dbPTM

I2BP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	I2BP2_HUMAN
UniProt AC	Q7Z5L9
Protein Name	Interferon regulatory factor 2-binding protein 2
Gene Name	IRF2BP2
Organism	Homo sapiens (Human).
Sequence Length	587
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle..
Protein Sequence	MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLKRAHGCFPEGRSPPGAAASAAAKPPPLSAKDILLQQQQQLGHGGPEAAPRAPQALERYPLAAAAERPPRLGSDFGSSRPAASLAQPPTPQPPPVNGILVPNGFSKLEEPPELNRQSPNPRRGHAVPPTLVPLMNGSATPLPTALGLGGRAAASLAAVSGTAAASLGSAQPTDLGAHKRPASVSSSAAVEHEQREAAAKEKQPPPPAHRGPADSLSTAAGAAELSAEGAGKSRGSGEQDWVNRPKTVRDTLLALHQHGHSGPFESKFKKEPALTAGRLLGFEANGANGSKAVARTARKRKPSPEPEGEVGPPKINGEAQPWLSTSTEGLKIPMTPTSSFVSPPPPTASPHSNRTTPPEAAQNGQSPMAALILVADNAGGSHASKDANQVHSTTRRNSNSPPSPSSMNQRRLGPREVGGQGAGNTGGLEPVHPASLPDSSLATSAPLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAVAVAA ------CHHHHHHHH	12.25	22814378
11	Phosphorylation	AVAVAAASRRQSCYL HHHHHHHHHCCCEEE	24.22	20068231
15	Phosphorylation	AAASRRQSCYLCDLP HHHHHCCCEEECCCC	11.69	25849741
17	Phosphorylation	ASRRQSCYLCDLPRM HHHCCCEEECCCCCC	18.66	28450419
71	Phosphorylation	GCFPEGRSPPGAAAS CCCCCCCCCCCHHHH	46.43	23401153
78	Phosphorylation	SPPGAAASAAAKPPP CCCCHHHHHHCCCCC	17.45	24702127
87	Phosphorylation	AAKPPPLSAKDILLQ HCCCCCCCHHHHHHH	38.76	24702127
89	Ubiquitination	KPPPLSAKDILLQQQ CCCCCCHHHHHHHHH	41.76	21890473
89 (in isoform 1)	Ubiquitination	-	41.76	21890473
89 (in isoform 2)	Ubiquitination	-	41.76	21890473
109	Methylation	GGPEAAPRAPQALER CCCCCCCCCCHHHHH	54.92	115480507
116	Methylation	RAPQALERYPLAAAA CCCHHHHHCCCHHHH	38.94	80702545
125	Methylation	PLAAAAERPPRLGSD CCHHHHCCCCCCCCC	41.62	115480499
131	Phosphorylation	ERPPRLGSDFGSSRP CCCCCCCCCCCCCCC	34.07	23401153
135	Phosphorylation	RLGSDFGSSRPAASL CCCCCCCCCCCCHHH	24.14	23312004
136	Phosphorylation	LGSDFGSSRPAASLA CCCCCCCCCCCHHHC	42.54	27794612
141	Phosphorylation	GSSRPAASLAQPPTP CCCCCCHHHCCCCCC	26.75	28450419
147	Phosphorylation	ASLAQPPTPQPPPVN HHHCCCCCCCCCCCC	41.04	28450419
163	Phosphorylation	ILVPNGFSKLEEPPE EECCCCCCCCCCCCC	37.42	22210691
175	Phosphorylation	PPELNRQSPNPRRGH CCCCCCCCCCCCCCC	24.33	29255136
195	Phosphorylation	LVPLMNGSATPLPTA CCCCCCCCCCCCCCH	24.78	21712546
197	Phosphorylation	PLMNGSATPLPTALG CCCCCCCCCCCCHHC	27.36	25159151
212	O-linked_Glycosylation	LGGRAAASLAAVSGT CCHHHHHHHHHHHCC	17.51	30059200
212	Phosphorylation	LGGRAAASLAAVSGT CCHHHHHHHHHHHCC	17.51	28555341
