CAND2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAND2_MOUSE
• UniProt AC: Q6ZQ73
• Protein Name: Cullin-associated NEDD8-dissociated protein 2
• Gene Name: Cand2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1235
• Subcellular Localization: Nucleus.
• Protein Description: Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes..
• Protein Sequence: MSTGAFYISSLLEKMTSSDKDFRFMATSDLMSELQKDSIQLDEDSERKVVRTLLRLLEDRSGEVQNLAVKCLGPLVGKVKEYQVENIVDTLCANMRSDKEQLRDIAGIGLKTVLSELPPAATGSGLAINVCRKITGQLTSAIAQQEDVAVQLEALDILSDMLSRLGAPLGTFHASLLHCLLPQLSSPRLAVRKRTVVALGHLAAACSTDLFVELADHLVDRLPGPRAPASPAAIRTLIQCLGSVGRQAGHRLGAHLDRLVPMVEEFCNLDDDELRESCLQAFEAFLRKCPKEMDPHVPNVTSLCLQYMKHDPNYDHDSDDEEQMETEDSEFSEQESEDEYSDDDDMSWKVRRAAAKCMAALISSRPDLLPDFHCTLAPALIRRFKEREENVKADIFGAYIMLLRHTRPPKGWLEAVEEPTQTGRNLNMLRAQVPLVIKALQRQLKDRNVRTRQGCFNLFTELAGVLPGSLAEHMAVLVSGIVFSLADYSSSSTIRMDALAFLQGLLGTEPAEAFHPHLPTLLPPVMACVADPFYKVAAEALLVLQELVRTLWPLDRPRLLDPEPYVGEMSTATLARLRATDLDQEVKERAISCVGHLVGHLGDRLGDDLEPTLMLLLDRLRNEITRLPAVKALTLVAMSPLRLDLQPILAEALPILASFLRKNQRALRLATLAALDALAQSQGLGLPPPAVRTVLTELPALVSENDMHVAQLAVDFLTTVTQTQPSSLVEVSGPVLGELLQLLHSPLLPAGVLAATEGFLQALVGTRPPCVEYSELISLLTAPVYNQVGDGGPGLHKQVFHSLARCVAALSAACPQEAAGTASRLVCDAKSPHSSTGVKVLAFLSLAEVGQVAGPGPQRELKTVLLEALGSPSEDVRAAAAYALGRVGAGNLPDFLPFLLAQIEAQPRRQYLLLHALREALGAAQPDNLKPYVEDVWALLFQRCESPEEGTRCVVAECIGKLVFVNPPYLLPRFRKQLAAGQPYTRSTVITAVKFLISDQPHSIDPLLKSFIAEFMESLQDPDLNVRRATLTFFNSAVHNKPSLVRDLLDDILPLLYQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMYSLLESCLGQLDMCEFLNHVEDGLKDHYDIRMLTFIMLARLATLCPAPVLQRVDRLIEPLRATCTAKVKAGSVKQELEKQEELKRSAMRAVAALLTNPEVRKSPTVADFSAQIRSNPELTTLFESIQKDTASGPSTDSMELS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTGAFYIS ------CCCHHHHHH	47.02	-
2	Phosphorylation	------MSTGAFYIS ------CCCHHHHHH	47.02	25338131
3	Phosphorylation	-----MSTGAFYISS -----CCCHHHHHHH	44.37	25338131
90	Phosphorylation	QVENIVDTLCANMRS HHHHHHHHHHHHCCC	16.91	25338131
99	Ubiquitination	CANMRSDKEQLRDIA HHHCCCCHHHHHHHH	48.91	22790023
115	Phosphorylation	IGLKTVLSELPPAAT CCHHHHHHHCCCCCC	32.52	21454597
230	Phosphorylation	PGPRAPASPAAIRTL CCCCCCCCHHHHHHH	17.64	28066266
240	S-nitrosocysteine	AIRTLIQCLGSVGRQ HHHHHHHHHHHHHHH	3.54	-
240	S-nitrosylation	AIRTLIQCLGSVGRQ HHHHHHHHHHHHHHH	3.54	21278135
438	Ubiquitination	AQVPLVIKALQRQLK HHHHHHHHHHHHHHH	35.25	22790023
587	Ubiquitination	TDLDQEVKERAISCV CCCCHHHHHHHHHHH	40.50	22790023
976	Ubiquitination	YLLPRFRKQLAAGQP CHHHHHHHHHHCCCC	47.13	22790023
1195	Ubiquitination	LTNPEVRKSPTVADF HHCHHHHCCCCHHHH	67.00	22790023
1196	Phosphorylation	TNPEVRKSPTVADFS HCHHHHCCCCHHHHH	18.42	26370283
1225	Phosphorylation	SIQKDTASGPSTDSM HHHHCCCCCCCCCCC	54.02	27742792
1229	Phosphorylation	DTASGPSTDSMELS- CCCCCCCCCCCCCC-	34.92	29514104
1231	Phosphorylation	ASGPSTDSMELS--- CCCCCCCCCCCC---	17.78	28464351
1235	Phosphorylation	STDSMELS------- CCCCCCCC-------	25.52	28464351

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAND2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAND2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAND2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_MOUSE	Cul1	physical	17242400

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.