BFSP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BFSP1_HUMAN
• UniProt AC: Q12934
• Protein Name: Filensin
• Gene Name: BFSP1
• Organism: Homo sapiens (Human).
• Sequence Length: 665
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Detected adjacent to the cell membrane.
• Protein Sequence: MYRRSYVFQTRKEQYEHADEASRAAEPERPADEGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGPEDALARQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQAQTTTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDRYHRIIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGGKDLTRALQDITAAKPRQKALPKNVPRRKEIITKDKTNGALEDAPLKGLEDTKLVQVVLKEESESKFESESKEVSPLTQEGAPEDVPDGGQISKGFGKLYRKVKEKVRSPKEPETPTELYTKERHVLVTGDANYVDPRFYVSSITAKGGVAVSVAEDSVLYDGQVEPSPESPKPPLENGQVGLQEKEDGQPIDQQPIDKEIEPDGAELEGPEEKREGEERDEESRRPCAMVTPGAEEPSIPEPPKPAADQDGAEVLGTRSRSLPEKGPPKALAYKTVEVVESIEKISTESIQTYEETAVIVETMIGKTKSDKKKSGEKSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MYRRSYVFQTRK ---CCCCCCEECCHH	19.36	-
10	O-linked_Glycosylation	RRSYVFQTRKEQYEH CCCCEECCHHHHHHC	32.04	30620550
42	Acetylation	WAGATSLAALQGLGE CCHHHHHHHHHCHHH	13.09	-
94	Phosphorylation	ALARQVESNRQRVRD HHHHHHHHHHHHHHH	38.16	29978859
185	Phosphorylation	KNLLEVQTYISILQQ HCHHHHHHHHHHHHH	28.18	22210691
186	Phosphorylation	NLLEVQTYISILQQI CHHHHHHHHHHHHHH	3.90	22210691
188	Phosphorylation	LEVQTYISILQQIIH HHHHHHHHHHHHHHH	13.56	24043423
196	Phosphorylation	ILQQIIHTTPPASIV HHHHHHHHCCCHHHH	30.50	24043423
197	Phosphorylation	LQQIIHTTPPASIVT HHHHHHHCCCHHHHC	17.08	24043423
201	Phosphorylation	IHTTPPASIVTSGMR HHHCCCHHHHCCCCC	24.30	22210691
204	Phosphorylation	TPPASIVTSGMREEK CCCHHHHCCCCCHHH	20.21	24043423
205	Phosphorylation	PPASIVTSGMREEKL CCHHHHCCCCCHHHC	21.50	24043423
341	Phosphorylation	QSHGVSLSTGSGGKD CCCCCEECCCCCCHH	24.18	-
357	Phosphorylation	TRALQDITAAKPRQK HHHHHHHHHCCHHHC	28.93	-
397	Phosphorylation	PLKGLEDTKLVQVVL CCCCCCCCEEEEEEE	19.53	-
408	Phosphorylation	QVVLKEESESKFESE EEEECCHHHHHCCCC	48.54	-
410	Phosphorylation	VLKEESESKFESESK EECCHHHHHCCCCCC	52.50	-
420	Phosphorylation	ESESKEVSPLTQEGA CCCCCCCCCCCCCCC	18.45	-
423	Phosphorylation	SKEVSPLTQEGAPED CCCCCCCCCCCCCCC	28.14	-
434	Myristoylation	APEDVPDGGQISKGF CCCCCCCCCCCCCHH	24.68	30790544
460	Phosphorylation	RSPKEPETPTELYTK CCCCCCCCCCCCEEC	46.34	24719451
465	Phosphorylation	PETPTELYTKERHVL CCCCCCCEECCCEEE	14.99	24719451
466	Phosphorylation	ETPTELYTKERHVLV CCCCCCEECCCEEEE	38.77	24719451
479	Phosphorylation	LVTGDANYVDPRFYV EEECCCCCCCCCEEE	14.14	27642862
513	Phosphorylation	YDGQVEPSPESPKPP ECCEECCCCCCCCCC	28.00	-
633	Phosphorylation	ESIEKISTESIQTYE HHHHHHCCCCCCCHH	36.91	-
638	Phosphorylation	ISTESIQTYEETAVI HCCCCCCCHHHHHEE	31.09	-
639	Phosphorylation	STESIQTYEETAVIV CCCCCCCHHHHHEEE	8.73	-
653	Phosphorylation	VETMIGKTKSDKKKS EEHHHCCCCCCCCCC	30.48	-
659	Acetylation	KTKSDKKKSGEKSS- CCCCCCCCCCCCCC-	70.23	7693121
660	Phosphorylation	TKSDKKKSGEKSS-- CCCCCCCCCCCCC--	62.15	-
665	Phosphorylation	KKSGEKSS------- CCCCCCCC-------	56.14	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BFSP1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
41	L	Acetylation	[Filensin N-terminal fragment]: Acetylated at Ala-42 following proteolytic cleavage at Leu-41.	-
42	A	Acetylation	[Filensin N-terminal fragment]: Acetylated at Ala-42 following proteolytic cleavage at Leu-41.	-
433	D	Myristoylation	[Filensin C-terminal fragment]: Myristoylated at Gly-434 following proteolytic cleavage at Asp-433.	30790544
434	G	Myristoylation	[Filensin C-terminal fragment]: Myristoylated at Gly-434 following proteolytic cleavage at Asp-433.	30790544

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BFSP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUP62_HUMAN	NUP62	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.