217	O-linked_Glycosylation	AASLAAVSGTAAASL HHHHHHHHCCHHHHC	26.21	30059200
217	Phosphorylation	AASLAAVSGTAAASL HHHHHHHHCCHHHHC	26.21	28555341
219	O-linked_Glycosylation	SLAAVSGTAAASLGS HHHHHHCCHHHHCCC	12.96	30059200
223	O-linked_Glycosylation	VSGTAAASLGSAQPT HHCCHHHHCCCCCCC	28.65	30059200
223	Phosphorylation	VSGTAAASLGSAQPT HHCCHHHHCCCCCCC	28.65	22210691
226	O-linked_Glycosylation	TAAASLGSAQPTDLG CHHHHCCCCCCCCCC	29.08	30059200
226	Phosphorylation	TAAASLGSAQPTDLG CHHHHCCCCCCCCCC	29.08	22210691
230	O-linked_Glycosylation	SLGSAQPTDLGAHKR HCCCCCCCCCCCCCC	31.60	30059200
230	Phosphorylation	SLGSAQPTDLGAHKR HCCCCCCCCCCCCCC	31.60	22210691
236	Acetylation	PTDLGAHKRPASVSS CCCCCCCCCCCCCCH	60.59	25953088
240	O-linked_Glycosylation	GAHKRPASVSSSAAV CCCCCCCCCCHHHHH	25.80	30059200
240	Phosphorylation	GAHKRPASVSSSAAV CCCCCCCCCCHHHHH	25.80	29255136
242	O-linked_Glycosylation	HKRPASVSSSAAVEH CCCCCCCCHHHHHHH	18.97	30059200
242	Phosphorylation	HKRPASVSSSAAVEH CCCCCCCCHHHHHHH	18.97	29255136
243	Phosphorylation	KRPASVSSSAAVEHE CCCCCCCHHHHHHHH	23.11	29255136
244	Phosphorylation	RPASVSSSAAVEHEQ CCCCCCHHHHHHHHH	16.85	30278072
272	Phosphorylation	AHRGPADSLSTAAGA CCCCCCCHHHHHHHH	26.73	28555341
274	Phosphorylation	RGPADSLSTAAGAAE CCCCCHHHHHHHHHH	21.69	21601212
275	Phosphorylation	GPADSLSTAAGAAEL CCCCHHHHHHHHHHH	26.31	23312004
283	Phosphorylation	AAGAAELSAEGAGKS HHHHHHHHHCCCCCC	18.77	23312004
289	Acetylation	LSAEGAGKSRGSGEQ HHHCCCCCCCCCCCC	36.12	25953088
289	Sumoylation	LSAEGAGKSRGSGEQ HHHCCCCCCCCCCCC	36.12	28112733
289	Ubiquitination	LSAEGAGKSRGSGEQ HHHCCCCCCCCCCCC	36.12	32015554
290	Phosphorylation	SAEGAGKSRGSGEQD HHCCCCCCCCCCCCC	40.74	25159151
291	Methylation	AEGAGKSRGSGEQDW HCCCCCCCCCCCCCC	46.94	115480511
293	Phosphorylation	GAGKSRGSGEQDWVN CCCCCCCCCCCCCCC	37.74	25159151
303	Sumoylation	QDWVNRPKTVRDTLL CCCCCCCHHHHHHHH	57.31	28112733
303	Ubiquitination	QDWVNRPKTVRDTLL CCCCCCCHHHHHHHH	57.31	29967540
308	Phosphorylation	RPKTVRDTLLALHQH CCHHHHHHHHHHHHH	17.07	22210691
318	Phosphorylation	ALHQHGHSGPFESKF HHHHHCCCCCCHHHC	53.40	23401153
323	Phosphorylation	GHSGPFESKFKKEPA CCCCCCHHHCCCCCC	43.71	23401153
324	Sumoylation	HSGPFESKFKKEPAL CCCCCHHHCCCCCCC	54.74	28112733
324	Ubiquitination	HSGPFESKFKKEPAL CCCCCHHHCCCCCCC	54.74	32015554
326	Sumoylation	GPFESKFKKEPALTA CCCHHHCCCCCCCCH	61.02	28112733
326	Ubiquitination	GPFESKFKKEPALTA CCCHHHCCCCCCCCH	61.02	29967540
