MRP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MRP5_HUMAN
• UniProt AC: O15440
• Protein Name: Multidrug resistance-associated protein 5
• Gene Name: ABCC5
• Organism: Homo sapiens (Human).
• Sequence Length: 1437
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Acts as a multispecific organic anion pump which can transport nucleotide analogs..
• Protein Sequence: MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MKDIDIGKEYIIPSP CCCCCCCCCEECCCC	47.91	29967540
10	Phosphorylation	DIDIGKEYIIPSPGY CCCCCCCEECCCCCC	13.98	27259358
14	Phosphorylation	GKEYIIPSPGYRSVR CCCEECCCCCCCCHH	22.13	28355574
17	Phosphorylation	YIIPSPGYRSVRERT EECCCCCCCCHHHHC	11.78	25159151
19	Phosphorylation	IPSPGYRSVRERTST CCCCCCCCHHHHCCC	19.62	25159151
21	Ubiquitination	SPGYRSVRERTSTSG CCCCCCHHHHCCCCC	29.00	29967540
36	Phosphorylation	THRDREDSKFRRTRP CCCCHHCCCCCCCCC	29.01	29759185
41	Phosphorylation	EDSKFRRTRPLECQD HCCCCCCCCCCHHHH	32.17	32645325
60	Phosphorylation	AARAEGLSLDASMHS HHHHCCCCCCHHHHH	34.75	29255136
64	Phosphorylation	EGLSLDASMHSQLRI CCCCCCHHHHHHHHH	19.39	29255136
67	Phosphorylation	SLDASMHSQLRILDE CCCHHHHHHHHHCCC	23.44	26055452
74	Ubiquitination	SQLRILDEEHPKGKY HHHHHCCCCCCCCCC	55.55	29967540
78	Ubiquitination	ILDEEHPKGKYHHGL HCCCCCCCCCCCCCH	70.69	29967540
82	Ubiquitination	EHPKGKYHHGLSALK CCCCCCCCCCHHCCC	16.42	23503661
83	Ubiquitination	HPKGKYHHGLSALKP CCCCCCCCCHHCCCC	35.48	23503661
86	Ubiquitination	GKYHHGLSALKPIRT CCCCCCHHCCCCCCC	35.83	23503661
88	Ubiquitination	YHHGLSALKPIRTTS CCCCHHCCCCCCCCC	6.44	23503661
89	Ubiquitination	HHGLSALKPIRTTSK CCCHHCCCCCCCCCC	37.81	29967540
91	Ubiquitination	GLSALKPIRTTSKHQ CHHCCCCCCCCCCCC	6.13	23503661
93	Ubiquitination	SALKPIRTTSKHQHP HCCCCCCCCCCCCCC	35.82	29967540
205	Ubiquitination	AFMVKHLLEYTQATE HHHHHHHHHHHHHCC	4.77	21890473
239	Phosphorylation	RSWSLALTWALNYRT HHHHHHHHHHHHCCC	11.77	30631047
260	Ubiquitination	AILTMAFKKILKLKN HHHHHHHHHHHHCCC	29.39	23503661
261	Ubiquitination	ILTMAFKKILKLKNI HHHHHHHHHHHCCCC	46.98	23503661
264	Ubiquitination	MAFKKILKLKNIKEK HHHHHHHHCCCCCCC	61.97	23503661
266	Ubiquitination	FKKILKLKNIKEKSL HHHHHHCCCCCCCCH	55.85	23503661
269	Ubiquitination	ILKLKNIKEKSLGEL HHHCCCCCCCCHHHH	69.36	23503661
325	Ubiquitination	TGFLGSAVFILFYPA CCHHHHHHHHHHHHH	3.08	23503661
326	Ubiquitination	GFLGSAVFILFYPAM CHHHHHHHHHHHHHH	3.93	23503661
346	Ubiquitination	LTAYFRRKCVAATDE HHHHHHHHHHHCCHH	28.89	22817900
