| UniProt ID | GABP1_HUMAN | |
|---|---|---|
| UniProt AC | Q06547 | |
| Protein Name | GA-binding protein subunit beta-1 | |
| Gene Name | GABPB1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 395 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.. | |
| Protein Sequence | MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLVDLGKK ------CCHHHHHHH | 36.78 | 27067055 | |
| 2 | Acetylation | ------MSLVDLGKK ------CCHHHHHHH | 36.78 | 22814378 | |
| 8 | Acetylation | MSLVDLGKKLLEAAR CCHHHHHHHHHHHHH | 47.77 | 25953088 | |
| 8 | Ubiquitination | MSLVDLGKKLLEAAR CCHHHHHHHHHHHHH | 47.77 | - | |
| 9 | Ubiquitination | SLVDLGKKLLEAARA CHHHHHHHHHHHHHC | 57.41 | 22053931 | |
| 9 (in isoform 4) | Ubiquitination | - | 57.41 | 22053931 | |
| 69 | Acetylation | VSRDARTKVDRTPLH CCCCCCCCCCCCCCH | 36.26 | - | |
| 92 | Ubiquitination | SIVEVLLKHGADVNA HHHHHHHHCCCCCCH | 35.51 | - | |
| 100 | Ubiquitination | HGADVNAKDMLKMTA CCCCCCHHHHHHHHH | 38.17 | - | |
| 126 | Nitration | VVELLIKYGADVHTQ HHHHHHHHCCCHHCC | 15.56 | - | |
| 135 | Acetylation | ADVHTQSKFCKTAFD CCHHCCCCCCCHHHE | 44.99 | 25953088 | |
| 135 | Ubiquitination | ADVHTQSKFCKTAFD CCHHCCCCCCCHHHE | 44.99 | - | |
| 180 | Phosphorylation | TVTIHAATPQFIIGP CEEEEEECCEEEECC | 20.57 | - | |
| 287 | O-linked_Glycosylation | IQLGNLHSIPTSGIG EECCCCCCCCCCCCC | 33.17 | 29485866 | |
| 291 | O-linked_Glycosylation | NLHSIPTSGIGQPII CCCCCCCCCCCCCEE | 24.06 | 29485866 | |
| 300 | O-linked_Glycosylation | IGQPIIVTMPDGQQV CCCCEEEECCCCCEE | 16.75 | 29485866 | |
| 329 (in isoform 4) | Phosphorylation | - | 38.41 | 21815630 | |
| 341 | Phosphorylation | IIENRVESAEIEERE HHHHHHHHHHHHHHH | 28.48 | 21815630 | |
| 341 (in isoform 3) | Phosphorylation | - | 28.48 | 21815630 | |
| 352 | Acetylation | EEREALQKQLDEANR HHHHHHHHHHHHHHH | 54.39 | - | |
| 364 | Phosphorylation | ANREAQKYRQQLLKK HHHHHHHHHHHHHHH | 11.11 | - | |
| 370 | Sumoylation | KYRQQLLKKEQEAEA HHHHHHHHHHHHHHH | 63.96 | - | |
| 370 | Sumoylation | KYRQQLLKKEQEAEA HHHHHHHHHHHHHHH | 63.96 | - | |
| 381 | Ubiquitination | EAEAYRQKLEAMTRL HHHHHHHHHHHHHHH | 39.02 | - | |
| 381 | Acetylation | EAEAYRQKLEAMTRL HHHHHHHHHHHHHHH | 39.02 | - | |
| 392 | Ubiquitination | MTRLQTNKEAV---- HHHHHHCHHCC---- | 50.90 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GABP1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GABP1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GABP1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| USO1_HUMAN | USO1 | physical | 16189514 | |
| LMO3_HUMAN | LMO3 | physical | 16189514 | |
| MAGBI_HUMAN | MAGEB18 | physical | 16189514 | |
| TDRD7_HUMAN | TDRD7 | physical | 16189514 | |
| GABPA_HUMAN | GABPA | physical | 22939629 | |
| RYBP_HUMAN | RYBP | physical | 11953439 | |
| YAF2_HUMAN | YAF2 | physical | 11953439 | |
| TYY1_HUMAN | YY1 | physical | 11953439 | |
| RBTN1_HUMAN | LMO1 | physical | 25416956 | |
| SNRPA_HUMAN | SNRPA | physical | 25416956 | |
| RU2B_HUMAN | SNRPB2 | physical | 25416956 | |
| TRAF2_HUMAN | TRAF2 | physical | 25416956 | |
| LMO4_HUMAN | LMO4 | physical | 25416956 | |
| POGZ_HUMAN | POGZ | physical | 25416956 | |
| TDRD7_HUMAN | TDRD7 | physical | 25416956 | |
| RSP14_HUMAN | RSPH14 | physical | 25416956 | |
| RBM11_HUMAN | RBM11 | physical | 25416956 | |
| F90A1_HUMAN | FAM90A1 | physical | 25416956 | |
| TPD54_HUMAN | TPD52L2 | physical | 26186194 | |
| GABPA_HUMAN | GABPA | physical | 26186194 | |
| TDRD7_HUMAN | TDRD7 | physical | 26186194 | |
| GABPA_HUMAN | GABPA | physical | 26344197 | |
| RBTN1_HUMAN | LMO1 | physical | 21516116 | |
| TRAF2_HUMAN | TRAF2 | physical | 21516116 | |
| GABPA_HUMAN | GABPA | physical | 28514442 | |
| TDRD7_HUMAN | TDRD7 | physical | 28514442 | |
| TPD54_HUMAN | TPD52L2 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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