IL18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL18_HUMAN
• UniProt AC: Q14116
• Protein Name: Interleukin-18 {ECO:0000303|PubMed:14528293, ECO:0000303|PubMed:25261253, ECO:0000303|PubMed:25500532}
• Gene Name: IL18 {ECO:0000312|HGNC:HGNC:5986}
• Organism: Homo sapiens (Human).
• Sequence Length: 193
• Subcellular Localization: Secreted .
• Protein Description: A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. [PubMed: 14528293]
• Protein Sequence: MAAEPVEDNCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	KFIDNTLYFIAEDDE EHHCCEEEEEEECCC	7.30	27259358
35	Phosphorylation	EDDENLESDYFGKLE ECCCCCCCCCHHCHH	40.55	23532336
37	Phosphorylation	DENLESDYFGKLESK CCCCCCCCHHCHHHH	24.42	27259358
43	Phosphorylation	DYFGKLESKLSVIRN CCHHCHHHHHHHHCC	49.70	27259358
88	Phosphorylation	TIFIISMYKDSQPRG EEEEEEEECCCCCCC	12.59	-
106	Acetylation	TISVKCEKISTLSCE EEEEECEEEEEECEE	51.97	26051181
106	Ubiquitination	TISVKCEKISTLSCE EEEEECEEEEEECEE	51.97	-
115	Ubiquitination	STLSCENKIISFKEM EEECEECCEEECCCC	21.08	-
115	Acetylation	STLSCENKIISFKEM EEECEECCEEECCCC	21.08	23236377
118	Phosphorylation	SCENKIISFKEMNPP CEECCEEECCCCCCC	33.47	24719451
120	Ubiquitination	ENKIISFKEMNPPDN ECCEEECCCCCCCCC	49.62	21906983
120	Acetylation	ENKIISFKEMNPPDN ECCEEECCCCCCCCC	49.62	23954790
131	Phosphorylation	PPDNIKDTKSDIIFF CCCCCCCCCCCEEEE	27.69	23312004
132	Ubiquitination	PDNIKDTKSDIIFFQ CCCCCCCCCCEEEEE	57.15	-
132	Acetylation	PDNIKDTKSDIIFFQ CCCCCCCCCCEEEEE	57.15	23236377
132	Succinylation	PDNIKDTKSDIIFFQ CCCCCCCCCCEEEEE	57.15	23954790
133	Phosphorylation	DNIKDTKSDIIFFQR CCCCCCCCCEEEEEC	35.81	30266825
148	Ubiquitination	SVPGHDNKMQFESSS CCCCCCCCCCEECCC	39.89	-
171	Ubiquitination	EKERDLFKLILKKED HHHHHHHHHHHCCCC	41.75	-
171	2-Hydroxyisobutyrylation	EKERDLFKLILKKED HHHHHHHHHHHCCCC	41.75	-
176	Succinylation	LFKLILKKEDELGDR HHHHHHCCCCCCCCC	67.94	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL18_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
I18BP_HUMAN	IL18BP	physical	11907126
SPB4_HUMAN	SERPINB4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.