FBW1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBW1A_MOUSE
• UniProt AC: Q3ULA2
• Protein Name: F-box/WD repeat-containing protein 1A {ECO:0000250|UniProtKB:Q9Y297, ECO:0000312|EMBL:AAL40929.1}
• Gene Name: Btrc {ECO:0000312|MGI:MGI:1338871}
• Organism: Mus musculus (Mouse).
• Sequence Length: 605
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. [PubMed: 10097128]
• Protein Sequence: MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCINQETVCLTSTAMKTENCVAKAKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDENAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNAGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLMAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAHAEPPRSPSRTYTYISR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	RSLWLGCSSLADSMP CHHHCCCCHHHHHCC	26.96	-
36	Phosphorylation	SLADSMPSLRCLYNP HHHHHCCCCEEEECC	21.58	-
127	Phosphorylation	VPKQRKLSASYEKEK CCCCCCCCCCHHHHH	20.43	26824392
129	Phosphorylation	KQRKLSASYEKEKEL CCCCCCCCHHHHHHH	30.37	25777480
130	Phosphorylation	QRKLSASYEKEKELC CCCCCCCHHHHHHHH	30.64	25777480
266	Phosphorylation	DENAPPNSFYRALYP CCCCCCCHHHHHHHH	29.45	28285833
292	Phosphorylation	NWRCGRHSLQRIHCR HCCCCCHHCEEEEEC	25.49	22324799
437	Ubiquitination	NVVDFDDKYIVSASG EEEECCCCEEEECCC	38.43	-
595	Phosphorylation	AHAEPPRSPSRTYTY HCCCCCCCCCCCEEE	32.76	25338131
597	Phosphorylation	AEPPRSPSRTYTYIS CCCCCCCCCCEEEEC	38.20	29514104
600	Phosphorylation	PRSPSRTYTYISR-- CCCCCCCEEEECC--	9.09	29514104
602	Phosphorylation	SPSRTYTYISR---- CCCCCEEEECC----	6.10	29514104
604	Phosphorylation	SRTYTYISR------ CCCEEEECC------	22.86	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBW1A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBW1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBW1A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLI2_MOUSE	Gli2	physical	16611981
NF2L2_MOUSE	Nfe2l2	physical	21245377
SKP1_MOUSE	Skp1a	physical	10097128
CUL1_MOUSE	Cul1	physical	10097128
IKBA_MOUSE	Nfkbia	physical	10097128
MPIP2_MOUSE	Cdc25b	physical	21807946
PER2_RAT	Per2	physical	18782782
PER1_MOUSE	Per1	physical	17462724
PER2_MOUSE	Per2	physical	17462724
SKP1_MOUSE	Skp1a	physical	18929646
NF2L2_MOUSE	Nfe2l2	physical	22964642
CUL1_MOUSE	Cul1	physical	11735228
SKP1_MOUSE	Skp1a	physical	11735228
TPX2_MOUSE	Tpx2	physical	24115035
ZRAN1_HUMAN	ZRANB1	physical	18281465
PKD2_MOUSE	Pkd2	physical	17636028
SMAD4_MOUSE	Smad4	physical	26022109
GA45A_MOUSE	Gadd45a	physical	26022109

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.