| UniProt ID | RAE1L_HUMAN | |
|---|---|---|
| UniProt AC | P78406 | |
| Protein Name | mRNA export factor | |
| Gene Name | RAE1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 368 | |
| Subcellular Localization | Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle pole . Recruited from interphase nuclei to spindle MTs during mitosis. | |
| Protein Description | Plays a role in mitotic bipolar spindle formation. [PubMed: 17172455 Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.] | |
| Protein Sequence | MSLFGTTSGFGTSGTSMFGSATTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAEELKPRNKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLFGTTSG ------CCCCCCCCC | 32.19 | 27050516 | |
| 6 | Phosphorylation | --MSLFGTTSGFGTS --CCCCCCCCCCCCC | 15.51 | 25693802 | |
| 7 | Phosphorylation | -MSLFGTTSGFGTSG -CCCCCCCCCCCCCC | 27.51 | 25693802 | |
| 8 | Phosphorylation | MSLFGTTSGFGTSGT CCCCCCCCCCCCCCC | 31.78 | 25693802 | |
| 12 | Phosphorylation | GTTSGFGTSGTSMFG CCCCCCCCCCCCCCC | 23.01 | 25693802 | |
| 13 | Phosphorylation | TTSGFGTSGTSMFGS CCCCCCCCCCCCCCC | 40.22 | 25693802 | |
| 15 | Phosphorylation | SGFGTSGTSMFGSAT CCCCCCCCCCCCCCC | 19.45 | 25693802 | |
| 16 | Phosphorylation | GFGTSGTSMFGSATT CCCCCCCCCCCCCCC | 18.68 | 25693802 | |
| 20 | Phosphorylation | SGTSMFGSATTDNHN CCCCCCCCCCCCCCC | 15.92 | 25693802 | |
| 22 | Phosphorylation | TSMFGSATTDNHNPM CCCCCCCCCCCCCCC | 36.06 | 25693802 | |
| 23 | Phosphorylation | SMFGSATTDNHNPMK CCCCCCCCCCCCCCC | 34.22 | 25693802 | |
| 80 | Ubiquitination | DSGQTIPKAQQMHTG CCCCCCCHHHHCCCC | 55.78 | - | |
| 100 | Ubiquitination | CWSDDGSKVFTASCD EECCCCCEEEEEECC | 47.07 | 29967540 | |
| 108 | Ubiquitination | VFTASCDKTAKMWDL EEEEECCCCCCEECC | 55.50 | 22817900 | |
| 108 | Acetylation | VFTASCDKTAKMWDL EEEEECCCCCCEECC | 55.50 | 23749302 | |
| 108 | 2-Hydroxyisobutyrylation | VFTASCDKTAKMWDL EEEEECCCCCCEECC | 55.50 | - | |
| 111 | Acetylation | ASCDKTAKMWDLSSN EECCCCCCEECCCCC | 45.84 | 25953088 | |
| 111 | Ubiquitination | ASCDKTAKMWDLSSN EECCCCCCEECCCCC | 45.84 | 21906983 | |
| 116 | Phosphorylation | TAKMWDLSSNQAIQI CCCEECCCCCCHHHH | 25.44 | 30622161 | |
| 117 | Phosphorylation | AKMWDLSSNQAIQIA CCEECCCCCCHHHHH | 40.01 | 30622161 | |
| 131 | Acetylation | AQHDAPVKTIHWIKA HCCCCCCEEEEEEEC | 40.48 | 23954790 | |
| 131 | Ubiquitination | AQHDAPVKTIHWIKA HCCCCCCEEEEEEEC | 40.48 | 29967540 | |