327	Ubiquitination	PFESKFKKEPALTAG CCHHHCCCCCCCCHH	72.55	29967540
344	Phosphorylation	LGFEANGANGSKAVA HCCCCCCCCCHHHHH	19.61	32142685
344 (in isoform 2)	Phosphorylation	-	19.61	25849741
347	Phosphorylation	EANGANGSKAVARTA CCCCCCCHHHHHHHH	19.76	26074081
348	Acetylation	ANGANGSKAVARTAR CCCCCCHHHHHHHHH	48.56	25953088
348	Sumoylation	ANGANGSKAVARTAR CCCCCCHHHHHHHHH	48.56	28112733
348	Ubiquitination	ANGANGSKAVARTAR CCCCCCHHHHHHHHH	48.56	33845483
353	Phosphorylation	GSKAVARTARKRKPS CHHHHHHHHHHCCCC	22.52	26074081
360	Phosphorylation	TARKRKPSPEPEGEV HHHHCCCCCCCCCCC	44.95	29255136
380	Phosphorylation	NGEAQPWLSTSTEGL CCCCCCCCCCCCCCC	5.21	32142685
381	O-linked_Glycosylation	GEAQPWLSTSTEGLK CCCCCCCCCCCCCCC	19.22	30059200
381	Phosphorylation	GEAQPWLSTSTEGLK CCCCCCCCCCCCCCC	19.22	28450419
382	O-linked_Glycosylation	EAQPWLSTSTEGLKI CCCCCCCCCCCCCCC	37.18	30059200
382	Phosphorylation	EAQPWLSTSTEGLKI CCCCCCCCCCCCCCC	37.18	28450419
383	O-linked_Glycosylation	AQPWLSTSTEGLKIP CCCCCCCCCCCCCCC	22.53	30059200
383	Phosphorylation	AQPWLSTSTEGLKIP CCCCCCCCCCCCCCC	22.53	21815630
384	Phosphorylation	QPWLSTSTEGLKIPM CCCCCCCCCCCCCCC	33.87	28450419
392	O-linked_Glycosylation	EGLKIPMTPTSSFVS CCCCCCCCCCCCCCC	20.33	30059200
392	Phosphorylation	EGLKIPMTPTSSFVS CCCCCCCCCCCCCCC	20.33	23927012
394	Phosphorylation	LKIPMTPTSSFVSPP CCCCCCCCCCCCCCC	28.03	23927012
395	O-linked_Glycosylation	KIPMTPTSSFVSPPP CCCCCCCCCCCCCCC	24.00	30059200
395	Phosphorylation	KIPMTPTSSFVSPPP CCCCCCCCCCCCCCC	24.00	23927012
396	Phosphorylation	IPMTPTSSFVSPPPP CCCCCCCCCCCCCCC	31.95	30266825
399	Phosphorylation	TPTSSFVSPPPPTAS CCCCCCCCCCCCCCC	29.67	30266825
404	Phosphorylation	FVSPPPPTASPHSNR CCCCCCCCCCCCCCC	45.61	29255136
406	Phosphorylation	SPPPPTASPHSNRTT CCCCCCCCCCCCCCC	26.14	29255136
409	Phosphorylation	PPTASPHSNRTTPPE CCCCCCCCCCCCCHH	31.24	30266825
412	Phosphorylation	ASPHSNRTTPPEAAQ CCCCCCCCCCHHHHH	48.15	30278072
413	Phosphorylation	SPHSNRTTPPEAAQN CCCCCCCCCHHHHHC	33.34	30278072
423	Phosphorylation	EAAQNGQSPMAALIL HHHHCCCCCCEEEEE	20.31	23401153
438	Phosphorylation	VADNAGGSHASKDAN EEECCCCCCCCCCHH	18.24	23927012
441	Phosphorylation	NAGGSHASKDANQVH CCCCCCCCCCHHHHC	26.16	20068231
444	Phosphorylation	GSHASKDANQVHSTT CCCCCCCHHHHCCCC	16.46	32645325
446	Phosphorylation	HASKDANQVHSTTRR CCCCCHHHHCCCCCC	35.70	33259812
449	Phosphorylation	KDANQVHSTTRRNSN CCHHHHCCCCCCCCC	32.39	29514088
