NSD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSD1_HUMAN
• UniProt AC: Q96L73
• Protein Name: Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
• Gene Name: NSD1
• Organism: Homo sapiens (Human).
• Sequence Length: 2696
• Subcellular Localization: Nucleus. Chromosome .
• Protein Description: Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context..
• Protein Sequence: MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47 (in isoform 2)	Phosphorylation	-	14.89	-
109	Phosphorylation	KSDSRAQTPIVCTSL CCCCCCCCCEEEEEC	17.63	25954137
114	Phosphorylation	AQTPIVCTSLSPGGP CCCCEEEEECCCCCC	23.08	25954137
115	Phosphorylation	QTPIVCTSLSPGGPT CCCEEEEECCCCCCC	23.02	24719451
117	Phosphorylation	PIVCTSLSPGGPTAL CEEEEECCCCCCCCE	22.67	27050516
122	Phosphorylation	SLSPGGPTALAMKQE ECCCCCCCCEEECCC	37.26	25954137
135	Phosphorylation	QEPSCNNSPELQVKV CCCCCCCCCCCEEEE	13.03	25954137
209	Phosphorylation	GVKVAMGSEQDSTPE CEEEECCCCCCCCCH	20.99	19369195
214	Phosphorylation	MGSEQDSTPESRHGA CCCCCCCCCHHCCCC	39.09	21815630
214 (in isoform 2)	Phosphorylation	-	39.09	-
217	Phosphorylation	EQDSTPESRHGAVKS CCCCCCHHCCCCCCC	30.68	20068231
217 (in isoform 2)	Phosphorylation	-	30.68	-
224	Phosphorylation	SRHGAVKSPFLPLAP HCCCCCCCCCCCCCC	17.81	25159151
233	Phosphorylation	FLPLAPQTETQKNKQ CCCCCCCCHHHHHHH	39.68	21712546
316	Phosphorylation	FCQPKKKSTPLKYEV CCCCCCCCCCCCHHH	44.10	22199227
317	Phosphorylation	CQPKKKSTPLKYEVG CCCCCCCCCCCHHHC	41.33	22199227
320	Sumoylation	KKKSTPLKYEVGDLI CCCCCCCCHHHCCCH	40.34	-
320	Sumoylation	KKKSTPLKYEVGDLI CCCCCCCCHHHCCCH	40.34	-
321	Phosphorylation	KKSTPLKYEVGDLIW CCCCCCCHHHCCCHH	24.43	21406692
343	Phosphorylation	WWPCRICSDPLINTH CCCCEECCCCCCCCC	39.63	-
416	Ubiquitination	YRHKVPQKILSKWEA CCCCCCHHHHHHHHH	39.27	-
419	Phosphorylation	KVPQKILSKWEASVG CCCHHHHHHHHHHHC	38.91	26270265
424	Phosphorylation	ILSKWEASVGLAEQY HHHHHHHHHCHHHHC	12.76	26270265
431	Phosphorylation	SVGLAEQYDVPKGSK HHCHHHHCCCCCCCC	15.48	28111955
437	Phosphorylation	QYDVPKGSKNRKCIP HCCCCCCCCCCCCCC	32.65	28111955
451	Phosphorylation	PGSIKLDSEEDMPFE CCCEECCCCCCCCCC	54.01	25159151
461	Phosphorylation	DMPFEDCTNDPESEH CCCCCCCCCCCHHHH	55.78	28102081
466	Phosphorylation	DCTNDPESEHDLLLN CCCCCCHHHHHHHHH	45.69	28102081
478	Phosphorylation	LLNGCLKSLAFDSEH HHHHHHHHHHHCCCC	16.39	23403867
483	Phosphorylation	LKSLAFDSEHSADEK HHHHHHCCCCCCCCC	30.65	29255136
