dbPTM

DDX27_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDX27_MOUSE
UniProt AC	Q921N6
Protein Name	Probable ATP-dependent RNA helicase DDX27
Gene Name	Ddx27
Organism	Mus musculus (Mouse).
Sequence Length	760
Subcellular Localization	Nucleus, nucleolus . Chromosome . Associates with 60S and 90S pre-ribosomal particles.
Protein Description	Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA..
Protein Sequence	MLAELGFIRTIGENDEVPVEPESDSGDEEEEGPIVLGRKQKALQKNRSADFNPDFVFTEKEGMYDGSWALADVMSQLKKKRAATTLDEKIEKVRKRRKAEDKEAKSGKVEEKEGQADSDLKGQENPGEDEAGSKDEDSETDYSSEDEEILTKADTLKVKEKKKKKKGQAAGGFFEDASEYDKSLSFQDMNLSRPLLKAITAMGFKQPTPIQKACIPVGLLGKDICACAATGTGKTAAFALPVLERLIYKPRQAAVTRVLVLVPTRELGIQVHSVTKQLAQFCSITTCLAVGGLDVKSQEAALRAAPDILIATPGRLIDHLHNCPSFHLSSIEVLILDEADRMLDEYFEEQMKEIIRMCSHHRQTMLFSATMTDEVKDLASVSLKNPVRIFVNSNTDVAPFLRQEFIRIRPNREGDREAIVAALLMRTFTDHVMLFTQTKKQAHRMHILLGLLGLQVGELHGNLSQTQRLEALRRFKDEQIDILVATDVAARGLDIEGVKTVINFTMPNTVKHYVHRVGRTARAGRAGRSVSLVGEEERKMLKEIVKAAKAPVKARILPQDVILKFRDKIEKLEKDVYAVLQLEAEEKEMQQSEAQIDTAQRLLAKGKETADQEPERSWFQTKEERKKEKIAKALQEFDLALRGKKKRKKFMKDAKKKGEMTAEERSQFEILKAQMFAERLAKRNRRTKRARAMPEDEPTGPAKKQKQQQKSVFDEELTNTSKKALKQYRAGPSFEERKQSGLPRQRRGNFKSKSRYKRKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	AELGFIRTIGENDEV CCCCCEEECCCCCCC	28.63	25619855
23	Phosphorylation	EVPVEPESDSGDEEE CCCCCCCCCCCCCCC	48.03	25521595
25	Phosphorylation	PVEPESDSGDEEEEG CCCCCCCCCCCCCCC	58.38	25521595
45	Acetylation	RKQKALQKNRSADFN HHHHHHHHCCCCCCC	56.00	7714451
48	Phosphorylation	KALQKNRSADFNPDF HHHHHCCCCCCCCCC	41.40	26745281
133	Phosphorylation	PGEDEAGSKDEDSET CCCCCCCCCCCCCCC	43.94	25521595
138	Phosphorylation	AGSKDEDSETDYSSE CCCCCCCCCCCCCCC	40.11	29550500
140	Phosphorylation	SKDEDSETDYSSEDE CCCCCCCCCCCCCHH	44.16	25195567
142	Phosphorylation	DEDSETDYSSEDEEI CCCCCCCCCCCHHHH	22.86	25195567
143	Phosphorylation	EDSETDYSSEDEEIL CCCCCCCCCCHHHHH	30.02	29550500
144	Phosphorylation	DSETDYSSEDEEILT CCCCCCCCCHHHHHH	42.72	25195567
249	Acetylation	VLERLIYKPRQAAVT HHHHHCCCHHHHCCE	27.08	19858685
372	Phosphorylation	MLFSATMTDEVKDLA HHEEEECCHHHHHHH	25.34	28576409
733	Phosphorylation	KQYRAGPSFEERKQS HHHHCCCCHHHHHHC	44.35	28973931

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DDX27_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDX27_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDX27_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DDX27_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDX27_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-25, AND MASSSPECTROMETRY.	17242355 [Abstract]