TNR21_HUMAN - dbPTM
TNR21_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TNR21_HUMAN
UniProt AC O75509
Protein Name Tumor necrosis factor receptor superfamily member 21
Gene Name TNFRSF21
Organism Homo sapiens (Human).
Sequence Length 655
Subcellular Localization Cell membrane
Single-pass type I membrane protein .
Protein Description Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation..
Protein Sequence MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLLVLVVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MGTSPSSSTAL
----CCCCCCHHHHH		19.63-
13PhosphorylationSSSTALASCSRIARR
CHHHHHHHHHHHHHH		17.30-
22PhosphorylationSRIARRATATMIAGS
HHHHHHHHHHHHHHH		22.35-
24PhosphorylationIARRATATMIAGSLL
HHHHHHHHHHHHHHH		12.54-
82N-linked_GlycosylationYVSEHCTNTSLRVCS
EECCCCCCCCEEEEC		32.8219654028
141N-linked_GlycosylationPPGMFQSNATCAPHT
CCCCCCCCCCCCCCC		28.6119654028
177PhosphorylationQCARGTFSDVPSSVM
HHCCCCCCCCCHHHH		37.22-
181PhosphorylationGTFSDVPSSVMKCKA
CCCCCCCHHHHHCHH		35.10-
182PhosphorylationTFSDVPSSVMKCKAY
CCCCCCHHHHHCHHH		21.84-
227O-linked_GlycosylationSTSPSPGTAIFPRPE
CCCCCCCEEEECCCC		21.69OGP
252N-linked_GlycosylationTYVPKGMNSTESNSS
CCCCCCCCCCCCCCC		55.2219654028
253PhosphorylationYVPKGMNSTESNSSA
CCCCCCCCCCCCCCC		25.3524114839
254PhosphorylationVPKGMNSTESNSSAS
CCCCCCCCCCCCCCC		38.1324114839
256PhosphorylationKGMNSTESNSSASVR
CCCCCCCCCCCCCCC		41.9424114839
257N-linked_GlycosylationGMNSTESNSSASVRP
CCCCCCCCCCCCCCH		33.4819654028
261PhosphorylationTESNSSASVRPKVLS
CCCCCCCCCCHHHHH		22.1724114839
268PhosphorylationSVRPKVLSSIQEGTV
CCCHHHHHHHHCCCC		28.5129978859
269PhosphorylationVRPKVLSSIQEGTVP
CCHHHHHHHHCCCCC		24.9129978859
274PhosphorylationLSSIQEGTVPDNTSS
HHHHHCCCCCCCCCC		28.2829978859
278N-linked_GlycosylationQEGTVPDNTSSARGK
HCCCCCCCCCCCCCH		35.4719654028
289N-linked_GlycosylationARGKEDVNKTLPNLQ
CCCHHHHHHHCCCCE		43.8719654028
291O-linked_GlycosylationGKEDVNKTLPNLQVV
CHHHHHHHCCCCEEC		42.09OGP
315PhosphorylationHILKLLPSMEATGGE
HHHHHHHHCEECCCC		29.2622985185
315O-linked_GlycosylationHILKLLPSMEATGGE
HHHHHHHHCEECCCC		29.26OGP
319PhosphorylationLLPSMEATGGEKSST
HHHHCEECCCCCCCC		32.2022985185
368S-palmitoylationVLVVIVVCSIRKSSR
HHHHHHHHHHHHCCC		1.6219654028
376PhosphorylationSIRKSSRTLKKGPRQ
HHHHCCCCCCCCCCC		44.89-
386PhosphorylationKGPRQDPSAIVEKAG
CCCCCCHHHHHHHHC		38.6330576142
397PhosphorylationEKAGLKKSMTPTQNR
HHHCCCCCCCCCCCH		26.7123312004
399PhosphorylationAGLKKSMTPTQNREK
HCCCCCCCCCCCHHH		30.2123312004
401PhosphorylationLKKSMTPTQNREKWI
CCCCCCCCCCHHHEE		29.3423312004
409PhosphorylationQNREKWIYYCNGHGI
CCHHHEEEEECCCCC		10.80-
410PhosphorylationNREKWIYYCNGHGID
CHHHEEEEECCCCCH		3.13-
434PhosphorylationGSQWKDIYQFLCNAS
CCCHHHHHHHHHCCC		11.89-
460PhosphorylationTADHERAYAALQHWT
CCHHHHHHHHHHHCE		9.9128442448
514PhosphorylationDKLALPMSPSPLSPS
CCCCCCCCCCCCCCC		21.9323090842
516PhosphorylationLALPMSPSPLSPSPI
CCCCCCCCCCCCCCC		31.0323403867
519PhosphorylationPMSPSPLSPSPIPSP
CCCCCCCCCCCCCCC		27.0723403867
521PhosphorylationSPSPLSPSPIPSPNA
CCCCCCCCCCCCCCC		31.8923403867
525PhosphorylationLSPSPIPSPNAKLEN
CCCCCCCCCCCCCCC		31.3523403867
533PhosphorylationPNAKLENSALLTVEP
CCCCCCCCCCEEECC		15.7728176443
537PhosphorylationLENSALLTVEPSPQD
CCCCCCEEECCCCCC		24.5530108239
541PhosphorylationALLTVEPSPQDKNKG
CCEEECCCCCCCCCC		22.9929255136
545AcetylationVEPSPQDKNKGFFVD
ECCCCCCCCCCCCCC		56.1419823529
547AcetylationPSPQDKNKGFFVDES
CCCCCCCCCCCCCCC		63.9419823537
547UbiquitinationPSPQDKNKGFFVDES
CCCCCCCCCCCCCCC		63.94-
554PhosphorylationKGFFVDESEPLLRCD
CCCCCCCCCCCEECC		39.8023090842
562PhosphorylationEPLLRCDSTSSGSSA
CCCEECCCCCCCCCH		33.5423090842
563PhosphorylationPLLRCDSTSSGSSAL
CCEECCCCCCCCCHH		17.4123090842
564PhosphorylationLLRCDSTSSGSSALS
CEECCCCCCCCCHHH		36.3323090842
565PhosphorylationLRCDSTSSGSSALSR
EECCCCCCCCCHHHH		42.6623090842
567PhosphorylationCDSTSSGSSALSRNG
CCCCCCCCCHHHHCC		17.8723090842
568PhosphorylationDSTSSGSSALSRNGS
CCCCCCCCHHHHCCC		36.4323090842
571PhosphorylationSSGSSALSRNGSFIT
CCCCCHHHHCCCCCC		24.3423090842
575PhosphorylationSALSRNGSFITKEKK
CHHHHCCCCCCHHCC		19.6128102081
578PhosphorylationSRNGSFITKEKKDTV
HHCCCCCCHHCCCCE		31.0128102081
584PhosphorylationITKEKKDTVLRQVRL
CCHHCCCCEEEEECC		30.2523532336
648PhosphorylationQTLLDSVYSHLPDLL
HHHHHHHHHHCCCCC		8.3725884760
649PhosphorylationTLLDSVYSHLPDLL-
HHHHHHHHHCCCCC-		19.18-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TNR21_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TNR21_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TNR21_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRADD_HUMANTRADDphysical
9714541
MATR3_HUMANMATR3physical
21900206
STX11_HUMANSTX11physical
21900206
PSMD4_HUMANPSMD4physical
24829148
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TNR21_HUMAN

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Related Literatures of Post-Translational Modification

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