486	Phosphorylation	LAFDSEHSADEKEKP HHHCCCCCCCCCCCC	33.11	29255136
501	Methylation	CAKSRARKSSDNPKR CHHHHHHHCCCCCCC	54.01	116253501
511 (in isoform 2)	Phosphorylation	-	8.00	-
528	Ubiquitination	HKDERRGKIPENLGL CCCHHCCCCCCCCCC	53.96	-
539	Phosphorylation	NLGLNFISGDISDTQ CCCCCCCCCCCCCHH	26.69	25332170
543	Phosphorylation	NFISGDISDTQASNE CCCCCCCCCHHHHHH	39.07	25332170
545	Phosphorylation	ISGDISDTQASNELS CCCCCCCHHHHHHHH	21.17	28348404
548	Phosphorylation	DISDTQASNELSRIA CCCCHHHHHHHHHHH	22.48	28102081
559	Phosphorylation	SRIANSLTGSNTAPG HHHHHHCCCCCCCCC	38.08	26074081
561	Phosphorylation	IANSLTGSNTAPGSF HHHHCCCCCCCCCCE	26.27	26074081
563	Phosphorylation	NSLTGSNTAPGSFLF HHCCCCCCCCCCEEE	35.61	26074081
567	Phosphorylation	GSNTAPGSFLFSSCG CCCCCCCCEEECCCC	20.09	26074081
571	Phosphorylation	APGSFLFSSCGKNTA CCCCEEECCCCCCCC	27.19	26074081
572	Phosphorylation	PGSFLFSSCGKNTAK CCCEEECCCCCCCCC	21.39	27050516
580	Ubiquitination	CGKNTAKKEFETSNG CCCCCCCCEEECCCC	66.23	-
589	Phosphorylation	FETSNGDSLLGLPEG EECCCCCCCCCCCCC	27.22	21712546
596 (in isoform 2)	Ubiquitination	-	24.60	21890473
601	Ubiquitination	PEGALISKCSREKNK CCCHHHHHHHCCCCC	29.27	-
606	Acetylation	ISKCSREKNKPQRSL HHHHHCCCCCCCCEE	69.98	12439361
617 (in isoform 2)	Ubiquitination	-	29.20	21890473
640	Phosphorylation	SDSISICTTSDDGSS CCCEEEEEECCCCCC	27.88	30576142
641	Phosphorylation	DSISICTTSDDGSSD CCEEEEEECCCCCCC	26.25	30576142
692 (in isoform 2)	Phosphorylation	-	33.42	-
693 (in isoform 2)	Phosphorylation	-	22.59	-
726	Phosphorylation	AEPGTETSQVNLSDL CCCCCCCCCCCHHHH	26.37	-
734	Ubiquitination	QVNLSDLKASTLVHK CCCHHHHHHHHCEEC	45.33	-
747	Phosphorylation	HKPQSDFTNDALSPK ECCCCCCCCCCCCCC	36.86	23186163
752	Phosphorylation	DFTNDALSPKFNLSS CCCCCCCCCCCCCCC	27.97	24732914
755 (in isoform 2)	Phosphorylation	-	14.62	-
758	Phosphorylation	LSPKFNLSSSISSEN CCCCCCCCCCCCCCC	24.12	20068231
758 (in isoform 2)	Phosphorylation	-	24.12	-
759	Phosphorylation	SPKFNLSSSISSENS CCCCCCCCCCCCCCC	34.55	25072903
760	Phosphorylation	PKFNLSSSISSENSL CCCCCCCCCCCCCCC	24.10	25159151
762	Phosphorylation	FNLSSSISSENSLIK CCCCCCCCCCCCCCC	33.28	25072903
762 (in isoform 3)	Ubiquitination	-	33.28	21890473
763	Phosphorylation	NLSSSISSENSLIKG CCCCCCCCCCCCCCC	38.84	25072903
766	Phosphorylation	SSISSENSLIKGGAA CCCCCCCCCCCCCHH	27.67	23663014
780	Phosphorylation	ANQALLHSKSKQPKF HHHHHHHCCCCCCCC	38.30	20068231
783 (in isoform 3)	Ubiquitination	-	74.49	21890473
