NUP54_HUMAN - dbPTM
NUP54_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NUP54_HUMAN
UniProt AC Q7Z3B4
Protein Name Nucleoporin p54
Gene Name NUP54
Organism Homo sapiens (Human).
Sequence Length 507
Subcellular Localization Nucleus, nuclear pore complex . Nucleus membrane
Peripheral membrane protein
Cytoplasmic side . Nucleus membrane
Peripheral membrane protein
Nucleoplasmic side . Biased towards cytoplasmic side. Central region of the nuclear pore complex, wit
Protein Description Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane..
Protein Sequence MAFNFGAPSGTSGTAAATAAPAGGFGGFGTTSTTAGSAFSFSAPTNTGTTGLFGGTQNKGFGFGTGFGTTTGTSTGLGTGLGTGLGFGGFNTQQQQQTTLGGLFSQPTQAPTQSNQLINTASALSAPTLLGDERDAILAKWNQLQAFWGTGKGYFNNNIPPVEFTQENPFCRFKAVGYSCMPSNKDEDGLVVLVFNKKETEIRSQQQQLVESLHKVLGGNQTLTVNVEGTKTLPDDQTEVVIYVVERSPNGTSRRVPATTLYAHFEQANIKTQLQQLGVTLSMTRTELSPAQIKQLLQNPPAGVDPIIWEQAKVDNPDSEKLIPVPMVGFKELLRRLKVQDQMTKQHQTRLDIISEDISELQKNQTTSVAKIAQYKRKLMDLSHRTLQVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGRLNELMSQIRMQNHFGAVRSEERYYIDADLLREIKQHLKQQQEGLSHLISIIKDDLEDIKLVEHGLNETIHIRGGVFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9O-linked_GlycosylationAFNFGAPSGTSGTAA
CCCCCCCCCCCCCHH		54.9223301498
30O-linked_GlycosylationGGFGGFGTTSTTAGS
CCCCCCCCCCCCCCC		18.4723301498
31O-linked_GlycosylationGFGGFGTTSTTAGSA
CCCCCCCCCCCCCCC		25.1823301498
32O-linked_GlycosylationFGGFGTTSTTAGSAF
CCCCCCCCCCCCCCE		24.4923301498
33O-linked_GlycosylationGGFGTTSTTAGSAFS
CCCCCCCCCCCCCEE		20.6923301498
34O-linked_GlycosylationGFGTTSTTAGSAFSF
CCCCCCCCCCCCEEE		28.8723301498
37O-linked_GlycosylationTTSTTAGSAFSFSAP
CCCCCCCCCEEEECC		24.5523301498
45O-linked_GlycosylationAFSFSAPTNTGTTGL
CEEEECCCCCCCCCC		45.1623301498
92UbiquitinationLGFGGFNTQQQQQTT
CCCCCCCHHHHHCCC		26.03-
114UbiquitinationPTQAPTQSNQLINTA
CCCCCCCCCCCCHHH		29.0823503661
114 (in isoform 2)Ubiquitination-29.0821890473
133 (in isoform 2)Ubiquitination-51.1421890473
140UbiquitinationERDAILAKWNQLQAF
HHHHHHHHHHHHHHH		43.1421906983
141 (in isoform 2)Ubiquitination-7.6921890473
158UbiquitinationGKGYFNNNIPPVEFT
CCCCCCCCCCCCEEC		49.6124816145
158 (in isoform 2)Ubiquitination-49.6121890473
165UbiquitinationNIPPVEFTQENPFCR
CCCCCEECCCCCCCE		22.8217623298
165 (in isoform 2)Ubiquitination-22.8221890473
167UbiquitinationPPVEFTQENPFCRFK
CCCEECCCCCCCEEE		64.9129967540
178PhosphorylationCRFKAVGYSCMPSNK
CEEEEEEEECCCCCC		7.6627642862
179PhosphorylationRFKAVGYSCMPSNKD
EEEEEEEECCCCCCC		9.6727642862
182 (in isoform 2)Ubiquitination-38.7921890473
183PhosphorylationVGYSCMPSNKDEDGL
EEEECCCCCCCCCCE		29.6327642862
185AcetylationYSCMPSNKDEDGLVV
EECCCCCCCCCCEEE		67.8226051181
196UbiquitinationGLVVLVFNKKETEIR
CEEEEEEECCHHHHH		47.1927667366
1972-HydroxyisobutyrylationLVVLVFNKKETEIRS