| 137 | Acetylation | VKTIHWIKAPNYSCV CEEEEEEECCCCEEE | 53.23 | 25953088 | |
| 142 | Phosphorylation | WIKAPNYSCVMTGSW EEECCCCEEEEECCC | 13.58 | 20068231 | |
| 146 | Ubiquitination | PNYSCVMTGSWDKTL CCCEEEEECCCCCEE | 13.99 | 22817900 | |
| 146 | Phosphorylation | PNYSCVMTGSWDKTL CCCEEEEECCCCCEE | 13.99 | 20068231 | |
| 148 | Phosphorylation | YSCVMTGSWDKTLKF CEEEEECCCCCEEEE | 23.96 | 20068231 | |
| 149 | Ubiquitination | SCVMTGSWDKTLKFW EEEEECCCCCEEEEE | 16.68 | 22817900 | |
| 151 | Acetylation | VMTGSWDKTLKFWDT EEECCCCCEEEEEEC | 49.88 | 26051181 | |
| 151 | Ubiquitination | VMTGSWDKTLKFWDT EEECCCCCEEEEEEC | 49.88 | 22817900 | |
| 154 | Acetylation | GSWDKTLKFWDTRSS CCCCCEEEEEECCCC | 50.03 | 26051181 | |
| 154 | 2-Hydroxyisobutyrylation | GSWDKTLKFWDTRSS CCCCCEEEEEECCCC | 50.03 | - | |
| 154 | Ubiquitination | GSWDKTLKFWDTRSS CCCCCEEEEEECCCC | 50.03 | 21906983 | |
| 154 | Ubiquitination | GSWDKTLKFWDTRSS CCCCCEEEEEECCCC | 50.03 | 21890473 | |
| 160 | Phosphorylation | LKFWDTRSSNPMMVL EEEEECCCCCCEEEE | 36.24 | 25693802 | |
| 161 | Phosphorylation | KFWDTRSSNPMMVLQ EEEECCCCCCEEEEE | 41.48 | 28634298 | |
| 174 | Phosphorylation | LQLPERCYCADVIYP EECCCCEEECCCCCE | 9.26 | 28634298 | |
| 180 | Phosphorylation | CYCADVIYPMAVVAT EEECCCCCEEEEEEE | 6.18 | 20090780 | |
| 187 | Phosphorylation | YPMAVVATAERGLIV CEEEEEEECCCCEEE | 19.90 | 28634298 | |
| 189 | Ubiquitination | MAVVATAERGLIVYQ EEEEEECCCCEEEEE | 42.82 | 22817900 | |
| 192 | Ubiquitination | VATAERGLIVYQLEN EEECCCCEEEEEECC | 2.76 | 21890473 | |
| 209 | Phosphorylation | SEFRRIESPLKHQHR HHHHCCCCCCCCCCE | 32.91 | 30266825 | |
| 212 | Ubiquitination | RRIESPLKHQHRCVA HCCCCCCCCCCEEEE | 44.60 | 33845483 | |
| 212 | Methylation | RRIESPLKHQHRCVA HCCCCCCCCCCEEEE | 44.60 | 82987339 | |
| 222 | Ubiquitination | HRCVAIFKDKQNKPT CEEEEEEECCCCCCC | 58.88 | 22817900 | |
| 224 | Ubiquitination | CVAIFKDKQNKPTGF EEEEEECCCCCCCCE | 57.26 | 22817900 | |
| 227 | Ubiquitination | IFKDKQNKPTGFALG EEECCCCCCCCEEEE | 41.27 | 21906983 | |
| 229 | Phosphorylation | KDKQNKPTGFALGSI ECCCCCCCCEEEEEE | 46.68 | 20068231 | |
| 235 | Phosphorylation | PTGFALGSIEGRVAI CCCEEEEEEEEEEEE | 20.51 | 20068231 | |
| 250 | Ubiquitination | HYINPPNPAKDNFTF EEECCCCCCCCCEEE | 46.60 | 27667366 | |
| 252 | Ubiquitination | INPPNPAKDNFTFKC ECCCCCCCCCEEEEE | 55.23 | 23000965 | |
| 252 | Acetylation | INPPNPAKDNFTFKC ECCCCCCCCCEEEEE | 55.23 | 23749302 | |