811	Phosphorylation	PVINEECSLKCCSSD CCCCCCCCEEECCCC	33.86	27251275
816	Phosphorylation	ECSLKCCSSDTKGSP CCCEEECCCCCCCCC	40.49	23312004
817	Phosphorylation	CSLKCCSSDTKGSPL CCEEECCCCCCCCCC	35.07	30576142
819	Phosphorylation	LKCCSSDTKGSPLAS EEECCCCCCCCCCHH	38.97	30576142
822	Phosphorylation	CSSDTKGSPLASISK CCCCCCCCCCHHHCC	20.49	25159151
826	Phosphorylation	TKGSPLASISKSGKV CCCCCCHHHCCCCCC	34.77	27251275
837	Sumoylation	SGKVDGLKLLNNMHE CCCCCHHHHHHHHHH	57.36	-
837	Sumoylation	SGKVDGLKLLNNMHE CCCCCHHHHHHHHHH	57.36	-
837	Ubiquitination	SGKVDGLKLLNNMHE CCCCCHHHHHHHHHH	57.36	-
849	Phosphorylation	MHEKTRDSSDIETAV HHHHHCCCHHHHHHH	26.98	-
850	Phosphorylation	HEKTRDSSDIETAVV HHHHCCCHHHHHHHH	47.07	24247654
854	Phosphorylation	RDSSDIETAVVKHVL CCCHHHHHHHHHHHH	25.70	-
858	Ubiquitination	DIETAVVKHVLSELK HHHHHHHHHHHHHHH	22.77	-
862	Phosphorylation	AVVKHVLSELKELSY HHHHHHHHHHHHCCH	39.53	24247654
865	Ubiquitination	KHVLSELKELSYRSL HHHHHHHHHCCHHHC	53.19	21890473
865 (in isoform 1)	Ubiquitination	-	53.19	21890473
885	Phosphorylation	DSGTSKPSKPLLFSS CCCCCCCCCCCEEEC	51.12	24719451
886	Acetylation	SGTSKPSKPLLFSSA CCCCCCCCCCEEECC	48.49	26051181
886	Ubiquitination	SGTSKPSKPLLFSSA CCCCCCCCCCEEECC	48.49	21890473
886 (in isoform 1)	Ubiquitination	-	48.49	21890473
906	Sumoylation	IPIEPDYKFSTLLMM CCCCCCCHHHHHHHH	39.97	28112733
909	Phosphorylation	EPDYKFSTLLMMLKD CCCCHHHHHHHHHHH	27.35	20860994
929	Phosphorylation	TKEQRLMTAQNLVSY CHHHHHHHHHHHHHC	29.68	26074081
935	Phosphorylation	MTAQNLVSYRSPGRG HHHHHHHHCCCCCCC	20.28	26074081
936	Phosphorylation	TAQNLVSYRSPGRGD HHHHHHHCCCCCCCC	13.97	26074081
938	Phosphorylation	QNLVSYRSPGRGDCS HHHHHCCCCCCCCCC	24.39	25159151
945	Phosphorylation	SPGRGDCSTNSPVGV CCCCCCCCCCCCCEE	35.05	26074081
946	Phosphorylation	PGRGDCSTNSPVGVS CCCCCCCCCCCCEEE	46.15	26074081
948	Phosphorylation	RGDCSTNSPVGVSKV CCCCCCCCCCEEEEE	22.50	25849741
953	Phosphorylation	TNSPVGVSKVLVSGG CCCCCEEEEEEECCC	15.89	26074081
954	Acetylation	NSPVGVSKVLVSGGS CCCCEEEEEEECCCC	36.86	26051181
958	Phosphorylation	GVSKVLVSGGSTHNS EEEEEEECCCCCCCC	33.02	20068231
961	Phosphorylation	KVLVSGGSTHNSEKK EEEECCCCCCCCCCC	29.98	21815630
962	Phosphorylation	VLVSGGSTHNSEKKG EEECCCCCCCCCCCC	28.49	22199227
965	Phosphorylation	SGGSTHNSEKKGDGT CCCCCCCCCCCCCCC	43.09	21815630
972	Phosphorylation	SEKKGDGTQNSANPS CCCCCCCCCCCCCCC	29.35	30266825