450	Phosphorylation	DANQVHSTTRRNSNS CHHHHCCCCCCCCCC	14.94	29514088
451	Phosphorylation	ANQVHSTTRRNSNSP HHHHCCCCCCCCCCC	30.55	29514088
455	Phosphorylation	HSTTRRNSNSPPSPS CCCCCCCCCCCCCCC	36.55	29255136
457	Phosphorylation	TTRRNSNSPPSPSSM CCCCCCCCCCCCCHH	37.70	29255136
460	Phosphorylation	RNSNSPPSPSSMNQR CCCCCCCCCCHHHCC	40.58	29255136
462	Phosphorylation	SNSPPSPSSMNQRRL CCCCCCCCHHHCCCC	46.70	29255136
463	Phosphorylation	NSPPSPSSMNQRRLG CCCCCCCHHHCCCCC	25.74	29255136
492	Phosphorylation	LEPVHPASLPDSSLA CCCCCCCCCCCCHHC	44.90	22817901
496	Phosphorylation	HPASLPDSSLATSAP CCCCCCCCHHCCCCC	25.88	22210691
497	Phosphorylation	PASLPDSSLATSAPL CCCCCCCHHCCCCCE	29.42	27080861
500	Phosphorylation	LPDSSLATSAPLCCT CCCCHHCCCCCEEHH	30.62	27080861
523	Neddylation	THFVQCPSVPSHKFC CCCCCCCCCCCCCCE	55.04	32015554
523	Ubiquitination	THFVQCPSVPSHKFC CCCCCCCCCCCCCCE	55.04	32015554
539	Neddylation	PCSRQSIKQQGASGE ECCHHHHHHCCCCCE	41.64	32015554
539	Ubiquitination	PCSRQSIKQQGASGE ECCHHHHHHCCCCCE	41.64	32015554
587	Phosphorylation	KVKKERDS------- EEECCCCC-------	48.63	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of I2BP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
360	S	Phosphorylation		17081983
Phosphorylation at Ser-360 is required for nuclear targeting.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of I2BP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRF2_HUMAN	IRF2	physical	12799427
NFAC2_HUMAN	NFATC2	physical	21576369
VGLL4_HUMAN	VGLL4	physical	20702774
IF4H_HUMAN	EIF4H	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of I2BP2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-455; SER-457; SER-460 AND SER-462, AND MASSSPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Identification of a phosphorylation-dependent nuclear localizationmotif in interferon regulatory factor 2 binding protein 2."; Teng A.C., Al-Montashiri N.A., Cheng B.L., Lou P., Ozmizrak P.,Chen H.H., Stewart A.F.; PLoS ONE 6:E24100-E24100(2011). Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, AND PHOSPHORYLATIONAT SER-360.	21887377 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360; THR-392 ANDSER-457, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-455; SER-457; SER-460 AND SER-462, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175; SER-360; SER-455;SER-457 AND SER-460, AND MASS SPECTROMETRY.	18669648 [Abstract]

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