347	Ubiquitination	TAYFRRKCVAATDER HHHHHHHHHHCCHHH	2.09	22817900
349	Ubiquitination	YFRRKCVAATDERVQ HHHHHHHHCCHHHHH	17.70	29901268
351	Phosphorylation	RRKCVAATDERVQKM HHHHHHCCHHHHHHH	28.76	46156775
352	Ubiquitination	RKCVAATDERVQKMN HHHHHCCHHHHHHHH	36.66	22817900
383	Ubiquitination	AFSQSVQKIREEERR HHHHHHHHHHHHHHH	41.39	23000965
383	Ubiquitination	AFSQSVQKIREEERR HHHHHHHHHHHHHHH	41.39	21890473
485	Phosphorylation	MIKNKPASPHIKIEM HHHCCCCCCCEEEEE	26.07	25159151
493	Ubiquitination	PHIKIEMKNATLAWD CCEEEEEECCEEEEC	30.55	29967540
494	N-linked_Glycosylation	HIKIEMKNATLAWDS CEEEEEECCEEEECC	36.53	UniProtKB CARBOHYD
496	Phosphorylation	KIEMKNATLAWDSSH EEEEECCEEEECCCC	26.80	23663014
501	Phosphorylation	NATLAWDSSHSSIQN CCEEEECCCCHHHCC	21.17	23401153
502	Phosphorylation	ATLAWDSSHSSIQNS CEEEECCCCHHHCCC	25.56	22167270
504	Phosphorylation	LAWDSSHSSIQNSPK EEECCCCHHHCCCCC	30.96	22167270
505	Phosphorylation	AWDSSHSSIQNSPKL EECCCCHHHCCCCCC	23.83	22167270
505	Ubiquitination	AWDSSHSSIQNSPKL EECCCCHHHCCCCCC	23.83	22817900
509	Phosphorylation	SHSSIQNSPKLTPKM CCHHHCCCCCCCHHH	13.67	22167270
513	Phosphorylation	IQNSPKLTPKMKKDK HCCCCCCCHHHHHCC	27.30	25159151
546	Ubiquitination	QAVLAEQKGHLLLDS HHHHHHHHCCEEECC	39.54	29967540
553	Phosphorylation	KGHLLLDSDERPSPE HCCEEECCCCCCCCC	41.14	29255136
558	Phosphorylation	LDSDERPSPEEEEGK ECCCCCCCCCHHCCC	51.68	30266825
565	Ubiquitination	SPEEEEGKHIHLGHL CCCHHCCCCCEEHHH	42.54	29967540
619	Ubiquitination	MTLLEGSIAISGTFA CCHHCCCEEECCHHH	6.08	23503661
620	Ubiquitination	TLLEGSIAISGTFAY CHHCCCEEECCHHHH	7.50	23503661
636	N-linked_Glycosylation	AQQAWILNATLRDNI HHHHHHHCCCHHCCC	23.03	UniProtKB CARBOHYD
640	Ubiquitination	WILNATLRDNILFGK HHHCCCHHCCCCCCC	30.49	22817900
641	Ubiquitination	ILNATLRDNILFGKE HHCCCHHCCCCCCCC	50.03	22817900
643	Ubiquitination	NATLRDNILFGKEYD CCCHHCCCCCCCCCC	3.85	22817900
646	Ubiquitination	LRDNILFGKEYDEER HHCCCCCCCCCCHHH	20.59	22817900
684	N-linked_Glycosylation	EIGERGANLSGGQRQ CHHHCCCCCCHHHHH	37.25	UniProtKB CARBOHYD
686	Phosphorylation	GERGANLSGGQRQRI HHCCCCCCHHHHHHH	40.46	20363803
696	Ubiquitination	QRQRISLARALYSDR HHHHHHHHHHHHCCC	6.47	21963094
707	Ubiquitination	YSDRSIYILDDPLSA HCCCEEEEECCCHHH	3.03	23503661
709	Ubiquitination	DRSIYILDDPLSALD CCEEEEECCCHHHHH	46.02	23503661
726	Phosphorylation	VGNHIFNSAIRKHLK HHHHHHHHHHHHHHC	17.83	24719451
739	Ubiquitination	LKSKTVLFVTHQLQY HCCCEEEEECCCHHH	5.32	29967540
