266
1314	Phosphorylation	RLEKLDVSKEDSTAS CEEECCCCCCCCCCC	29.96	28066266
1324	Phosphorylation	DSTASTRSDQTSLEY CCCCCCCCCCCCEEE	33.87	28066266
1327	Phosphorylation	ASTRSDQTSLEYHDA CCCCCCCCCEEECCC	40.02	28066266
1328	Phosphorylation	STRSDQTSLEYHDAP CCCCCCCCEEECCCC	17.36	28066266
1331	Phosphorylation	SDQTSLEYHDAPSPE CCCCCEEECCCCCHH	15.42	28066266
1336	Phosphorylation	LEYHDAPSPEDLEGA EEECCCCCHHHCCCC	42.51	21149613
1347	Phosphorylation	LEGAVFVSPKPASSS CCCCEEEECCCCCCC	18.75	29550500
1376	Phosphorylation	NDKDAFKSEGAPSPV CCHHHHHCCCCCCCC	34.51	29472430
1381	Phosphorylation	FKSEGAPSPVKKQIG HHCCCCCCCCHHCCC	41.62	25521595
1430	Phosphorylation	TSTSNSKTSVLDGIV CCCCCCCCEEEEEEE	24.72	22871156
1431	Phosphorylation	STSNSKTSVLDGIVP CCCCCCCEEEEEEEE	25.15	22871156
1441	Phosphorylation	DGIVPIESRTSILTA EEEEECCCCCCEEEC	41.39	27600695
1443	Phosphorylation	IVPIESRTSILTADH EEECCCCCCEEECCC	29.42	27600695
1444	Phosphorylation	VPIESRTSILTADHK EECCCCCCEEECCCH	17.94	27600695
1447	Phosphorylation	ESRTSILTADHKESV CCCCCEEECCCHHHH	28.50	22871156
1457	Phosphorylation	HKESVANTVADVESS CHHHHHHHEEHHHCC	13.82	22871156
1463	Phosphorylation	NTVADVESSGSTSSK HHEEHHHCCCCCCCC	39.59	19060867
1464	Phosphorylation	TVADVESSGSTSSKC HEEHHHCCCCCCCCC	24.21	25293948
1466	Phosphorylation	ADVESSGSTSSKCPV EHHHCCCCCCCCCCC	27.36	25293948
1467	Phosphorylation	DVESSGSTSSKCPVT HHHCCCCCCCCCCCC	40.31	25293948
1468	Phosphorylation	VESSGSTSSKCPVTS HHCCCCCCCCCCCCC	29.51	19060867
1469	Phosphorylation	ESSGSTSSKCPVTSE HCCCCCCCCCCCCCC	38.06	25293948
1474	Phosphorylation	TSSKCPVTSERSLGQ CCCCCCCCCCCCCCC	15.26	25293948
1475	Phosphorylation	SSKCPVTSERSLGQK CCCCCCCCCCCCCCE	31.11	25293948
1507	Phosphorylation	NVGLPEESPRISAAP HCCCCCCCCCCCCCC	20.16	27087446
1517	Phosphorylation	ISAAPSDTHEIHLIG CCCCCCCCCEEEEEE	26.25	-
1533	Phosphorylation	ENLEVQNSEEEAKNL ECCEECCCHHHHHCC	29.33	-
1541	Phosphorylation	EEEAKNLSFDELYPL HHHHHCCCHHHHHHC	39.79	26824392
1546	Phosphorylation	NLSFDELYPLGAEKL CCCHHHHHHCCHHHH	8.38	25777480
1677	Phosphorylation	DVIKDTRSKEATPVA HHHHHCCCCCCCCCC	36.62	25619855
1681	Phosphorylation	DTRSKEATPVAAGEA HCCCCCCCCCCCCCC	21.27	25619855
1725	Phosphorylation	HAETVNTSQNDDMVS CCCCCCCCCCCCCHH	23.06	-
1744	Phosphorylation	TRRQHALSLNVTSEQ CHHHHHHHCCCCCCC	20.77	25619855
1754	Phosphorylation	VTSEQEPSAVATPKK CCCCCCCCCCCCCCC	34.32	28066266
1758	Phosphorylation	QEPSAVATPKKRTRK CCCCCCCCCCCCCCC	29.10	25619855
1769	Phosphorylation	RTRKIKETPESSERT CCCCCCCCCCCCCCC	27.62	29514104
1772	Phosphorylation	KIKETPESSERTCSD CCCCCCCCCCCCHHH	38.41	29514104
1789	Phosphorylation	VAPENQLTAQSPPAP ECCHHCCCCCCCCCC	16.94	25619855
1792	Phosphorylation	ENQLTAQSPPAPRRG HHCCCCCCCCCCCCC	30.32	27087446
1824	Phosphorylation	PEPEPQGTPGRLRLR CCCCCCCCCCCEEEE	19.81	25619855
1842	Phosphorylation	PEPAAEETPSRTKVR CCCCCCCCCCCCEEC	20.33	25619855
1844	Phosphorylation	PAAEETPSRTKVRLS CCCCCCCCCCEECHH	61.06	25619855
1851	Phosphorylation	SRTKVRLSSVRKGTP CCCEECHHHHCCCCC	19.07	24719451
