PRS4_MOUSE - dbPTM
PRS4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRS4_MOUSE
UniProt AC P62192
Protein Name 26S proteasome regulatory subunit 4
Gene Name Psmc1
Organism Mus musculus (Mouse).
Sequence Length 440
Subcellular Localization Cytoplasm. Nucleus. Membrane
Lipid-anchor .
Protein Description Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides..
Protein Sequence MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGQSQSGGH
------CCCCCCCCC		35.5316857966
4Phosphorylation----MGQSQSGGHGP
----CCCCCCCCCCC		22.15-
24UbiquitinationDDKDKKKKYEPPVPT
CCCCHHHCCCCCCCC		64.82-
24MalonylationDDKDKKKKYEPPVPT
CCCCHHHCCCCCCCC		64.8226320211
25PhosphorylationDKDKKKKYEPPVPTR
CCCHHHCCCCCCCCC		42.4122499769
48UbiquitinationKGPDAASKLPLVTPH
CCCCHHHCCCCCCCC		49.7722790023
53PhosphorylationASKLPLVTPHTQCRL
HHCCCCCCCCCHHHH		19.6226824392
56PhosphorylationLPLVTPHTQCRLKLL
CCCCCCCCHHHHHHH		30.4828833060
58S-nitrosocysteineLVTPHTQCRLKLLKL
CCCCCCHHHHHHHHH		6.06-
58S-palmitoylationLVTPHTQCRLKLLKL
CCCCCCHHHHHHHHH		6.0626165157
58S-nitrosylationLVTPHTQCRLKLLKL
CCCCCCHHHHHHHHH		6.0621278135
58GlutathionylationLVTPHTQCRLKLLKL
CCCCCCHHHHHHHHH		6.0624333276
69UbiquitinationLLKLERIKDYLLMEE
HHHHHHHHHHHHHHH		46.6822790023
91UbiquitinationQMKPLEEKQEEERSK
HCCCHHHHHHHHHHC		54.3422790023
97PhosphorylationEKQEEERSKVDDLRG
HHHHHHHHCHHHHCC		40.0721659604
98UbiquitinationKQEEERSKVDDLRGT
HHHHHHHCHHHHCCC		56.7722790023
178UbiquitinationVTVMKVEKAPQETYA
EEEEEEEECCCCHHH		69.2422790023
232UbiquitinationYGPPGTGKTLLAKAV
ECCCCCCHHHHHHHH		35.5222790023
237UbiquitinationTGKTLLAKAVANQTS
CCHHHHHHHHHCCCC		43.2822790023
237AcetylationTGKTLLAKAVANQTS
CCHHHHHHHHHCCCC		43.2822826441
258UbiquitinationVGSELIQKYLGDGPK
HCHHHHHHHHCCCHH		35.1322790023
258AcetylationVGSELIQKYLGDGPK
HCHHHHHHHHCCCHH		35.1323806337
265UbiquitinationKYLGDGPKLVRELFR
HHHCCCHHHHHHHHH		66.2122790023
293UbiquitinationEIDAIGTKRYDSNSG
ECCCCCCCCCCCCCC		43.6922790023
297PhosphorylationIGTKRYDSNSGGERE
CCCCCCCCCCCCHHH		24.7825338131
359UbiquitinationEFPLPDEKTKKRIFQ
ECCCCCHHHHHHEEE		73.3822790023
370PhosphorylationRIFQIHTSRMTLADD
HEEEEECCCCCCCCC		13.0929514104
387UbiquitinationLDDLIMAKDDLSGAD
HHHHHHCCCCCCCCC		34.1022790023
396UbiquitinationDLSGADIKAICTEAG
CCCCCCHHHHHHHHH		32.0422790023
399GlutathionylationGADIKAICTEAGLMA
CCCHHHHHHHHHHHH		3.1724333276
420SuccinylationKVTNEDFKKSKENVL
CCCHHHHHHHHHHCE		69.3423954790
423UbiquitinationNEDFKKSKENVLYKK
HHHHHHHHHHCEEEC		63.2922790023
434PhosphorylationLYKKQEGTPEGLYL-
EEECCCCCCCCCCC-		19.8823984901
439PhosphorylationEGTPEGLYL------
CCCCCCCCC------		22.6325159016
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRS4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRS4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRS4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NGLY1_MOUSENgly1physical
16249333
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRS4_MOUSE

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Related Literatures of Post-Translational Modification

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