dbPTM

RS27_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RS27_MOUSE
UniProt AC	Q6ZWU9
Protein Name	40S ribosomal protein S27
Gene Name	Rps27 {ECO:0000312\|MGI:MGI:1888676}
Organism	Mus musculus (Mouse).
Sequence Length	84
Subcellular Localization
Protein Description	Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity)..
Protein Sequence	MPLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MPLAKDLLHPSP ---CCCHHHHCCCCH	57.50	23806337
5	Succinylation	---MPLAKDLLHPSP ---CCCHHHHCCCCH	57.50	23806337
11	Phosphorylation	AKDLLHPSPEEEKRK HHHHCCCCHHHHHHH	33.91	27087446
16	Ubiquitination	HPSPEEEKRKHKKKR CCCHHHHHHHHHHHH	70.76	22790023
16	Acetylation	HPSPEEEKRKHKKKR CCCHHHHHHHHHHHH	70.76	23806337
27	Phosphorylation	KKKRLVQSPNSYFMD HHHHHHCCCCCCCCC	20.69	26824392
30	Phosphorylation	RLVQSPNSYFMDVKC HHHCCCCCCCCCCCC	24.11	23984901
31	Phosphorylation	LVQSPNSYFMDVKCP HHCCCCCCCCCCCCC	15.01	25521595
77	S-nitrosylation	KARLTEGCSFRRKQH CEECCCCCCCCCCCC	2.57	24926564
77	S-palmitoylation	KARLTEGCSFRRKQH CEECCCCCCCCCCCC	2.57	28526873
78	Phosphorylation	ARLTEGCSFRRKQH- EECCCCCCCCCCCC-	32.42	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RS27_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RS27_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RS27_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RS27_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RS27_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-31, AND MASSSPECTROMETRY.	18034455 [Abstract]