NUP58_HUMAN - dbPTM
NUP58_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NUP58_HUMAN
UniProt AC Q9BVL2
Protein Name Nucleoporin p58/p45 {ECO:0000305}
Gene Name NUP58 {ECO:0000312|HGNC:HGNC:20261}
Organism Homo sapiens (Human).
Sequence Length 599
Subcellular Localization Nucleus, nuclear pore complex . Nucleus membrane
Peripheral membrane protein
Cytoplasmic side . Nucleus membrane
Peripheral membrane protein
Nucleoplasmic side . Biased towards cytoplasmic side. Central region of the nuclear pore complex, wit
Protein Description Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane..
Protein Sequence MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFGNLGSTSTPATTSAPSSGFGTGLFGSKPATGFTLGGTNTGIATTITTGLTLGTPATTSAATTGFSLGFNKPAASATPFALPITSTSASGLTLSSALTSTPAASTGFTLNNLGGTTATTTTASTGLSLGGALAGLGGSLFQSTNTGTSGLGQNALGLTLGTTAATSTAGNEGLGGIDFSSSSDKKSDKTGTRPEDSKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAANGIQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGTPFGSGIGTGLQSSGLGSSNLGGFGTSSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGITASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Ubiquitination----MSTGFSFGSGT
----CCCCCCCCCCC		22505724
6O-linked_Glycosylation--MSTGFSFGSGTLG
--CCCCCCCCCCCCC		23301498
11O-linked_GlycosylationGFSFGSGTLGSTTVA
CCCCCCCCCCCEEEE		23301498
14O-linked_GlycosylationFGSGTLGSTTVAAGG
CCCCCCCCEEEECCC		23301498
14UbiquitinationFGSGTLGSTTVAAGG
CCCCCCCCEEEECCC		22817900
15O-linked_GlycosylationGSGTLGSTTVAAGGT
CCCCCCCEEEECCCC		23301498
17UbiquitinationGTLGSTTVAAGGTST
CCCCCEEEECCCCCC		21890473
22O-linked_GlycosylationTTVAAGGTSTGGVFS
EEEECCCCCCCCEEE		23301498
23O-linked_GlycosylationTVAAGGTSTGGVFSF
EEECCCCCCCCEEEC		23301498
49O-linked_GlycosylationLNFGNLGSTSTPATT
ECCCCCCCCCCCCCC		23301498
51O-linked_GlycosylationFGNLGSTSTPATTSA
CCCCCCCCCCCCCCC		23301498
52O-linked_GlycosylationGNLGSTSTPATTSAP
CCCCCCCCCCCCCCC		23301498
56O-linked_GlycosylationSTSTPATTSAPSSGF
CCCCCCCCCCCCCCC		23301498
56UbiquitinationSTSTPATTSAPSSGF
CCCCCCCCCCCCCCC		21890473
57O-linked_GlycosylationTSTPATTSAPSSGFG
CCCCCCCCCCCCCCC		23301498
60O-linked_GlycosylationPATTSAPSSGFGTGL
CCCCCCCCCCCCCCC		23301498
74 (in isoform 3)Phosphorylation-22210691
77 (in isoform 3)Phosphorylation-22210691
88O-linked_GlycosylationTNTGIATTITTGLTL
CCCCCEEEEECCCCC		23301498
89 (in isoform 3)Phosphorylation-22210691
90O-linked_GlycosylationTGIATTITTGLTLGT
CCCEEEEECCCCCCC		23301498
94O-linked_GlycosylationTTITTGLTLGTPATT
EEEECCCCCCCCCCC		23301498
97O-linked_GlycosylationTTGLTLGTPATTSAA
ECCCCCCCCCCCCCC		23301498
97PhosphorylationTTGLTLGTPATTSAA
