TPX2_MOUSE - dbPTM
TPX2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPX2_MOUSE
UniProt AC A2APB8
Protein Name Targeting protein for Xklp2
Gene Name Tpx2
Organism Mus musculus (Mouse).
Sequence Length 745
Subcellular Localization Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucl
Protein Description Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation..
Protein Sequence MSQVPTTYSFDAPTDFINFSSLDAEEDTENIDSWFDEKANLENKFLRQRGIGEPFQGKNSLRKAKLQQGFVTPLKAVDNTYHKETEKENLQKQSIPSNDCSSLDAKRAVSGNTPVQPQRRSIRLSAQKDLEQKEKNHVASVEMKAKRCVAPATDCPPQKRMKVSHKKKLEEEEEGSAPATSRKNERETLEKAKGKHTVPGVPPAREKVLKSTEEQEIEKRLRMQQEVVELRRKNEEFKKLALAGPGQPVKKSTSQVTKTVDFHFLTDERIKQHPKNQEEYKEVNFMSELRKHSSTPARGTRGCTIIKPFNLSKGKKRTFDEAASTYVPIAQQVEAFHKRTPNRYHLRNKKDESLLPSKSVNKIARDPQTPILQTKYRTRAVTCKSTAEQEAEELEKLQQYKFKARELDPRIFESGPILPKRAPVKPPTQPVGFDLEIEKRIHERESKKKTEDEQFEFHSRPCPTKILEDVVGVPEKKVIPATVPKSPVFALKNRIRVPIKDEEEEKPVVIKAQPVPHYGVPYKPHIAEARNVEVCPFSFDTRDKERQLQKEKKIKEMQKGEVPKFKALPVPHFDTINLPEKKVKNVTQAEPFSLETDKRGAYKAEMWKHQLEEEQKQQKDAACFKARPNTVIFQEPFVPKKEKKSLAENPSGSLVQEPFQLATERRAKERQELEKKMAEVEAWKLQQLEEVRQQEEEQQKEELARLRKELVHKANPIRKYAAVEVKSSELPLTVPVSPKFSTRFQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
44UbiquitinationEKANLENKFLRQRGI
HHHHHHHHHHHHCCC		36.08-
60PhosphorylationEPFQGKNSLRKAKLQ
CCCCCCHHHHHHHCC		32.7925266776
72PhosphorylationKLQQGFVTPLKAVDN
HCCCCCCCCHHHHCC		22.2026824392
75AcetylationQGFVTPLKAVDNTYH
CCCCCCHHHHCCCCC		47.7923806337
101PhosphorylationSIPSNDCSSLDAKRA
CCCCCCCCCHHHHHH		36.4825266776
102PhosphorylationIPSNDCSSLDAKRAV
CCCCCCCCHHHHHHH		36.2825266776
110PhosphorylationLDAKRAVSGNTPVQP
HHHHHHHCCCCCCCC		25.9124453211
113PhosphorylationKRAVSGNTPVQPQRR
HHHHCCCCCCCCCHH		28.5026824392
121PhosphorylationPVQPQRRSIRLSAQK
CCCCCHHHHHHHHHH		17.7821659605
125PhosphorylationQRRSIRLSAQKDLEQ
CHHHHHHHHHHHHHH		20.8521743459
128AcetylationSIRLSAQKDLEQKEK
HHHHHHHHHHHHHHH		65.0923806337
140PhosphorylationKEKNHVASVEMKAKR
HHHHCCEEHHHHHHH		19.9528066266
188PhosphorylationSRKNERETLEKAKGK
CCHHHHHHHHHHCCC		46.5728507225
291AcetylationNFMSELRKHSSTPAR
HHHHHHHHCCCCCCC		61.5419847687
294PhosphorylationSELRKHSSTPARGTR
HHHHHCCCCCCCCCC		37.82-
307AcetylationTRGCTIIKPFNLSKG
CCCCEEEECCCCCCC		39.4423806337
312PhosphorylationIIKPFNLSKGKKRTF
EEECCCCCCCCCCCH		40.2326745281
326PhosphorylationFDEAASTYVPIAQQV
HHHHHHHHHCHHHHH		11.1823984901
340PhosphorylationVEAFHKRTPNRYHLR
HHHHHHHCCCCCCCC		29.7123984901
353PhosphorylationLRNKKDESLLPSKSV
CCCCCCCCCCCCCCH		45.3928066266
357PhosphorylationKDESLLPSKSVNKIA
CCCCCCCCCCHHHHH		37.2228066266
359PhosphorylationESLLPSKSVNKIARD
CCCCCCCCHHHHHCC		34.9528066266
369PhosphorylationKIARDPQTPILQTKY
HHHCCCCCCCCCCCC		20.0626824392
374PhosphorylationPQTPILQTKYRTRAV
CCCCCCCCCCCCCEE		26.9722817900
375AcetylationQTPILQTKYRTRAVT
CCCCCCCCCCCCEEC		21.5523806337
414PhosphorylationLDPRIFESGPILPKR
CCHHHHCCCCCCCCC		38.8425159016
465AcetylationHSRPCPTKILEDVVG