740	Ubiquitination	KSKTVLFVTHQLQYL CCCEEEEECCCHHHH	4.00	23503661
746	Ubiquitination	FVTHQLQYLVDCDEV EECCCHHHHCCCCEE	19.79	33845483
748	Ubiquitination	THQLQYLVDCDEVIF CCCHHHHCCCCEEEE	6.15	23503661
750	Ubiquitination	QLQYLVDCDEVIFMK CHHHHCCCCEEEEEE	3.61	23503661
796	Phosphorylation	TPPVEINSKKETSGS CCCEECCCCCCCCCC	51.25	24260401
797	Ubiquitination	PPVEINSKKETSGSQ CCEECCCCCCCCCCC	50.57	23503661
798	Acetylation	PVEINSKKETSGSQK CEECCCCCCCCCCCC	67.07	20167786
798	Ubiquitination	PVEINSKKETSGSQK CEECCCCCCCCCCCC	67.07	23503661
799	Ubiquitination	VEINSKKETSGSQKK EECCCCCCCCCCCCC	52.52	22817900
800	Phosphorylation	EINSKKETSGSQKKS ECCCCCCCCCCCCCC	47.47	21654683
805	Acetylation	KETSGSQKKSQDKGP CCCCCCCCCCCCCCC	56.97	30586675
806	Acetylation	ETSGSQKKSQDKGPK CCCCCCCCCCCCCCC	45.79	20167786
807	Phosphorylation	TSGSQKKSQDKGPKT CCCCCCCCCCCCCCC	51.12	21654691
814	Phosphorylation	SQDKGPKTGSVKKEK CCCCCCCCCCCCCHH	37.51	21654699
818	Ubiquitination	GPKTGSVKKEKAVKP CCCCCCCCCHHCCCC	57.84	22817900
819	Ubiquitination	PKTGSVKKEKAVKPE CCCCCCCCHHCCCCC	63.39	22817900
821	Ubiquitination	TGSVKKEKAVKPEEG CCCCCCHHCCCCCCC	68.32	21906983
821	Ubiquitination	TGSVKKEKAVKPEEG CCCCCCHHCCCCCCC	68.32	21890473
824	Ubiquitination	VKKEKAVKPEEGQLV CCCHHCCCCCCCCEE	52.12	21906983
824	Ubiquitination	VKKEKAVKPEEGQLV CCCHHCCCCCCCCEE	52.12	21890473
837	Ubiquitination	LVQLEEKGQGSVPWS EEEEECCCCCCCCHH	40.12	29901268
890	N-linked_Glycosylation	WIKQGSGNTTVTRGN HHHCCCCCCEEECCC	33.98	UniProtKB CARBOHYD
897	N-linked_Glycosylation	NTTVTRGNETSVSDS CCEEECCCCCCCCHH	46.19	UniProtKB CARBOHYD
902	Phosphorylation	RGNETSVSDSMKDNP CCCCCCCCHHCCCCC	24.60	21601212
965	Phosphorylation	SPMKFFDTTPTGRIL CCCHHCCCCCCHHHH	29.53	30619164
966	Phosphorylation	PMKFFDTTPTGRILN CCHHCCCCCCHHHHH	22.24	30619164
968	Phosphorylation	KFFDTTPTGRILNRF HHCCCCCCHHHHHHC	36.68	30619164
977	Ubiquitination	RILNRFSKDMDEVDV HHHHHCCCCCCCCCC	55.12	22817900
977	Ubiquitination	RILNRFSKDMDEVDV HHHHHCCCCCCCCCC	55.12	21890473
990	Ubiquitination	DVRLPFQAEMFIQNV CCCCHHCHHHHHHHH	15.59	21963094
1001	Ubiquitination	IQNVILVFFCVGMIA HHHHHHHHHHHHHHH	3.35	23503661
1003	Ubiquitination	NVILVFFCVGMIAGV HHHHHHHHHHHHHHH	1.43	23503661
1034	Ubiquitination	VLHIVSRVLIRELKR HHHHHHHHHHHHHHH	3.98	23503661
1040	Ubiquitination	RVLIRELKRLDNITQ HHHHHHHHHHCCCCC	46.27	23503661
1042	Ubiquitination	LIRELKRLDNITQSP HHHHHHHHCCCCCCC	5.89	23503661