ECCCCCCCCCCCCCC		26853621
97 (in isoform 3)Phosphorylation-22210691
100O-linked_GlycosylationLTLGTPATTSAATTG
CCCCCCCCCCCCCCC		23301498
101O-linked_GlycosylationTLGTPATTSAATTGF
CCCCCCCCCCCCCCC		23301498
102O-linked_GlycosylationLGTPATTSAATTGFS
CCCCCCCCCCCCCCC		23301498
105O-linked_GlycosylationPATTSAATTGFSLGF
CCCCCCCCCCCCCCC		23301498
106O-linked_GlycosylationATTSAATTGFSLGFN
CCCCCCCCCCCCCCC		23301498
109O-linked_GlycosylationSAATTGFSLGFNKPA
CCCCCCCCCCCCCCC		23301498
120O-linked_GlycosylationNKPAASATPFALPIT
CCCCCCCCCCEEEEC		23301498
127O-linked_GlycosylationTPFALPITSTSASGL
CCCEEEECCCCCCCC		23301498
128O-linked_GlycosylationPFALPITSTSASGLT
CCEEEECCCCCCCCC		23301498
129O-linked_GlycosylationFALPITSTSASGLTL
CEEEECCCCCCCCCH		23301498
130O-linked_GlycosylationALPITSTSASGLTLS
EEEECCCCCCCCCHH		23301498
132O-linked_GlycosylationPITSTSASGLTLSSA
EECCCCCCCCCHHHH		23301498
141O-linked_GlycosylationLTLSSALTSTPAAST
CCHHHHHHCCCCCCC		23301498
142O-linked_GlycosylationTLSSALTSTPAASTG
CHHHHHHCCCCCCCC		23301498
143O-linked_GlycosylationLSSALTSTPAASTGF
HHHHHHCCCCCCCCE		23301498
147O-linked_GlycosylationLTSTPAASTGFTLNN
HHCCCCCCCCEEEEC		23301498
148O-linked_GlycosylationTSTPAASTGFTLNNL
HCCCCCCCCEEEECC		23301498
148UbiquitinationTSTPAASTGFTLNNL
HCCCCCCCCEEEECC		23000965
167UbiquitinationATTTTASTGLSLGGA
CEECCCCCCCCHHHH		27667366
201O-linked_GlycosylationGQNALGLTLGTTAAT
CCCCCCCEEECCHHC		23301498
205O-linked_GlycosylationLGLTLGTTAATSTAG
CCCEEECCHHCCCCC		23301498
208O-linked_GlycosylationTLGTTAATSTAGNEG
EEECCHHCCCCCCCC		23301498
209O-linked_GlycosylationLGTTAATSTAGNEGL
EECCHHCCCCCCCCC		23301498
210O-linked_GlycosylationGTTAATSTAGNEGLG
ECCHHCCCCCCCCCC		23301498
219UbiquitinationGNEGLGGIDFSSSSD
CCCCCCCCCCCCCCC		27667366
228UbiquitinationFSSSSDKKSDKTGTR
CCCCCCCCCCCCCCC		27667366
229PhosphorylationSSSSDKKSDKTGTRP
CCCCCCCCCCCCCCH		30576142
231UbiquitinationSSDKKSDKTGTRPED
CCCCCCCCCCCCHHH		27667366
232PhosphorylationSDKKSDKTGTRPEDS
CCCCCCCCCCCHHHH		24719451
234PhosphorylationKKSDKTGTRPEDSKA
CCCCCCCCCHHHHHH		30576142
239PhosphorylationTGTRPEDSKALKDEN
CCCCHHHHHHHCCCC		24719451
240UbiquitinationGTRPEDSKALKDENL
CCCHHHHHHHCCCCC		27667366
248UbiquitinationALKDENLPPVICQDV
HHCCCCCCCCCHHHH		29967540
251UbiquitinationDENLPPVICQDVENL
CCCCCCCCHHHHHHH		27667366
260UbiquitinationQDVENLQKFVKEQKQ
HHHHHHHHHHHHHHH		29967540
263UbiquitinationENLQKFVKEQKQVQE
HHHHHHHHHHHHHHH		27667366
266UbiquitinationQKFVKEQKQVQEEIS
HHHHHHHHHHHHHHH		32015554
273PhosphorylationKQVQEEISRMSSKAM
HHHHHHHHHHHHHHH		23403867
276UbiquitinationQEEISRMSSKAMLKV
HHHHHHHHHHHHHHH		22817900