HCCCCCCHHHHHHCC		30.3622826441
482PhosphorylationEKKVIPATVPKSPVF
CCCEECCCCCCCCCE		31.8025159016
486PhosphorylationIPATVPKSPVFALKN
ECCCCCCCCCEEECC		21.8926824392
523AcetylationPHYGVPYKPHIAEAR
CCCCCCCCCCCCCCC		24.8523806337
645PhosphorylationVPKKEKKSLAENPSG
CCHHHHHCCCCCCCC		43.8326824392
651PhosphorylationKSLAENPSGSLVQEP
HCCCCCCCCCCCCHH		53.2326643407
653PhosphorylationLAENPSGSLVQEPFQ
CCCCCCCCCCCHHHH		29.7025777480
727PhosphorylationYAAVEVKSSELPLTV
EEEEEEECCCCCCEE		33.9325619855
733PhosphorylationKSSELPLTVPVSPKF
ECCCCCCEEECCCCC		22.3325619855
737PhosphorylationLPLTVPVSPKFSTRF
CCCEEECCCCCCCCC		19.1227087446
741PhosphorylationVPVSPKFSTRFQ---
EECCCCCCCCCC---		25.4623984901
742PhosphorylationPVSPKFSTRFQ----
ECCCCCCCCCC----		38.3423984901
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
369TPhosphorylationKinaseMAPK1P63085
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPX2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPX2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IKKA_MOUSEChukphysical
24115035
FBW1A_MOUSEBtrcphysical
24115035
CHD1_HUMANCHD1physical
26496610
ERCC5_HUMANERCC5physical
26496610
GELS_HUMANGSNphysical
26496610
HS71L_HUMANHSPA1Lphysical
26496610
NCBP1_HUMANNCBP1physical
26496610
IKBE_HUMANNFKBIEphysical
26496610
CDK18_HUMANCDK18physical
26496610
CTIP_HUMANRBBP8physical
26496610
RL6_HUMANRPL6physical
26496610
SDC2_HUMANSDC2physical
26496610
SPG7_HUMANSPG7physical
26496610
SPTN1_HUMANSPTAN1physical
26496610
STX3_HUMANSTX3physical
26496610
XRCC1_HUMANXRCC1physical
26496610
VEZF1_HUMANVEZF1physical
26496610
LUZP1_HUMANLUZP1physical
26496610
KAT6A_HUMANKAT6Aphysical
26496610
ARK72_HUMANAKR7A2physical
26496610
CMC1_HUMANSLC25A12physical
26496610
U3IP2_HUMANRRP9physical
26496610
NOLC1_HUMANNOLC1physical
26496610
CDYL_HUMANCDYLphysical
26496610
NCOR1_HUMANNCOR1physical
26496610
HMGX4_HUMANHMGXB4physical
26496610
INADL_HUMANINADLphysical
26496610
ECI2_HUMANECI2physical
26496610
S27A4_HUMANSLC27A4physical
26496610
PAXI1_HUMANPAXIP1physical
26496610
DCNL4_HUMANDCUN1D4physical
26496610
NECT3_HUMANPVRL3physical
26496610
FBXL4_HUMANFBXL4physical
26496610
CKAP2_HUMANCKAP2physical
26496610
RGAP1_HUMANRACGAP1physical
26496610
UBIA1_HUMANUBIAD1physical
26496610
RSF1_HUMANRSF1physical
26496610
PLXA3_HUMANPLXNA3physical
26496610
ZN687_HUMANZNF687physical
26496610
AFAP1_HUMANAFAP1physical
26496610
NSD1_HUMANNSD1physical
26496610
CSN7B_HUMANCOPS7Bphysical
26496610
IPO4_HUMANIPO4physical
26496610
ARP5L_HUMANARPC5Lphysical
26496610
NEXN_HUMANNEXNphysical
26496610
S38AA_HUMANSLC38A10physical
26496610
HACD2_HUMANPTPLBphysical
26496610
BRWD3_HUMANBRWD3physical
26496610
EOGT_HUMANEOGTphysical
26496610
MY18A_HUMANMYO18Aphysical
26496610
CCD61_HUMANCCDC61physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPX2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, AND MASSSPECTROMETRY.

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