1852	Phosphorylation	RTKVRLSSVRKGTPR CCEECHHHHCCCCCC	30.45	26745281
1864	Phosphorylation	TPRRLKKSVENGQST CCCHHHHHHHCCCCC	32.83	-
1870	Phosphorylation	KSVENGQSTEILDDL HHHHCCCCCCHHHHC	29.43	22871156
1871	Phosphorylation	SVENGQSTEILDDLK HHHCCCCCCHHHHCC	21.11	22871156
1880	Phosphorylation	ILDDLKGSEAASHDG HHHHCCCCCHHCCCC	23.60	28066266
1884	Phosphorylation	LKGSEAASHDGTVTE CCCCCHHCCCCCCHH	29.20	26824392
1888	Phosphorylation	EAASHDGTVTELRNA CHHCCCCCCHHHHHC	30.25	28066266
1900	Phosphorylation	RNANLEDTQNMEYKQ HHCCHHHHCCCCCCC	16.68	-
1928	Phosphorylation	RVREREVSVSSVTEE HHHHCCCCCCCCCCC	16.13	25521595
1930	Phosphorylation	REREVSVSSVTEEPK HHCCCCCCCCCCCCC	16.16	25521595
1931	Phosphorylation	EREVSVSSVTEEPKL HCCCCCCCCCCCCCC	30.79	25521595
1933	Phosphorylation	EVSVSSVTEEPKLDS CCCCCCCCCCCCCCC	36.26	23684622
1940	Phosphorylation	TEEPKLDSSQLPLQT CCCCCCCCCCCCCCC	30.35	25619855
1941	Phosphorylation	EEPKLDSSQLPLQTG CCCCCCCCCCCCCCC	35.09	25619855
1947	Phosphorylation	SSQLPLQTGLDVPAT CCCCCCCCCCCCCCC	47.60	25619855
1954	Phosphorylation	TGLDVPATPRKRGRP CCCCCCCCCCCCCCC	19.98	26824392
1973	Phosphorylation	PLEADGGTTGKEQTS EEECCCCCCCCCCCC	37.59	30482847
1974	Phosphorylation	LEADGGTTGKEQTSP EECCCCCCCCCCCCC	49.91	29895711
1979	Phosphorylation	GTTGKEQTSPQKKDV CCCCCCCCCCCCCCC	43.39	29895711
1980	Phosphorylation	TTGKEQTSPQKKDVP CCCCCCCCCCCCCCC	25.65	26824392
2002	Phosphorylation	NTPARNVSTLEKSVL CCCCCCCCCCEEEEE	30.72	27600695
2020	Phosphorylation	KEAALVVTSKRRPTK CCEEEEEECCCCCCC	22.50	28066266
2021	Phosphorylation	EAALVVTSKRRPTKK CEEEEEECCCCCCCC	16.74	28066266
2067	Phosphorylation	LLAAAALTPSAQGTR HHHHHHCCCCCCCCC	15.52	26824392
2069	Phosphorylation	AAAALTPSAQGTRTR HHHHCCCCCCCCCCC	28.17	25619855
2073	Phosphorylation	LTPSAQGTRTRSRRT CCCCCCCCCCCCCCE	19.45	25619855
2080	Phosphorylation	TRTRSRRTMLLTDIS CCCCCCCEEEEECCC	15.85	28066266
2099	Phosphorylation	EPLFPPPSVKVPKKK CCCCCCCCCCCCCCC	40.10	-
2132	Phosphorylation	LSSQFVVSPPALRTR HHHCCCCCCHHHHCH	21.62	23649490
2142	Phosphorylation	ALRTRQKSISNTSKL HHHCHHHHHCCHHHH	23.94	24453211
2181	Phosphorylation	KTRASRNTGKGSSWS CCCCCCCCCCCCCCC	38.88	29109428
2185	Phosphorylation	SRNTGKGSSWSPPPV CCCCCCCCCCCCCCE	31.92	25619855
2186	Phosphorylation	RNTGKGSSWSPPPVE CCCCCCCCCCCCCEE	40.00	25619855
2188	Phosphorylation	TGKGSSWSPPPVEIK CCCCCCCCCCCEEEE	29.49	26824392
2198	Phosphorylation	PVEIKLVSPLASPVD CEEEEEECCCCCCHH	25.32	26824392
2202	Phosphorylation	KLVSPLASPVDEIKT EEECCCCCCHHHHHC	32.89	26824392
2221	Acetylation	KTAEIAGKTLGRGRK CHHHHCCCCCCCCCC	31.39	23806337
2231	Phosphorylation	GRGRKKPSSFPKQIL CCCCCCCCCCHHHHH	54.19	29176673
2232	Phosphorylation	RGRKKPSSFPKQILR CCCCCCCCCHHHHHH	54.84	29176673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1954	T	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELYS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELYS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ELYS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1381, AND MASSSPECTROMETRY.
PubMed: 19144319