GABPA_HUMAN - dbPTM
GABPA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GABPA_HUMAN
UniProt AC Q06546
Protein Name GA-binding protein alpha chain
Gene Name GABPA
Organism Homo sapiens (Human).
Sequence Length 454
Subcellular Localization Nucleus.
Protein Description Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene..
Protein Sequence MTKREAEELIEIEIDGTEKAECTEESIVEQTYAPAECVSQAIDINEPIGNLKKLLEPRLQCSLDAHEICLQDIQLDPERSLFDQGVKTDGTVQLSVQVISYQGIEPKLNILEIVKPADTVEVVIDPDAHHAESEAHLVEEAQVITLDGTKHITTISDETSEQVTRWAAALEGYRKEQERLGIPYDPIQWSTDQVLHWVVWVMKEFSMTDIDLTTLNISGRELCSLNQEDFFQRVPRGEILWSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASVQSATPTTIKVINSSAKAAKVQRAPRISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQPELVAQKWGQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLVTECEQKKLAKMQLHGIAQPVTAVALATASLQTEKDN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Sumoylation-----MTKREAEELI
-----CCHHHHHHHE		47.12-
23PhosphorylationGTEKAECTEESIVEQ
CCCCCCCCHHHHHCC		34.0027251275
26PhosphorylationKAECTEESIVEQTYA
CCCCCHHHHHCCCCC		26.2127251275
31PhosphorylationEESIVEQTYAPAECV
HHHHHCCCCCCHHHH		14.2427251275
32PhosphorylationESIVEQTYAPAECVS
HHHHCCCCCCHHHHH		15.4127251275
39PhosphorylationYAPAECVSQAIDINE
CCCHHHHHHHHCCCC		26.0827251275
62PhosphorylationLEPRLQCSLDAHEIC
HCHHHHCCCCHHHHH		19.1425849741
218PhosphorylationDLTTLNISGRELCSL
CCEEEECCCHHHCCC		30.63-
254O-linked_GlycosylationLRKYVLASQEQQMNE
HHHHHHHCHHHHHCC		30.0423301498
264O-linked_GlycosylationQQMNEIVTIDQPVQI
HHHCCCEEECCCEEE		25.2123301498
275O-linked_GlycosylationPVQIIPASVQSATPT
CEEEECCCCCCCCCC		18.4823301498
278O-linked_GlycosylationIIPASVQSATPTTIK
EECCCCCCCCCCEEE		31.7723301498
292UbiquitinationKVINSSAKAAKVQRA
EEECCCCHHHHCCCC		51.31-
292AcetylationKVINSSAKAAKVQRA
EEECCCCHHHHCCCC		51.3125953088
303PhosphorylationVQRAPRISGEDRSSP
CCCCCCCCCCCCCCC		37.0928355574
308O-linked_GlycosylationRISGEDRSSPGNRTG
CCCCCCCCCCCCCCC		53.8823301498
308PhosphorylationRISGEDRSSPGNRTG
CCCCCCCCCCCCCCC		53.8822496350
309PhosphorylationISGEDRSSPGNRTGN
CCCCCCCCCCCCCCC		37.4122496350
309O-linked_GlycosylationISGEDRSSPGNRTGN
CCCCCCCCCCCCCCC		37.4123301498
349SumoylationVGDEGEFKLNQPELV
CCCCCCEECCCHHHH		42.07-
349UbiquitinationVGDEGEFKLNQPELV
CCCCCCEECCCHHHH		42.07-
359UbiquitinationQPELVAQKWGQRKNK
CHHHHHHHHHCCCCC		43.4821890473
364AcetylationAQKWGQRKNKPTMNY
HHHHHCCCCCCCCCH		62.5320167786
366UbiquitinationKWGQRKNKPTMNYEK
HHHCCCCCCCCCHHH		44.92-
368PhosphorylationGQRKNKPTMNYEKLS
HCCCCCCCCCHHHHH		21.4729083192
371PhosphorylationKNKPTMNYEKLSRAL
CCCCCCCHHHHHHHH		12.0123403867
373SumoylationKPTMNYEKLSRALRY
CCCCCHHHHHHHHHH		41.21-
373AcetylationKPTMNYEKLSRALRY
CCCCCHHHHHHHHHH		41.2120167786
373UbiquitinationKPTMNYEKLSRALRY
CCCCCHHHHHHHHHH		41.21-
373SumoylationKPTMNYEKLSRALRY
CCCCCHHHHHHHHHH		41.21-
379MethylationEKLSRALRYYYDGDM
HHHHHHHHHHHCCCE		19.20-
380PhosphorylationKLSRALRYYYDGDMI
HHHHHHHHHHCCCEE		13.76-
381PhosphorylationLSRALRYYYDGDMIC
HHHHHHHHHCCCEEE		6.66-
382PhosphorylationSRALRYYYDGDMICK
HHHHHHHHCCCEEEE		12.43-
405PhosphorylationKFVCDLKTLIGYSAA
EEEECHHHHHCCCHH		30.7922985185
409PhosphorylationDLKTLIGYSAAELNR
CHHHHHCCCHHHHHH		6.5322985185
424AcetylationLVTECEQKKLAKMQL
HHHHHHHHHHHHHHH		27.7125953088
424UbiquitinationLVTECEQKKLAKMQL
HHHHHHHHHHHHHHH		27.71-
428UbiquitinationCEQKKLAKMQLHGIA
HHHHHHHHHHHCCCC		37.30-
439PhosphorylationHGIAQPVTAVALATA
CCCCHHHHHHHHHHH		23.3027307780
445PhosphorylationVTAVALATASLQTEK
HHHHHHHHHHHHHCC		20.0327307780
447PhosphorylationAVALATASLQTEKDN
HHHHHHHHHHHCCCC		19.3622817901
450PhosphorylationLATASLQTEKDN---
HHHHHHHHCCCC---		50.7427307780
452UbiquitinationTASLQTEKDN-----
HHHHHHCCCC-----		66.99-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GABPA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GABPA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GABPA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SP1_HUMANSP1physical
11237613
SP3_HUMANSP3physical
11237613
ATF1_HUMANATF1physical
10585419
MED1_HUMANMED1physical
16574658
EP300_HUMANEP300physical
17304221
HDAC1_HUMANHDAC1physical
17304221
A4_HUMANAPPphysical
21832049
GABP1_HUMANGABPB1physical
11953439
TYY1_HUMANYY1physical
11953439
PINX1_HUMANPINX1physical
21988832
CUTC_HUMANCUTCphysical
22863883
DBLOH_HUMANDIABLOphysical
22863883
RB3GP_HUMANRAB3GAP1physical
22863883
RBGPR_HUMANRAB3GAP2physical
22863883
SEN34_HUMANTSEN34physical
22863883
EP300_HUMANEP300physical
16581781
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GABPA_HUMAN

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Related Literatures of Post-Translational Modification

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