THB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THB_HUMAN
• UniProt AC: P10828
• Protein Name: Thyroid hormone receptor beta
• Gene Name: THRB
• Organism: Homo sapiens (Human).
• Sequence Length: 461
• Subcellular Localization: Nucleus.
• Protein Description: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine..
• Protein Sequence: MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTPNSMTEN ------CCCCCCCCC	31.04	29759185
5	Phosphorylation	---MTPNSMTENGLT ---CCCCCCCCCCCC	28.43	24719451
12	Phosphorylation	SMTENGLTAWDKPKH CCCCCCCCCCCCCCC	27.40	29759185
50	Sumoylation	SERRSTLKNEQSSPH HHHHHHHCCCCCCCC	59.53	-
50	Sumoylation	SERRSTLKNEQSSPH HHHHHHHCCCCCCCC	59.53	-
55	Phosphorylation	TLKNEQSSPHLIQTT HHCCCCCCCCEEEEE	18.94	24275569
142	Phosphorylation	IQKNLHPSYSCKYEG HHHHCCCCCCCCCCC	20.94	12809513
146	Sumoylation	LHPSYSCKYEGKCVI CCCCCCCCCCCEEEE	40.16	-
146	Sumoylation	LHPSYSCKYEGKCVI CCCCCCCCCCCEEEE	40.16	-
171	Phosphorylation	CRFKKCIYVGMATDL CCCCCCEEECCCHHH	10.62	-
270	Phosphorylation	KVDLEAFSHFTKIIT CCCHHHHHHHHHHHH	25.41	26270265
273	Phosphorylation	LEAFSHFTKIITPAI HHHHHHHHHHHHHHH	18.86	26270265
406	Phosphorylation	FLLAFEHYINYRKHH HHHHHHHHHHHHHHH	5.44	18083107
443	Sumoylation	ASRFLHMKVECPTEL HHHHHCCEEECCHHH	24.92	-
443	Sumoylation	ASRFLHMKVECPTEL HHHHHCCEEECCHHH	24.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
142	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
142	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
406	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS8_HUMAN	PSMC5	physical	7870181
BRD8_HUMAN	BRD8	physical	9368056
NCOA2_HUMAN	NCOA2	physical	11518802
RXRA_HUMAN	RXRA	physical	9368056
TBL1X_HUMAN	TBL1X	physical	10809664
NCOA6_HUMAN	NCOA6	physical	10823961
TRIP4_HUMAN	TRIP4	physical	10454579
TS101_HUMAN	TSG101	physical	10508170
P53_HUMAN	TP53	physical	11258898
NCOA6_HUMAN	NCOA6	physical	11773444
CSN2_HUMAN	COPS2	physical	10207062
THB_HUMAN	THRB	physical	9751500
NCOR2_HUMAN	NCOR2	physical	9751500
NCOA1_HUMAN	NCOA1	physical	9751500
NCOA1_HUMAN	NCOA1	physical	9171239
NCOR2_HUMAN	NCOR2	physical	11518802
RXRA_HUMAN	RXRA	physical	9415406
NCOR2_HUMAN	NCOR2	physical	9415406
PRKDC_HUMAN	PRKDC	physical	17242407
NCOR1_HUMAN	NCOR1	physical	17242407
NCOR2_HUMAN	NCOR2	physical	17242407
SMC1A_HUMAN	SMC1A	physical	17242407
PARP1_HUMAN	PARP1	physical	17242407
DNLI3_HUMAN	LIG3	physical	17242407
XRCC5_HUMAN	XRCC5	physical	17242407
XRCC6_HUMAN	XRCC6	physical	17242407
HSP74_HUMAN	HSPA4	physical	17242407
TBL1R_HUMAN	TBL1XR1	physical	17242407
HDAC3_HUMAN	HDAC3	physical	17242407
GPS2_HUMAN	GPS2	physical	17242407
TBL1X_HUMAN	TBL1X	physical	17242407
KCC2B_HUMAN	CAMK2B	physical	15604093
RXRA_HUMAN	RXRA	physical	15604093
NRIP1_HUMAN	NRIP1	physical	15604093
NCOA1_HUMAN	NCOA1	physical	15604093
HMGN3_HUMAN	HMGN3	physical	15604093
NCOA3_HUMAN	NCOA3	physical	15604093
RXRG_HUMAN	RXRG	physical	15604093
RXRB_HUMAN	RXRB	physical	15604093
MED21_HUMAN	MED21	physical	15249124
NCOA3_HUMAN	NCOA3	physical	9346901
NCOA3_HUMAN	NCOA3	physical	20956942
ATF2_HUMAN	ATF2	physical	20956942
THB_HUMAN	THRB	physical	9162076
RXRA_HUMAN	RXRA	physical	9162076
RXRA_HUMAN	RXRA	physical	9582446
THB_HUMAN	THRB	physical	19422879
RXRA_HUMAN	RXRA	physical	19422879
NCOR1_HUMAN	NCOR1	physical	7566114
RANB9_HUMAN	RANBP9	physical	16595702
NCOA1_HUMAN	NCOA1	physical	23975195
NCOA1_HUMAN	NCOA1	physical	10454579
PRS8_HUMAN	PSMC5	physical	9368056
PRS8_HUMAN	PSMC5	physical	15604093
NCOA1_HUMAN	NCOA1	physical	9121466
NCOR1_HUMAN	NCOR1	physical	9121466
NCOR1_HUMAN	NCOR1	physical	25572392
ACTA_HUMAN	ACTA2	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442
PDLI7_HUMAN	PDLIM7	physical	28514442
DYN3_HUMAN	DNM3	physical	28514442
RASN_HUMAN	NRAS	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 188570: Generalized thyroid hormone resistance (GTHR)
• 274300: Generalized thyroid hormone resistance autosomal recessive (GTHRAR)
• 145650: Selective pituitary thyroid hormone resistance (PRTH)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00509: Dextrothyroxine
• DB00451: Levothyroxine
• DB00279: Liothyronine
• DB01583: Liotrix