975	Phosphorylation	KGDGTQNSANPSPSG CCCCCCCCCCCCCCC	21.43	30266825
979	Phosphorylation	TQNSANPSPSGGDSA CCCCCCCCCCCCCCC	31.35	30266825
981	Phosphorylation	NSANPSPSGGDSALS CCCCCCCCCCCCCCC	60.80	27174698
985	Phosphorylation	PSPSGGDSALSGELS CCCCCCCCCCCHHHH	34.09	27174698
988	Phosphorylation	SGGDSALSGELSASL CCCCCCCCHHHHHCC	29.91	27732954
992	Phosphorylation	SALSGELSASLPGLL CCCCHHHHHCCCCHH	16.12	22210691
994	Phosphorylation	LSGELSASLPGLLSD CCHHHHHCCCCHHCC	31.55	22210691
1017	O-linked_Glycosylation	KSRSDCVTRRNCGRS CCHHHHCCCCCCCCC	30.18	30379171
1024	Phosphorylation	TRRNCGRSKPSSKLR CCCCCCCCCCCHHHH	33.91	20068231
1027	Phosphorylation	NCGRSKPSSKLRDAF CCCCCCCCHHHHHHH	43.79	20068231
1028	Phosphorylation	CGRSKPSSKLRDAFS CCCCCCCHHHHHHHH	44.21	20068231
1035	O-linked_Glycosylation	SKLRDAFSAQMVKNT HHHHHHHHHHHHHHH	21.22	30379171
1042	Phosphorylation	SAQMVKNTVNRKALK HHHHHHHHHCHHHHH	17.28	-
1061	Phosphorylation	RKLNQLPSVTLDAVL HHHHCCCCCCHHHHH	36.00	28555341
1063	Phosphorylation	LNQLPSVTLDAVLQG HHCCCCCCHHHHHCC	24.21	27251275
1069 (in isoform 2)	Phosphorylation	-	45.18	-
1077	Phosphorylation	GDRERGGSLRGGAED CCHHHCCCCCCCCCC	20.09	25159151
1139	Phosphorylation	GKGPELDSVMNSEND CCCCCHHHHHCCCCC	35.57	28102081
1143	Phosphorylation	ELDSVMNSENDELNG CHHHHHCCCCCCCCC	21.49	25159151
1208	Phosphorylation	DEFPEHRTPSASILE CCCCCCCCCCCHHHC	24.41	25159151
1210	Phosphorylation	FPEHRTPSASILEEP CCCCCCCCCHHHCCC	33.75	29978859
1212	Phosphorylation	EHRTPSASILEEPLT CCCCCCCHHHCCCCC	31.85	29978859
1240	Phosphorylation	RLNVCDKSSASIGDM CCCCCCCCCCCCCCC	20.20	25627689
1241	Phosphorylation	LNVCDKSSASIGDME CCCCCCCCCCCCCCC	31.60	27251275
1243	Phosphorylation	VCDKSSASIGDMEKE CCCCCCCCCCCCCCC	29.11	25159151
1255	Phosphorylation	EKEPGIPSLTPQAEL CCCCCCCCCCCCCCC	42.84	29978859
1257	Phosphorylation	EPGIPSLTPQAELPE CCCCCCCCCCCCCCC	20.07	21815630
1269	Phosphorylation	LPEPAVRSEKKRLRK CCCHHHHCHHHHHCC	47.36	25159151
1299	Acetylation	FAPKKKQKKVQEQVH CCCHHHHHHHHHHHH	64.89	18584603
1300	Acetylation	APKKKQKKVQEQVHK CCHHHHHHHHHHHHH	46.81	18584611
1334	Phosphorylation	NKQVDENSLISTKEE CCCCCCCCCCCCCCC	25.65	23401153
1337	Phosphorylation	VDENSLISTKEEPPV CCCCCCCCCCCCCCC	38.43	20068231
1338	Phosphorylation	DENSLISTKEEPPVL CCCCCCCCCCCCCCC	35.17	20068231
1339	Sumoylation	ENSLISTKEEPPVLE CCCCCCCCCCCCCCC	53.97	28112733
1382	Phosphorylation	VPVAPEVSPRPALES ECCCCCCCCCCCCCC	17.33	26074081
