ADPPT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADPPT_HUMAN
• UniProt AC: Q9NRN7
• Protein Name: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
• Gene Name: AASDHPPT
• Organism: Homo sapiens (Human).
• Sequence Length: 309
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN..
• Protein Sequence: MVFPAKRFCLVPSMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGLGFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEWAFEESKIDEHHFVAVALRKPDGSRHQDVPSQDDSKPTQRQFTILNFNDLMSSAVPMTPEDPSFWDCFCFTEEIPIRNGTKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Ubiquitination	RSIQPEEKERIGQFV HHCCHHHHHHHHHEE	51.10	-
45	Ubiquitination	RSIQPEEKERIGQFV HHCCHHHHHHHHHEE	51.10	24816145
58	Acetylation	FVFARDAKAAMAGRL EEHHHHHHHHHHHHH	40.75	12436925
58	Ubiquitination	FVFARDAKAAMAGRL EEHHHHHHHHHHHHH	40.75	27667366
58	Ubiquitination	FVFARDAKAAMAGRL EEHHHHHHHHHHHHH	40.75	-
74	Ubiquitination	IRKLVAEKLNIPWNH HHHHHHHHCCCCCHH	36.78	29967540
74	Ubiquitination	IRKLVAEKLNIPWNH HHHHHHHHCCCCCHH	36.78	-
89	Ubiquitination	IRLQRTAKGKPVLAK HEEEEECCCCCCEEC	67.84	29967540
89	Acetylation	IRLQRTAKGKPVLAK HEEEEECCCCCCEEC	67.84	11924561
149	Ubiquitination	PEFFHIMKRKFTNKE HHHHHHHHHHCCCCC	52.40	21890473
149	Ubiquitination	PEFFHIMKRKFTNKE HHHHHHHHHHCCCCC	52.40	21906983
149	Acetylation	PEFFHIMKRKFTNKE HHHHHHHHHHCCCCC	52.40	23749302
151	Acetylation	FFHIMKRKFTNKEWE HHHHHHHHCCCCCCH	51.53	23749302
151	Malonylation	FFHIMKRKFTNKEWE HHHHHHHHCCCCCCH	51.53	26320211
151	Ubiquitination	FFHIMKRKFTNKEWE HHHHHHHHCCCCCCH	51.53	22817900
155	Ubiquitination	MKRKFTNKEWETIRS HHHHCCCCCCHHHHH	62.23	27667366
161	Methylation	NKEWETIRSFKDEWT CCCCHHHHHHHHHHH	43.38	-
164	Ubiquitination	WETIRSFKDEWTQLD CHHHHHHHHHHHHHH	56.86	21890473
164	Acetylation	WETIRSFKDEWTQLD CHHHHHHHHHHHHHH	56.86	26051181
164	Ubiquitination	WETIRSFKDEWTQLD CHHHHHHHHHHHHHH	56.86	21906983
168	Phosphorylation	RSFKDEWTQLDMFYR HHHHHHHHHHHHHHH	19.73	20068231
174	Phosphorylation	WTQLDMFYRNWALKE HHHHHHHHHCHHHHH	9.08	20068231
180	Ubiquitination	FYRNWALKESFIKAI HHHCHHHHHHHHHHH	43.49	23503661
182	Phosphorylation	RNWALKESFIKAIGV HCHHHHHHHHHHHCC	30.59	24719451
185	Ubiquitination	ALKESFIKAIGVGLG HHHHHHHHHHCCCCC	31.76	23503661
214	Ubiquitination	LDIGQVYKETRLFLD CCHHHHHEEEEEEEC	54.47	21906983
226	Ubiquitination	FLDGEEEKEWAFEES EECCHHHHHHCCCHH	62.93	29967540
233	Phosphorylation	KEWAFEESKIDEHHF HHHCCCHHCCCCCCE	27.93	20068231
251	Phosphorylation	ALRKPDGSRHQDVPS EEECCCCCCCCCCCC	33.69	28555341
258	Phosphorylation	SRHQDVPSQDDSKPT CCCCCCCCCCCCCCC	46.20	17525332
262	Phosphorylation	DVPSQDDSKPTQRQF CCCCCCCCCCCCCEE	49.15	28450419
263	Ubiquitination	VPSQDDSKPTQRQFT CCCCCCCCCCCCEEE	60.11	27667366
265	Phosphorylation	SQDDSKPTQRQFTIL CCCCCCCCCCEEEEE	39.87	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADPPT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADPPT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADPPT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EHD1_HUMAN	EHD1	physical	22863883
EHD4_HUMAN	EHD4	physical	22863883
HNRH1_HUMAN	HNRNPH1	physical	22863883
NOL3_HUMAN	NOL3	physical	22863883
PLCG1_HUMAN	PLCG1	physical	22863883
NIPA_HUMAN	ZC3HC1	physical	22863883
STIL_HUMAN	STIL	physical	26186194
POTEI_HUMAN	POTEI	physical	26186194
UBP22_HUMAN	USP22	physical	26186194
TPPC4_HUMAN	TRAPPC4	physical	26344197
UBP22_HUMAN	USP22	physical	28514442
POTEI_HUMAN	POTEI	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258, AND MASSSPECTROMETRY.
PubMed: 18669648

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258, AND MASSSPECTROMETRY.
PubMed: 17525332