278UbiquitinationEISRMSSKAMLKVQE
HHHHHHHHHHHHHHH		32015554
279UbiquitinationISRMSSKAMLKVQED
HHHHHHHHHHHHHHH		21890473
279UbiquitinationISRMSSKAMLKVQED
HHHHHHHHHHHHHHH		21890473
279UbiquitinationISRMSSKAMLKVQED
HHHHHHHHHHHHHHH		21890473
288AcetylationLKVQEDIKALKQLLS
HHHHHHHHHHHHHHH		25953088
288UbiquitinationLKVQEDIKALKQLLS
HHHHHHHHHHHHHHH		22817900
291AcetylationQEDIKALKQLLSLAA
HHHHHHHHHHHHHHH		25953088
291UbiquitinationQEDIKALKQLLSLAA
HHHHHHHHHHHHHHH		21890473
291 (in isoform 1)Ubiquitination-21890473
291 (in isoform 2)Ubiquitination-21890473
295PhosphorylationKALKQLLSLAANGIQ
HHHHHHHHHHHCCCC		30177828
298UbiquitinationKQLLSLAANGIQRNT
HHHHHHHHCCCCCCC		29967540
308UbiquitinationIQRNTLNIDKLKIET
CCCCCCCHHHHHHHC		32015554
310UbiquitinationRNTLNIDKLKIETAQ
CCCCCHHHHHHHCHH		29967540
3122-HydroxyisobutyrylationTLNIDKLKIETAQEL
CCCHHHHHHHCHHHH		-
312UbiquitinationTLNIDKLKIETAQEL
CCCHHHHHHHCHHHH		-
318UbiquitinationLKIETAQELKNAEIA
HHHHCHHHHHHCHHH		21890473
318UbiquitinationLKIETAQELKNAEIA
HHHHCHHHHHHCHHH		21890473
318UbiquitinationLKIETAQELKNAEIA
HHHHCHHHHHHCHHH		21890473
319PhosphorylationKIETAQELKNAEIAL
HHHCHHHHHHCHHHH		32142685
320UbiquitinationIETAQELKNAEIALR
HHCHHHHHHCHHHHH		32015554
328PhosphorylationNAEIALRTQKTPPGL
HCHHHHHCCCCCCCC		22115753
330MalonylationEIALRTQKTPPGLQH
HHHHHCCCCCCCCCC		26320211
330UbiquitinationEIALRTQKTPPGLQH
HHHHHCCCCCCCCCC		21890473
330 (in isoform 1)Ubiquitination-21890473
330 (in isoform 2)Ubiquitination-21890473
331PhosphorylationIALRTQKTPPGLQHE
HHHHCCCCCCCCCCC		30266825
339PhosphorylationPPGLQHEYAAPADYF
CCCCCCCCCCCHHHH		28796482
345PhosphorylationEYAAPADYFRILVQQ
CCCCCHHHHHHHHHH		28796482
410UbiquitinationLQSIHENVKVLKEQY
HHHHHHHHHHHHHHH		23000965
4142-HydroxyisobutyrylationHENVKVLKEQYLGYR
HHHHHHHHHHHHCCH		-
414AcetylationHENVKVLKEQYLGYR
HHHHHHHHHHHHCCH		27452117
422UbiquitinationEQYLGYRKMFLGDAV
HHHHCCHHHHHHHHH		23000965
422 (in isoform 1)Ubiquitination-21890473
422 (in isoform 2)Ubiquitination-21890473
423SulfoxidationQYLGYRKMFLGDAVD
HHHCCHHHHHHHHHH		21406390
429UbiquitinationKMFLGDAVDVFETRR
HHHHHHHHHHHHHHH		27667366
441UbiquitinationTRRAEAKKWQNTPRV
HHHHHHHHHCCCCCC		27667366
445O-linked_GlycosylationEAKKWQNTPRVTTGP
HHHHHCCCCCCCCCC		23301498
445PhosphorylationEAKKWQNTPRVTTGP
HHHHHCCCCCCCCCC		28985074
449O-linked_GlycosylationWQNTPRVTTGPTPFS
HCCCCCCCCCCCCCC		23301498
450O-linked_GlycosylationQNTPRVTTGPTPFST
CCCCCCCCCCCCCCC		23301498
453O-linked_GlycosylationPRVTTGPTPFSTMPN
CCCCCCCCCCCCCCH		23301498
471O-linked_GlycosylationVAMAATLTQQQQPAT
HHHHHHHHHCCCCCC		23301498
478O-linked_GlycosylationTQQQQPATGPQPSLG
