HNF4G_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HNF4G_HUMAN
• UniProt AC: Q14541
• Protein Name: Hepatocyte nuclear factor 4-gamma
• Gene Name: HNF4G
• Organism: Homo sapiens (Human).
• Sequence Length: 408
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor. Has a lower transcription activation potential than HNF4-alpha..
• Protein Sequence: MNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMSTLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVISHQHLSKQKQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	DRATGKHYGASSCDG CCCCCCCCCCCCCCC	20.20	-
27	Phosphorylation	TGKHYGASSCDGCKG CCCCCCCCCCCCCCC	27.43	-
28	Phosphorylation	GKHYGASSCDGCKGF CCCCCCCCCCCCCCH	18.72	-
58	Acetylation	SRQCVVDKDKRNQCR ECEEEECCCCCCCHH	54.24	-
94	Phosphorylation	DRISTRRSTFDGSNI HHHHHCCCCCCCCCC	30.09	26657352
95	Acetylation	RISTRRSTFDGSNIP HHHHCCCCCCCCCCC	24.76	-
95	Phosphorylation	RISTRRSTFDGSNIP HHHHCCCCCCCCCCC	24.76	26657352
99	Phosphorylation	RRSTFDGSNIPSINT CCCCCCCCCCCCHHH	33.17	29083192
103	Phosphorylation	FDGSNIPSINTLAQA CCCCCCCCHHHHHHH	25.36	29083192
106	Phosphorylation	SNIPSINTLAQAEVR CCCCCHHHHHHHHHH	23.08	29083192
114	Phosphorylation	LAQAEVRSRQISVSS HHHHHHHHCCEEEEC	33.44	29083192
118	Phosphorylation	EVRSRQISVSSPGSS HHHHCCEEEECCCCC	13.96	30108239
120	Phosphorylation	RSRQISVSSPGSSTD HHCCEEEECCCCCCC	24.83	26657352
121	Phosphorylation	SRQISVSSPGSSTDI HCCEEEECCCCCCCC	30.99	30108239
124	Phosphorylation	ISVSSPGSSTDINVK EEEECCCCCCCCCHH	33.19	30108239
125	Phosphorylation	SVSSPGSSTDINVKK EEECCCCCCCCCHHH	35.69	29978859
126	Phosphorylation	VSSPGSSTDINVKKI EECCCCCCCCCHHHH	42.46	30108239
155	Phosphorylation	LVLVEWAKYIPAFCE HHHHHHHHHCHHHHC	44.80	-
156	Phosphorylation	VLVEWAKYIPAFCEL HHHHHHHHCHHHHCC	12.37	29083192
158	Phosphorylation	VEWAKYIPAFCELPL HHHHHHCHHHHCCCC	19.05	-
163	Phosphorylation	YIPAFCELPLDDQVA HCHHHHCCCCCHHHH	5.55	-
191	Phosphorylation	ATKRSMMYKDILLLG CCHHHHHHHHEEEEC	9.25	28387310
370	Phosphorylation	VHADQISTPETPLPS EEHHHCCCCCCCCCC	27.12	-
373	Phosphorylation	DQISTPETPLPSPPQ HHCCCCCCCCCCCCC	31.18	-
377	Phosphorylation	TPETPLPSPPQGSGQ CCCCCCCCCCCCCCH	57.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HNF4G_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HNF4G_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HNF4G_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNNI2_HUMAN	TNNI2	physical	15604093
G3P_HUMAN	GAPDH	physical	15604093
PRDX6_HUMAN	PRDX6	physical	15604093
RANB9_HUMAN	RANBP9	physical	15604093
HAX1_HUMAN	HAX1	physical	15604093
PNRC1_HUMAN	PNRC1	physical	15604093
PNRC2_HUMAN	PNRC2	physical	15604093
CSN5_HUMAN	COPS5	physical	15604093
NR0B2_HUMAN	NR0B2	physical	15604093
NCOA1_HUMAN	NCOA1	physical	23975195
PRS8_HUMAN	PSMC5	physical	15604093
NCOA1_HUMAN	NCOA1	physical	15604093

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.