1389	Phosphorylation	SPRPALESEELLVKT CCCCCCCCHHEEECC	36.90	26074081
1396	Phosphorylation	SEELLVKTPGNYESK CHHEEECCCCCHHHH	29.02	28985074
1411	Sumoylation	RQRKPTKKLLESNDL CCCCCCHHHHHCCCC	61.86	-
1411	Sumoylation	RQRKPTKKLLESNDL CCCCCCHHHHHCCCC	61.86	-
1446	Phosphorylation	GHLENGITESCATSY CCCCCCCCHHHCCCC	24.20	-
1454	Phosphorylation	ESCATSYSKDFGGGT HHHCCCCCCCCCCCC	26.05	-
1480	Acetylation	RQRHAAAKMQCKKVK HHHHHHHHHHCCCCC	25.44	7665215
1498	Phosphorylation	SSKEIPGSEGELMPH CCCCCCCCCCCCCCC	36.75	28985074
1507	Phosphorylation	GELMPHRTATSPKET CCCCCCCCCCCCHHH	31.11	23401153
1509	Phosphorylation	LMPHRTATSPKETVE CCCCCCCCCCHHHHH	44.97	23401153
1510	Phosphorylation	MPHRTATSPKETVEE CCCCCCCCCHHHHHH	31.35	23927012
1514	Phosphorylation	TATSPKETVEEGVEH CCCCCHHHHHHCCCC	39.07	23927012
1529	Acetylation	DPGMPASKKMQGERG CCCCCHHHHCCCCCC	55.13	25953088
1542	Ubiquitination	RGGGAALKENVCQNC CCCHHHHHHHHHHCH	42.38	-
1580	Acetylation	LTEMPRGKFICNECR CCCCCCCCCCCCCCC	32.60	26051181
1631	Acetylation	PPTVMQNKGFRCSLH CCCHHCCCCCCEEEE	42.40	26051181
1694	Phosphorylation	IICPNHFTPRRGCRN EECCCCCCCCCCCCC	14.34	28555341
1815	Phosphorylation	HQARVFPYMEGDVSS CEEECCCCCCCCCCC	9.06	20736484
1833	Phosphorylation	MGKGVDGTYKKALQE CCCCCCCHHHHHHHH	27.92	28509920
1871	Ubiquitination	DKKPPPYKHIKVNRP CCCCCCCCCCCCCCC	44.63	-
1886	Phosphorylation	IGRVQIFTADLSEIP CCEEEEEECCHHHCC	22.38	24850871
1890	Phosphorylation	QIFTADLSEIPRCNC EEEECCHHHCCCCCC	33.74	-
1964	Ubiquitination	RTKTDIKKGEFVNEY CCCCCCCCCCCHHHH	65.10	-
1986	Dimethylation	EECRARIRYAQEHDI HHHHHHHHHHHHCCC	18.38	-
1986	Methylation	EECRARIRYAQEHDI HHHHHHHHHHHHCCC	18.38	24380857
1987	Phosphorylation	ECRARIRYAQEHDIT HHHHHHHHHHHCCCC	15.40	22210691
1994	Phosphorylation	YAQEHDITNFYMLTL HHHHCCCCCEEEEEE	25.90	-
2012	Ubiquitination	RIIDAGPKGNYARFM CEECCCCCCCHHHHH	59.89	-
2086	Acetylation	GFLGVRPKNQPIATE CCCCCCCCCCCCCCH	58.62	20167786
2095	Acetylation	QPIATEEKSKKFKKK CCCCCHHHHHHHHHH	62.43	20167786
2100 (in isoform 2)	Phosphorylation	-	68.86	-
2109	Phosphorylation	KQQGKRRTQGEITKE HHHCCCCCCCCCCCC	44.98	28985074
2109 (in isoform 2)	Phosphorylation	-	44.98	-
2132	Phosphorylation	GDAGQLVSCKKPGCP CCCCCEECCCCCCCC	28.89	28555341
2193 (in isoform 2)	Phosphorylation	-	2.90	-
2202 (in isoform 2)	Phosphorylation	-	6.48	-
2263	Phosphorylation	ADTNQMLSLSKKALA CCHHHHHHHCHHHHC	25.84	24719451
2288	Phosphorylation	RPLERTDSRPQPLDK CCCCCCCCCCCCCHH	45.29	28348404
