| UniProt ID | CRNN_HUMAN | |
|---|---|---|
| UniProt AC | Q9UBG3 | |
| Protein Name | Cornulin | |
| Gene Name | CRNN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 495 | |
| Subcellular Localization | Cytoplasm . Does not colocalize with TGM1. | |
| Protein Description | Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.. | |
| Protein Sequence | MPQLLQNINGIIEAFRRYARTEGNCTALTRGELKRLLEQEFADVIVKPHDPATVDEVLRLLDEDHTGTVEFKEFLVLVFKVAQACFKTLSESAEGACGSQESGSLHSGASQELGEGQRSGTEVGRAGKGQHYEGSSHRQSQQGSRGQNRPGVQTQGQATGSAWVSSYDRQAESQSQERISPQIQLSGQTEQTQKAGEGKRNQTTEMRPERQPQTREQDRAHQTGETVTGSGTQTQAGATQTVEQDSSHQTGRTSKQTQEATNDQNRGTETHGQGRSQTSQAVTGGHAQIQAGTHTQTPTQTVEQDSSHQTGSTSTQTQESTNGQNRGTEIHGQGRSQTSQAVTGGHTQIQAGSHTETVEQDRSQTVSHGGAREQGQTQTQPGSGQRWMQVSNPEAGETVPGGQAQTGASTESGRQEWSSTHPRRCVTEGQGDRQPTVVGEEWVDDHSRETVILRLDQGNLHTSVSSAQGQDAAQSEEKRGITARELYSYLRSTKP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Phosphorylation | ARTEGNCTALTRGEL HHCCCCCEECCHHHH | 28.80 | - | |
| 132 | Phosphorylation | RAGKGQHYEGSSHRQ CCCCCCCCCCCCCCC | 17.69 | - | |
| 180 | Phosphorylation | SQSQERISPQIQLSG HHCCCCCCCCEECCC | 19.57 | 29759185 | |
| 203 | Phosphorylation | GEGKRNQTTEMRPER CCCCCCCCCCCCCCC | 28.42 | 27174698 | |
| 204 | Phosphorylation | EGKRNQTTEMRPERQ CCCCCCCCCCCCCCC | 20.30 | 27174698 | |
| 336 | Phosphorylation | EIHGQGRSQTSQAVT EEECCCCCCCCCCCC | 44.63 | 23532336 | |
| 357 | Phosphorylation | QAGSHTETVEQDRSQ ECCCCCCEEECCHHH | 30.42 | 22468782 | |
| 363 | Phosphorylation | ETVEQDRSQTVSHGG CEEECCHHHCCCCCC | 38.19 | 22468782 | |
| 365 | Phosphorylation | VEQDRSQTVSHGGAR EECCHHHCCCCCCCH | 25.81 | 22468782 | |
| 398 | Phosphorylation | SNPEAGETVPGGQAQ CCCCCCCCCCCCCCC | 30.96 | 22817900 | |
| 406 | Phosphorylation | VPGGQAQTGASTESG CCCCCCCCCCCCCCC | 37.42 | 22817900 | |
| 462 | Phosphorylation | LDQGNLHTSVSSAQG EECCCCCCCCHHHCC | 33.71 | 29978859 | |
| 463 | Phosphorylation | DQGNLHTSVSSAQGQ ECCCCCCCCHHHCCC | 14.84 | 29978859 | |
| 465 | Phosphorylation | GNLHTSVSSAQGQDA CCCCCCCHHHCCCCH | 21.52 | 29978859 | |
| 466 | Phosphorylation | NLHTSVSSAQGQDAA CCCCCCHHHCCCCHH | 23.58 | 29978859 | |
| 475 | Phosphorylation | QGQDAAQSEEKRGIT CCCCHHHCHHHHCCC | 42.89 | 29978859 | |
| 482 | Phosphorylation | SEEKRGITARELYSY CHHHHCCCHHHHHHH | 23.61 | - | |
| 487 | Phosphorylation | GITARELYSYLRSTK CCCHHHHHHHHHCCC | 7.19 | - | |
| 489 | Phosphorylation | TARELYSYLRSTKP- CHHHHHHHHHCCCC- | 7.80 | - | |
| 492 | Phosphorylation | ELYSYLRSTKP---- HHHHHHHCCCC---- | 37.88 | - | |
| 493 | Phosphorylation | LYSYLRSTKP----- HHHHHHCCCC----- | 40.68 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CRNN_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CRNN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CRNN_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ADIP_HUMAN | SSX2IP | physical | 28514442 | |
| SLMAP_HUMAN | SLMAP | physical | 28514442 | |
| TRAP1_HUMAN | TRAP1 | physical | 27173435 | |
| IF2P_HUMAN | EIF5B | physical | 27173435 | |
| G6PI_HUMAN | GPI | physical | 27173435 | |
| PDIA3_HUMAN | PDIA3 | physical | 27173435 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-398 AND THR-406, ANDMASS SPECTROMETRY. | |