1044	N-linked_Glycosylation	RELKRLDNITQSPFL HHHHHHCCCCCCCHH	43.74	UniProtKB CARBOHYD
1044	Ubiquitination	RELKRLDNITQSPFL HHHHHHCCCCCCCHH	43.74	23503661
1166	Phosphorylation	SVERINHYIKTLSLE CHHHHHHHHHHCCCC	10.30	7949285
1168	Ubiquitination	ERINHYIKTLSLEAP HHHHHHHHHCCCCCC	35.93	21963094
1179	Ubiquitination	LEAPARIKNKAPSPD CCCCCCCCCCCCCCC	47.01	23503661
1181	Ubiquitination	APARIKNKAPSPDWP CCCCCCCCCCCCCCC	57.58	23503661
1202	Phosphorylation	FENAEMRYRENLPLV ECCHHHHHHHCCCEE	22.44	119441
1211	Ubiquitination	ENLPLVLKKVSFTIK HCCCEEEEEEEEEEC	43.58	29967540
1212	Ubiquitination	NLPLVLKKVSFTIKP CCCEEEEEEEEEECC	38.66	23503661
1216	Phosphorylation	VLKKVSFTIKPKEKI EEEEEEEEECCHHHE	22.15	50558633
1218	Ubiquitination	KKVSFTIKPKEKIGI EEEEEEECCHHHEEE	47.16	33845483
1220	Ubiquitination	VSFTIKPKEKIGIVG EEEEECCHHHEEEEE	67.64	23503661
1222	Ubiquitination	FTIKPKEKIGIVGRT EEECCHHHEEEEECC	52.97	23503661
1229	Phosphorylation	KIGIVGRTGSGKSSL HEEEEECCCCCHHHH	29.75	-
1231	Phosphorylation	GIVGRTGSGKSSLGM EEEECCCCCHHHHHH	42.29	-
1268	Phosphorylation	IGLADLRSKLSIIPQ CCHHHHHHCCCCCCC	45.29	46156769
1281	Phosphorylation	PQEPVLFSGTVRSNL CCCCCCCCCCCCCCC	29.41	22468782
1286	Phosphorylation	LFSGTVRSNLDPFNQ CCCCCCCCCCCCCCC	37.09	22468782
1295	Phosphorylation	LDPFNQYTEDQIWDA CCCCCCCCHHHHHHH	24.26	22468782
1309	Ubiquitination	ALERTHMKECIAQLP HHHHHCHHHHHHCCC	41.66	29901268
1329	N-linked_Glycosylation	EVMENGDNFSVGERQ HHHHCCCCCCHHHHH	32.27	UniProtKB CARBOHYD
1417	N-linked_Glycosylation	TPSVLLSNDSSRFYA CCCEEECCCHHHHHH	53.83	UniProtKB CARBOHYD
1423	Phosphorylation	SNDSSRFYAMFAAAE CCCHHHHHHHHHHHC	8.95	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MRP5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MRP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MRP5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMC2_HUMAN	SMC2	physical	21988832
AACT_HUMAN	SERPINA3	physical	21988832
KAD2_HUMAN	AK2	physical	21988832
RET5_HUMAN	RBP5	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00718: Adefovir Dipivoxil
• DB00770: Alprostadil
• DB01076: Atorvastatin
• DB00515: Cisplatin
• DB00917: Dinoprostone
• DB00975: Dipyridamole
• DB00544: Fluorouracil
• DB00143: Glutathione
• DB01033: Mercaptopurine
• DB01032: Probenecid
• DB01045: Rifampicin
• DB00203: Sildenafil
• DB01138: Sulfinpyrazone
• DB00495: Zidovudine

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505; SER-509 ANDTHR-513, AND MASS SPECTROMETRY.
PubMed: 18669648