RPC8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPC8_HUMAN
• UniProt AC: Q9Y535
• Protein Name: DNA-directed RNA polymerase III subunit RPC8
• Gene Name: POLR3H
• Organism: Homo sapiens (Human).
• Sequence Length: 204
• Subcellular Localization: Nucleus.
• Protein Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity)..
• Protein Sequence: MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKKEAPYTLVGSISEPGLGLLSWWTSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Ubiquitination	PPWQFERKLNDSIAE CHHHHHHHHCHHHHH	44.43	-
32	Ubiquitination	SIAEELNKKLANKVV HHHHHHHHHHHHHHH	62.88	-
32	Acetylation	SIAEELNKKLANKVV HHHHHHHHHHHHHHH	62.88	23236377
90	Ubiquitination	EILIGKIKGCSPEGV HHHHHCCCCCCCCCE	58.30	-
156	Phosphorylation	RFRVVDESFVDTSPT EEEEECHHHCCCCCC	26.55	28555341
160	Phosphorylation	VDESFVDTSPTGPSS ECHHHCCCCCCCCCC	31.16	29978859
161	Phosphorylation	DESFVDTSPTGPSSA CHHHCCCCCCCCCCC	18.92	29978859
163	Phosphorylation	SFVDTSPTGPSSADA HHCCCCCCCCCCCCC	62.58	29978859
166	Phosphorylation	DTSPTGPSSADATTS CCCCCCCCCCCCCCC	39.23	29978859
167	Phosphorylation	TSPTGPSSADATTSS CCCCCCCCCCCCCCC	33.05	29978859
171	Phosphorylation	GPSSADATTSSEELP CCCCCCCCCCCCCCC	27.97	29978859
172	Phosphorylation	PSSADATTSSEELPK CCCCCCCCCCCCCCC	31.79	29978859
173	Phosphorylation	SSADATTSSEELPKK CCCCCCCCCCCCCCC	31.25	29978859
174	Phosphorylation	SADATTSSEELPKKE CCCCCCCCCCCCCCC	32.76	29978859
179	Ubiquitination	TSSEELPKKEAPYTL CCCCCCCCCCCCEEE	75.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPC8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPC8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPC8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPC2_HUMAN	POLR3B	physical	17643375
RPC4_HUMAN	POLR3D	physical	17643375
RPC3_HUMAN	POLR3C	physical	17643375
RPC5_HUMAN	POLR3E	physical	17643375
RPC1_HUMAN	POLR3A	physical	17643375
RPAB3_HUMAN	POLR2H	physical	17643375
RPC7_HUMAN	POLR3G	physical	17643375
PCBP2_HUMAN	PCBP2	physical	17643375
GRP78_HUMAN	HSPA5	physical	17643375
BORG4_HUMAN	CDC42EP4	physical	17643375
1433E_HUMAN	YWHAE	physical	17643375
RPC9_HUMAN	CRCP	physical	22939629

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.