2304 (in isoform 2)	Phosphorylation	-	29.26	-
2330	Phosphorylation	AGPRPQLSDKPSPVT CCCCCCCCCCCCCCC	38.04	27732954
2330 (in isoform 2)	Phosphorylation	-	38.04	-
2334	Phosphorylation	PQLSDKPSPVTSPSS CCCCCCCCCCCCCCC	37.43	25159151
2337	Phosphorylation	SDKPSPVTSPSSSPS CCCCCCCCCCCCCCC	38.00	27732954
2338	Phosphorylation	DKPSPVTSPSSSPSV CCCCCCCCCCCCCCH	24.02	27732954
2340	Phosphorylation	PSPVTSPSSSPSVRS CCCCCCCCCCCCHHC	43.12	26699800
2341	Phosphorylation	SPVTSPSSSPSVRSQ CCCCCCCCCCCHHCC	50.05	25159151
2342	Phosphorylation	PVTSPSSSPSVRSQP CCCCCCCCCCHHCCC	26.07	26699800
2344	Phosphorylation	TSPSSSPSVRSQPLE CCCCCCCCHHCCCCC	31.91	27732954
2364	Phosphorylation	ADPRLDKSIGAASPR CCCCCCCCCCCCCCC	26.39	28450419
2369	Phosphorylation	DKSIGAASPRPQSLE CCCCCCCCCCCCCCC	22.40	30266825
2374	Phosphorylation	AASPRPQSLEKTSVP CCCCCCCCCCCCCCC	40.97	30266825
2378	Phosphorylation	RPQSLEKTSVPTGLR CCCCCCCCCCCCCCC	26.11	20068231
2379	Phosphorylation	PQSLEKTSVPTGLRL CCCCCCCCCCCCCCC	36.85	20068231
2382	Phosphorylation	LEKTSVPTGLRLPPP CCCCCCCCCCCCCCC	46.85	20068231
2385	Methylation	TSVPTGLRLPPPDRL CCCCCCCCCCCCCCE	46.63	115485605
2395	Phosphorylation	PPDRLLITSSPKPQT CCCCEEECCCCCCCC	24.11	24732914
2396	Phosphorylation	PDRLLITSSPKPQTS CCCEEECCCCCCCCC	37.33	26074081
2397	Phosphorylation	DRLLITSSPKPQTSD CCEEECCCCCCCCCC	28.44	24732914
2402	Phosphorylation	TSSPKPQTSDRPTDK CCCCCCCCCCCCCCC	40.91	24732914
2403	Phosphorylation	SSPKPQTSDRPTDKP CCCCCCCCCCCCCCC	26.78	22210691
2407	Phosphorylation	PQTSDRPTDKPHASL CCCCCCCCCCCCCCH	58.51	24732914
2413	Phosphorylation	PTDKPHASLSQRLPP CCCCCCCCHHHCCCC	26.06	28555341
2437	Acetylation	QTLVAKEKALRPVDQ HHHHHHHHHCCCCCC	52.60	25953088
2462	Phosphorylation	VMDLIDLTPRQKERA HHHHHHCCHHHHHHC	16.81	22199227
2471	Phosphorylation	RQKERAASPHQVTPQ HHHHHCCCCCCCCCC	23.17	29255136
2476	Phosphorylation	AASPHQVTPQADEKM CCCCCCCCCCCCCCC	11.78	23401153
2506	Acetylation	HMPRAVEKGCVSDPL CCCHHHHCCCCCCCC	51.52	26051181
2506	Methylation	HMPRAVEKGCVSDPL CCCHHHHCCCCCCCC	51.52	115974221
2518	Methylation	DPLQTSGKAAAPSED CCCCCCCCCCCCCCC	34.32	115974229
2531	Ubiquitination	EDPWQAVKSLTQARL CCHHHHHHHHHHHHH	42.64	-
2545	Sumoylation	LLSQPPAKAFLYEPT HHCCCCCEEEEEECC	45.50	-
2545	Sumoylation	LLSQPPAKAFLYEPT HHCCCCCEEEEEECC	45.50	-
2549	Phosphorylation	PPAKAFLYEPTTQAS CCCEEEEEECCCCCC	17.26	27642862
2560	Phosphorylation	TQASGRASAGAEQTP CCCCCCCCCCCCCCC	26.35	27050516