EEEEEEECCHHHHHH		40.29-
197AcetylationLVVLVFNKKETEIRS
EEEEEEECCHHHHHH		40.2926051181
204PhosphorylationKKETEIRSQQQQLVE
CCHHHHHHHHHHHHH		37.69-
212 (in isoform 2)Ubiquitination-28.4421890473
215UbiquitinationQLVESLHKVLGGNQT
HHHHHHHHHHCCCCE		44.4429967540
218UbiquitinationESLHKVLGGNQTLTV
HHHHHHHCCCCEEEE		35.6724816145
222PhosphorylationKVLGGNQTLTVNVEG
HHHCCCCEEEEEEEE		28.5320068231
232PhosphorylationVNVEGTKTLPDDQTE
EEEEECEECCCCCCE		43.2828509920
246UbiquitinationEVVIYVVERSPNGTS
EEEEEEEEECCCCCC		37.0823503661
246UbiquitinationEVVIYVVERSPNGTS
EEEEEEEEECCCCCC		37.08-
248UbiquitinationVIYVVERSPNGTSRR
EEEEEEECCCCCCCC		14.8223000965
262PhosphorylationRVPATTLYAHFEQAN
CCCCCHHHHHHHHCC		8.9229496907
265UbiquitinationATTLYAHFEQANIKT
CCHHHHHHHHCCHHH		5.91-
265UbiquitinationATTLYAHFEQANIKT
CCHHHHHHHHCCHHH		5.9129967540
273UbiquitinationEQANIKTQLQQLGVT
HHCCHHHHHHHHCCE		32.07-
282PhosphorylationQQLGVTLSMTRTELS
HHHCCEEEECCCCCC		14.5618452278
283UbiquitinationQLGVTLSMTRTELSP
HHCCEEEECCCCCCH		3.10-
284PhosphorylationLGVTLSMTRTELSPA
HCCEEEECCCCCCHH		30.9418452278
286PhosphorylationVTLSMTRTELSPAQI
CEEEECCCCCCHHHH		31.9230266825
289PhosphorylationSMTRTELSPAQIKQL
EECCCCCCHHHHHHH		16.3830266825
290UbiquitinationMTRTELSPAQIKQLL
ECCCCCCHHHHHHHH		40.5921890473
290UbiquitinationMTRTELSPAQIKQLL
ECCCCCCHHHHHHHH		40.5929967540
294UbiquitinationELSPAQIKQLLQNPP
CCCHHHHHHHHHCCC		23.8621906983
297UbiquitinationPAQIKQLLQNPPAGV
HHHHHHHHHCCCCCC		4.2421890473
297UbiquitinationPAQIKQLLQNPPAGV
HHHHHHHHHCCCCCC		4.2429967540
313UbiquitinationPIIWEQAKVDNPDSE
CHHHEECCCCCCCCC		50.2221906983
315UbiquitinationIWEQAKVDNPDSEKL
HHEECCCCCCCCCCC		61.3029967540
315UbiquitinationIWEQAKVDNPDSEKL
HHEECCCCCCCCCCC		61.3021890473
319PhosphorylationAKVDNPDSEKLIPVP
CCCCCCCCCCCCCCC		37.58-
321AcetylationVDNPDSEKLIPVPMV
CCCCCCCCCCCCCCC		56.5225953088
321UbiquitinationVDNPDSEKLIPVPMV
CCCCCCCCCCCCCCC		56.5221906983
323UbiquitinationNPDSEKLIPVPMVGF
CCCCCCCCCCCCCCH		4.8429967540
323UbiquitinationNPDSEKLIPVPMVGF
CCCCCCCCCCCCCCH		4.84-
328UbiquitinationKLIPVPMVGFKELLR
CCCCCCCCCHHHHHH		7.1627667366
331UbiquitinationPVPMVGFKELLRRLK
CCCCCCHHHHHHHHH		41.33-
338UbiquitinationKELLRRLKVQDQMTK
HHHHHHHHHHHHHHH		35.7221906983
345UbiquitinationKVQDQMTKQHQTRLD
HHHHHHHHHHHHHHH		40.2021906983
349PhosphorylationQMTKQHQTRLDIISE
HHHHHHHHHHHHHHH		30.9530177828
350UbiquitinationMTKQHQTRLDIISED
HHHHHHHHHHHHHHH		24.6421890473
350UbiquitinationMTKQHQTRLDIISED
HHHHHHHHHHHHHHH		24.6429967540
355PhosphorylationQTRLDIISEDISELQ
HHHHHHHHHHHHHHH		29.5628122231
359PhosphorylationDIISEDISELQKNQT
HHHHHHHHHHHHCCC		44.5728122231
362UbiquitinationSEDISELQKNQTTSV
HHHHHHHHHCCCCHH		38.3024816145
363UbiquitinationEDISELQKNQTTSVA
HHHHHHHHCCCCHHH		64.7421906983
371UbiquitinationNQTTSVAKIAQYKRK