HHCCCCCCCCCCCCE		23301498
483O-linked_GlycosylationPATGPQPSLGVSFGT
CCCCCCCCCEEECCC		23301498
487O-linked_GlycosylationPQPSLGVSFGTPFGS
CCCCCEEECCCCCCC		23301498
490O-linked_GlycosylationSLGVSFGTPFGSGIG
CCEEECCCCCCCCCC		23301498
522O-linked_GlycosylationTSSGFGCSTTGASTF
CCCCCCCCCCCCCCC		23301498
523O-linked_GlycosylationSSGFGCSTTGASTFG
CCCCCCCCCCCCCCC		23301498
538PhosphorylationFGTTNKPSGSLSAGF
CCCCCCCCCCEEECC		26074081
540PhosphorylationTTNKPSGSLSAGFGS
CCCCCCCCEEECCCC		26074081
542PhosphorylationNKPSGSLSAGFGSSS
CCCCCCEEECCCCCC		26074081
547PhosphorylationSLSAGFGSSSTSGFN
CEEECCCCCCCCCCC		26074081
548PhosphorylationLSAGFGSSSTSGFNF
EEECCCCCCCCCCCC		26074081
549PhosphorylationSAGFGSSSTSGFNFS
EECCCCCCCCCCCCC		26074081
550PhosphorylationAGFGSSSTSGFNFSN
ECCCCCCCCCCCCCC		26074081
551PhosphorylationGFGSSSTSGFNFSNP
CCCCCCCCCCCCCCC		26074081
561O-linked_GlycosylationNFSNPGITASAGLTF
CCCCCCEEEEECEEE		23301498
563O-linked_GlycosylationSNPGITASAGLTFGV
CCCCEEEEECEEECC		23301498
567O-linked_GlycosylationITASAGLTFGVSNPA
EEEEECEEECCCCCC		23301498
571O-linked_GlycosylationAGLTFGVSNPASAGF
ECEEECCCCCCCCCC		23301498
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NUP58_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NUP58_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NUP58_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TOM40_HUMANTOMM40physical
22939629
NUP62_HUMANNUP62physical
25416956
UBQL1_HUMANUBQLN1physical
25416956
ABI3_HUMANABI3physical
25416956
NUP54_HUMANNUP54physical
25416956
DMD_HUMANDMDphysical
26496610
NUP98_HUMANNUP98physical
26496610
RBP2_HUMANRANBP2physical
26496610
NU214_HUMANNUP214physical
26496610
GDF15_HUMANGDF15physical
26496610
NUP93_HUMANNUP93physical
26496610
MRP5_HUMANABCC5physical
26496610
NUPL2_HUMANNUPL2physical
26496610
COG2_HUMANCOG2physical
26496610
NU205_HUMANNUP205physical
26496610
NU188_HUMANNUP188physical
26496610
NUP62_HUMANNUP62physical
26496610
PF21A_HUMANPHF21Aphysical
26496610
NUP54_HUMANNUP54physical
26496610
NDC1_HUMANNDC1physical
26496610
NU107_HUMANNUP107physical
26496610
P33MX_HUMANKIAA1191physical
26496610
NTPCR_HUMANNTPCRphysical
26496610
TOP1M_HUMANTOP1MTphysical
26496610
NUP53_HUMANNUP35physical
26496610
N62CL_HUMANNUP62CLphysical
28514442
MIB2_HUMANMIB2physical
28514442
EEA1_HUMANEEA1physical
28514442
FBX28_HUMANFBXO28physical
28514442
NUP62_HUMANNUP62physical
28514442
OSBL6_HUMANOSBPL6physical
28514442
GOPC_HUMANGOPCphysical
28514442
BRE1B_HUMANRNF40physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NUP58_HUMAN

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