| 258 | Ubiquitination | AKDNFTFKCHRSNGT CCCCEEEEEECCCCC | 26.52 | 23000965 | |
| 258 | Methylation | AKDNFTFKCHRSNGT CCCCEEEEEECCCCC | 26.52 | 82987345 | |
| 258 | Acetylation | AKDNFTFKCHRSNGT CCCCEEEEEECCCCC | 26.52 | 25953088 | |
| 258 | Malonylation | AKDNFTFKCHRSNGT CCCCEEEEEECCCCC | 26.52 | 26320211 | |
| 260 | Ubiquitination | DNFTFKCHRSNGTNT CCEEEEEECCCCCCC | 36.47 | 22817900 | |
| 262 | Ubiquitination | FTFKCHRSNGTNTSA EEEEEECCCCCCCCC | 18.88 | 22817900 | |
| 265 | Ubiquitination | KCHRSNGTNTSAPQD EEECCCCCCCCCCCE | 39.30 | 22817900 | |
| 274 | Phosphorylation | TSAPQDIYAVNGIAF CCCCCEEEEECCEEE | 16.88 | 22817900 | |
| 290 | Ubiquitination | PVHGTLATVGSDGRF CCCCCEEEECCCCCE | 28.63 | 23000965 | |
| 296 | Ubiquitination | ATVGSDGRFSFWDKD EEECCCCCEECCCCC | 29.09 | 23000965 | |
| 302 | Ubiquitination | GRFSFWDKDARTKLK CCEECCCCCHHHHCC | 43.83 | 22817900 | |
| 302 | Acetylation | GRFSFWDKDARTKLK CCEECCCCCHHHHCC | 43.83 | 26051181 | |
| 307 | Ubiquitination | WDKDARTKLKTSEQL CCCCHHHHCCCHHHC | 42.29 | 22817900 | |
| 309 | Ubiquitination | KDARTKLKTSEQLDQ CCHHHHCCCHHHCCC | 52.11 | 21963094 | |
| 340 | Ubiquitination | ASSYDWSKGHEFYNP EEECCCCCCCCCCCC | 61.09 | 22817900 | |
| 345 | Ubiquitination | WSKGHEFYNPQKKNY CCCCCCCCCCCCCCE | 23.97 | 22817900 | |
| 345 | Phosphorylation | WSKGHEFYNPQKKNY CCCCCCCCCCCCCCE | 23.97 | 25159151 | |
| 347 | Ubiquitination | KGHEFYNPQKKNYIF CCCCCCCCCCCCEEE | 35.67 | 21963094 | |
| 349 | 2-Hydroxyisobutyrylation | HEFYNPQKKNYIFLR CCCCCCCCCCEEEEC | 44.22 | - | |
| 349 | Ubiquitination | HEFYNPQKKNYIFLR CCCCCCCCCCEEEEC | 44.22 | 33845483 | |
| 350 | Ubiquitination | EFYNPQKKNYIFLRN CCCCCCCCCEEEECC | 50.14 | 29967540 | |
| 350 | Acetylation | EFYNPQKKNYIFLRN CCCCCCCCCEEEECC | 50.14 | 26051181 | |
| 352 | Phosphorylation | YNPQKKNYIFLRNAA CCCCCCCEEEECCHH | 11.26 | 27642862 | |
| 356 | Methylation | KKNYIFLRNAAEELK CCCEEEECCHHHHHC | 21.71 | 115490167 | |
| 363 | Acetylation | RNAAEELKPRNKK-- CCHHHHHCCCCCC-- | 45.25 | 25953088 | |
| 363 | Ubiquitination | RNAAEELKPRNKK-- CCHHHHHCCCCCC-- | 45.25 | 32015554 | |
| 387 | Ubiquitination | -------------------------- -------------------------- | 27667366 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RAE1L_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RAE1L_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RAE1L_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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