CCCCHHHHHHHHHHH		36.1029967540
376UbiquitinationVAKIAQYKRKLMDLS
HHHHHHHHHHHHCCC		30.8627667366
380UbiquitinationAQYKRKLMDLSHRTL
HHHHHHHHCCCHHHH		5.6723000965
380UbiquitinationAQYKRKLMDLSHRTL
HHHHHHHHCCCHHHH		5.67-
392UbiquitinationRTLQVLIKQEIQRKS
HHHHHHHHHHHHHHC		37.4023000965
398UbiquitinationIKQEIQRKSGYAIQA
HHHHHHHHCCCEEEC		31.6821906983
3982-HydroxyisobutyrylationIKQEIQRKSGYAIQA
HHHHHHHHCCCEEEC		31.68-
399PhosphorylationKQEIQRKSGYAIQAD
HHHHHHHCCCEEECC		38.9428152594
401PhosphorylationEIQRKSGYAIQADEE
HHHHHCCCEEECCHH		13.9728152594
416PhosphorylationQLRVQLDTIQGELNA
HHHHHHHHHCCCCCC		24.6420068231
420UbiquitinationQLDTIQGELNAPTQF
HHHHHCCCCCCCHHH		23.6029967540
425PhosphorylationQGELNAPTQFKGRLN
CCCCCCCHHHHHHHH		44.2020068231
428 (in isoform 1)Ubiquitination-33.0521890473
428UbiquitinationLNAPTQFKGRLNELM
CCCCHHHHHHHHHHH		33.0523000965
428AcetylationLNAPTQFKGRLNELM
CCCCHHHHHHHHHHH		33.0526051181
430MethylationAPTQFKGRLNELMSQ
CCHHHHHHHHHHHHH		34.62115485877
439MethylationNELMSQIRMQNHFGA
HHHHHHHHHHHCCCC		17.01115485871
441UbiquitinationLMSQIRMQNHFGAVR
HHHHHHHHHCCCCCC		30.3329967540
453PhosphorylationAVRSEERYYIDADLL
CCCCCCCEEECHHHH		14.1927642862
454PhosphorylationVRSEERYYIDADLLR
CCCCCCEEECHHHHH		9.8829978859
468UbiquitinationREIKQHLKQQQEGLS
HHHHHHHHHHHHHHH		43.8929967540
475PhosphorylationKQQQEGLSHLISIIK
HHHHHHHHHHHHHHH		27.4021406692
479PhosphorylationEGLSHLISIIKDDLE
HHHHHHHHHHHHCHH		25.3124719451
489UbiquitinationKDDLEDIKLVEHGLN
HHCHHHCHHHHCCCC		59.8229967540
498PhosphorylationVEHGLNETIHIRGGV
HHCCCCCCEEECCCC		19.4428555341
507PhosphorylationHIRGGVFS-------
EECCCCCC-------		36.5826074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NUP54_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NUP54_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NUP54_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NTF2_HUMANNUTF2physical
8707840
IMA5_HUMANKPNA1physical
8707840
IFT20_HUMANIFT20physical
25416956
HAUS1_HUMANHAUS1physical
25416956
NUP98_HUMANNUP98physical
26344197
RAE1L_HUMANRAE1physical
26344197
NUP58_HUMANNUPL1physical
28514442
N62CL_HUMANNUP62CLphysical
28514442
BFSP1_HUMANBFSP1physical
28514442
NUP62_HUMANNUP62physical
28514442
CP250_HUMANCEP250physical
28514442
LPXN_HUMANLPXNphysical
28514442
HOME1_HUMANHOMER1physical
28514442
NDE1_HUMANNDE1physical
28514442
CDK16_HUMANCDK16physical
28514442
COG4_HUMANCOG4physical
28514442
WDR59_HUMANWDR59physical
28514442
HOME3_HUMANHOMER3physical
28514442
EXOC1_HUMANEXOC1physical
28514442
CRNN_HUMANCRNNphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NUP54_HUMAN

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Related Literatures of Post-Translational Modification

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