2566	Phosphorylation	ASAGAEQTPGPLSQS CCCCCCCCCCCCHHC	23.01	29978859
2571	Phosphorylation	EQTPGPLSQSPGLVK CCCCCCCHHCCHHHH	31.57	25159151
2573	Phosphorylation	TPGPLSQSPGLVKQA CCCCCHHCCHHHHHH	19.98	25159151
2581	Methylation	PGLVKQAKQMVGGQQ CHHHHHHHHHHCCCC	36.11	115974237
2599	Phosphorylation	LAAKSGQSFRSLGKA HHHHCCCCHHHCCCC	26.59	17081983
2605	Acetylation	QSFRSLGKAPASLPT CCHHHCCCCCCCCCC	57.39	25953088
2616	Sumoylation	SLPTEEKKLVTTEQS CCCCCCCCCCCCCCC	52.01	-
2616	Sumoylation	SLPTEEKKLVTTEQS CCCCCCCCCCCCCCC	52.01	25218447
2616	Ubiquitination	SLPTEEKKLVTTEQS CCCCCCCCCCCCCCC	52.01	-
2623	Phosphorylation	KLVTTEQSPWALGKA CCCCCCCCHHHCCCC	19.04	25159151
2664	Phosphorylation	TLAQTCWSLGRGQDP HHHHHHHHCCCCCCC	24.08	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN496_HUMAN	ZNF496	physical	15169884
ANDR_HUMAN	AR	physical	11509567
AFF1_HUMAN	AFF1	physical	21030982
TNR21_HUMAN	TNFRSF21	physical	15623156
RARA_HUMAN	RARA	physical	23975195
RXRA_HUMAN	RXRA	physical	23975195
ESR1_HUMAN	ESR1	physical	23975195
PPARG_HUMAN	PPARG	physical	23975195
VDR_HUMAN	VDR	physical	23975195
THB_HUMAN	THRB	physical	23975195
RORA_HUMAN	RORA	physical	23975195
HNF4G_HUMAN	HNF4G	physical	23975195
NR2F6_HUMAN	NR2F6	physical	23975195
ERR1_HUMAN	ESRRA	physical	23975195
NR5A2_HUMAN	NR5A2	physical	23975195
NR6A1_HUMAN	NR6A1	physical	23975195
ANDR_HUMAN	AR	physical	23975195
COT1_HUMAN	NR2F1	physical	23975195
COT2_HUMAN	NR2F2	physical	23975195
NR2E1_HUMAN	NR2E1	physical	23975195
H31T_HUMAN	HIST3H3	physical	24412544
H15_HUMAN	HIST1H1B	physical	24412544
ATRX_HUMAN	ATRX	physical	24412544
H13_HUMAN	HIST1H1D	physical	24412544
H12_HUMAN	HIST1H1C	physical	24412544
H31_HUMAN	HIST1H3A	physical	25494638

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 117550: Sotos syndrome 1 (SOTOS1)
• 130650: Beckwith-Wiedemann syndrome (BWS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, AND MASSSPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483 AND SER-486, ANDMASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2471, AND MASSSPECTROMETRY.
PubMed: 18669648

"Toward a global characterization of the phosphoproteome in prostatecancer cells: identification of phosphoproteins in the LNCaP cellline.";
Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.;
Electrophoresis 28:2027-2034(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-766, AND MASSSPECTROMETRY.
PubMed: 17487921