CUL1_MOUSE - dbPTM
CUL1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CUL1_MOUSE
UniProt AC Q9WTX6
Protein Name Cullin-1
Gene Name Cul1
Organism Mus musculus (Mouse).
Sequence Length 776
Subcellular Localization
Protein Description Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2..
Protein Sequence MSSNRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSNRSQNP
------CCCCCCCCC		36.0029514104
3Phosphorylation-----MSSNRSQNPH
-----CCCCCCCCCC		34.6625338131
6Phosphorylation--MSSNRSQNPHGLK
--CCCCCCCCCCCHH		38.2629514104
63MethylationVHQSNQARGAGVPPS
HHHHCCCCCCCCCCC		26.2324129315
410UbiquitinationINNNAVTKMAQSSSK
HCHHHHHHHHHCCCC		26.1627667366
720UbiquitinationAAIVRIMKMRKVLKH
HHHHHHHHHHHHHHH		32.93-
750UbiquitinationKPRVPVIKKCIDILI
CCCCHHHHHHHHHHH		41.6527667366
751MalonylationPRVPVIKKCIDILIE
CCCHHHHHHHHHHHH		25.8726320211
769UbiquitinationLERVDGEKDTYSYLA
HHHCCCCCCCCCCCC		61.98-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CUL1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CUL1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CUL1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAND2_MOUSECand2physical
17242400
SKP1_MOUSESkp1aphysical
17242400
MYOG_MOUSEMyogphysical
17242400
SKP1_MOUSESkp1aphysical
18929646
SKP1_MOUSESkp1aphysical
12417738
SKP2_MOUSESkp2physical
12417738
RBX1_MOUSERbx1physical
12417738
SKP1_MOUSESkp1aphysical
17290223
CAND1_MOUSECand1physical
17290223
CHK1_MOUSEChek1physical
17290223
FBXW8_MOUSEFbxw8physical
16880526
CUL7_MOUSECul7physical
16880526
SKP1_MOUSESkp1aphysical
16880526
RBX1_MOUSERbx1physical
16880526
CD97_HUMANCD97physical
26496610
NC2B_HUMANDR1physical
26496610
FOXM1_HUMANFOXM1physical
26496610
GABP1_HUMANGABPB1physical
26496610
CSN1_HUMANGPS1physical
26496610
IL18_HUMANIL18physical
26496610
PSMD5_HUMANPSMD5physical
26496610
REQU_HUMANDPF2physical
26496610
SKP2_HUMANSKP2physical
26496610
TTC3_HUMANTTC3physical
26496610
SF01_HUMANSF1physical
26496610
UBP11_HUMANUSP11physical
26496610
CSN3_HUMANCOPS3physical
26496610
MKNK1_HUMANMKNK1physical
26496610
RECQ5_HUMANRECQL5physical
26496610
RBX1_HUMANRBX1physical
26496610
RBP1_HUMANRALBP1physical
26496610
1433T_HUMANYWHAQphysical
26496610
SYNE2_HUMANSYNE2physical
26496610
FBX7_HUMANFBXO7physical
26496610
LTN1_HUMANLTN1physical
26496610
UTP11_HUMANUTP11Lphysical
26496610
NO40_HUMANZCCHC17physical
26496610
NUP54_HUMANNUP54physical
26496610
SYIM_HUMANIARS2physical
26496610
CAND1_HUMANCAND1physical
26496610
S39AA_HUMANSLC39A10physical
26496610
CDCA3_HUMANCDCA3physical
26496610
RUSD4_HUMANRPUSD4physical
26496610
ARMC6_HUMANARMC6physical
26496610
RM52_HUMANMRPL52physical
26496610
CPEB2_HUMANCPEB2physical
26496610
EME1_HUMANEME1physical
26496610
GOG8R_HUMANGOLGA8Rphysical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CUL1_MOUSE

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Related Literatures of Post-Translational Modification

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