CUTC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CUTC_HUMAN
• UniProt AC: Q9NTM9
• Protein Name: Copper homeostasis protein cutC homolog
• Gene Name: CUTC
• Organism: Homo sapiens (Human).
• Sequence Length: 273
• Subcellular Localization: Cytoplasm . Nucleus . The overexpressed protein is detected in the cytoplasm, and depending on the cell line, also in the nucleus.
• Protein Description: May play a role in copper homeostasis. Can bind one Cu(1+) per subunit..
• Protein Sequence: MKRQGASSERKRARIPSGKAGAANGFLMEVCVDSVESAVNAERGGADRIELCSGLSEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREIEVMKADIRLAKLYGADGLVFGALTEDGHIDKELCMSLMAICRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIKRLIEQAKGRIVVMPGGGITDRNLQRILEGSGATEFHCSARSTRDSGMKFRNSSVAMGASLSCSEYSLKVTDVTKVRTLNAIAKNILV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	RKRARIPSGKAGAAN HHHHCCCCCCHHHCC	51.02	29496963
53	Phosphorylation	ADRIELCSGLSEGGT CCCEEECCCCCCCCC	56.23	-
63	Phosphorylation	SEGGTTPSMGVLQVV CCCCCCCCHHHHHHH	26.52	-
91	Phosphorylation	PRGGDFLYSDREIEV CCCCCCCCCCCCEEE	14.44	-
100	Ubiquitination	DREIEVMKADIRLAK CCCEEEEHHHHHHHH	48.35	24816145
100	Acetylation	DREIEVMKADIRLAK CCCEEEEHHHHHHHH	48.35	25038526
107	Ubiquitination	KADIRLAKLYGADGL HHHHHHHHHHCCCCE	47.00	29967540
160	Phosphorylation	DPMAALETLLTLGFE CHHHHHHHHHHHCHH	28.11	-
163	Phosphorylation	AALETLLTLGFERVL HHHHHHHHHCHHHHH	28.13	-
171	Phosphorylation	LGFERVLTSGCDSSA HCHHHHHCCCCCHHH	21.88	-
186	Acetylation	LEGLPLIKRLIEQAK HCCCHHHHHHHHHCC	49.16	25038526
186	Ubiquitination	LEGLPLIKRLIEQAK HCCCHHHHHHHHHCC	49.16	27667366
193	Ubiquitination	KRLIEQAKGRIVVMP HHHHHHCCCCEEEEC	48.71	29967540
224	Phosphorylation	GATEFHCSARSTRDS CCCEEEECCCCCCCC	20.39	26437602
234	Ubiquitination	STRDSGMKFRNSSVA CCCCCCCCCCCCCHH	44.70	-
234	Acetylation	STRDSGMKFRNSSVA CCCCCCCCCCCCCHH	44.70	25953088
238	Phosphorylation	SGMKFRNSSVAMGAS CCCCCCCCCHHHCCE	23.18	27080861
239	Phosphorylation	GMKFRNSSVAMGASL CCCCCCCCHHHCCEE	19.90	27080861
245	Phosphorylation	SSVAMGASLSCSEYS CCHHHCCEEECCCCC	18.32	27080861
247	Phosphorylation	VAMGASLSCSEYSLK HHHCCEEECCCCCCC	17.07	27080861
249	Phosphorylation	MGASLSCSEYSLKVT HCCEEECCCCCCCCC	35.87	27080861
251	Phosphorylation	ASLSCSEYSLKVTDV CEEECCCCCCCCCCH	11.74	25693802
252	Phosphorylation	SLSCSEYSLKVTDVT EEECCCCCCCCCCHH	20.05	27080861
254	Acetylation	SCSEYSLKVTDVTKV ECCCCCCCCCCHHHH	36.83	26051181
260	Ubiquitination	LKVTDVTKVRTLNAI CCCCCHHHHHHHHHH	29.57	32015554
269	Ubiquitination	RTLNAIAKNILV--- HHHHHHHHHCCC---	38.11	22505724

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CUTC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CUTC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CUTC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	16189514
NADE_HUMAN	NADSYN1	physical	16189514
CUTC_HUMAN	CUTC	physical	16189514
SPG21_HUMAN	SPG21	physical	16189514
NIF3L_HUMAN	NIF3L1	physical	16189514
NUD18_HUMAN	NUDT18	physical	16189514
CUTC_HUMAN	CUTC	physical	16169070
I2BP2_HUMAN	IRF2BP2	physical	22863883
PRRC1_HUMAN	PRRC1	physical	22863883
CUTC_HUMAN	CUTC	physical	25416956
SPG21_HUMAN	SPG21	physical	25416956
CEP76_HUMAN	CEP76	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.