dbPTM

K2C5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	K2C5_MOUSE
UniProt AC	Q922U2
Protein Name	Keratin, type II cytoskeletal 5
Gene Name	Krt5 {ECO:0000250\|UniProtKB:P13647}
Organism	Mus musculus (Mouse).
Sequence Length	580
Subcellular Localization
Protein Description
Protein Sequence	MSRQSSVSFRSGGSRSFSAASAITPSVSRTSFSSVSRSGGGGGGRISLGGACGAGGYGSRSLYNVGGSKRISYSSGGGSFRNQFGAGGFGFGGGAGSGFGFGGGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTVNQNLLTPLNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTIKQNLDPLFEQYINNLRRQLDGVLGERGRLDSELRNMQDLVEDYKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEARVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRSEIDNVKKQCANLQNAIAEAEQRGELALKDARNKLTELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTNSVSSGYGGGSSIGVGSGFGGGLGSGFAGGLGPRFTRGGGGLGLGSGLSVGGSGFSAGSSQGGMSFGSGGGSGSSVKFVSTTSSSRRSFKS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRQSSVSF ------CCCCCCCEE	38.74	-
5	Phosphorylation	---MSRQSSVSFRSG ---CCCCCCCEECCC	31.43	-
6	Phosphorylation	--MSRQSSVSFRSGG --CCCCCCCEECCCC	17.28	21183079
8	Phosphorylation	MSRQSSVSFRSGGSR CCCCCCCEECCCCCC	19.52	22817900
11	Phosphorylation	QSSVSFRSGGSRSFS CCCCEECCCCCCCCC	45.56	-
16	Phosphorylation	FRSGGSRSFSAASAI ECCCCCCCCCHHHCC	25.83	22817900
18	Phosphorylation	SGGSRSFSAASAITP CCCCCCCCHHHCCCC	24.95	22817900
21	Phosphorylation	SRSFSAASAITPSVS CCCCCHHHCCCCCCC	21.66	22817900
24	Phosphorylation	FSAASAITPSVSRTS CCHHHCCCCCCCCCC	14.82	-
26	Phosphorylation	AASAITPSVSRTSFS HHHCCCCCCCCCCCC	24.87	22817900
28	Phosphorylation	SAITPSVSRTSFSSV HCCCCCCCCCCCCEE	33.89	22817900
31	Phosphorylation	TPSVSRTSFSSVSRS CCCCCCCCCCEECCC	23.24	22817900
33	Phosphorylation	SVSRTSFSSVSRSGG CCCCCCCCEECCCCC	29.60	19060867
34	Phosphorylation	VSRTSFSSVSRSGGG CCCCCCCEECCCCCC	23.31	22817900
36	Phosphorylation	RTSFSSVSRSGGGGG CCCCCEECCCCCCCC	23.76	22817900
47	Phosphorylation	GGGGGRISLGGACGA CCCCCCEECCCCCCC	21.43	22817900
57	Phosphorylation	GACGAGGYGSRSLYN CCCCCCCCCCCCEEE	15.83	19367708
61	Phosphorylation	AGGYGSRSLYNVGGS CCCCCCCCEEECCCC	36.58	22817900
63	Phosphorylation	GYGSRSLYNVGGSKR CCCCCCEEECCCCCC	14.73	24719451
68	Phosphorylation	SLYNVGGSKRISYSS CEEECCCCCCEEECC	16.90	22817900
72	Phosphorylation	VGGSKRISYSSGGGS CCCCCCEEECCCCCC	24.01	22817900
73	Phosphorylation	GGSKRISYSSGGGSF CCCCCEEECCCCCCC	12.41	26060331
74	Phosphorylation	GSKRISYSSGGGSFR CCCCEEECCCCCCCC	18.73	22817900
75	Phosphorylation	SKRISYSSGGGSFRN CCCEEECCCCCCCCC	32.97	19367708
79	Phosphorylation	SYSSGGGSFRNQFGA EECCCCCCCCCCCCC	25.06	22817900
145	Phosphorylation	TVNQNLLTPLNLQID EECCCCCCCCCCCCC	28.97	-
160	Phosphorylation	PTIQRVRTEEREQIK CCHHHHCHHHHHHHH	39.06	-
168	Phosphorylation	EEREQIKTLNNKFAS HHHHHHHHHHHHHHH	36.03	29899451
172	Ubiquitination	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
175	Phosphorylation	TLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	22817900
179	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	-
188	Ubiquitination	RFLEQQNKVLDTKWA HHHHHHHCHHHHHHH	39.58	-
193	Ubiquitination	QNKVLDTKWALLQEQ HHCHHHHHHHHHHHH	30.09	-
236	Phosphorylation	GERGRLDSELRNMQD CCCCHHHHHHHHHHH	43.02	22802335
251	Acetylation	LVEDYKNKYEDEINK HHHHHHHHHHHHHHH	45.95	55169323
258	Acetylation	KYEDEINKRTTAENE HHHHHHHHCCCCCCE	57.70	-
326	Phosphorylation	LSMDNNRSLDLDSII EECCCCCCCCHHHHH	28.49	22817900
331	Phosphorylation	NRSLDLDSIIAEVKA CCCCCHHHHHHHHHH	24.16	22817900
340	Phosphorylation	IAEVKAQYEDIANRS HHHHHHHHHHHHHCC	22.04	-
347	Phosphorylation	YEDIANRSRTEAESW HHHHHHCCHHHHHHH	43.28	29899451
392	Phosphorylation	RMIQRLRSEIDNVKK HHHHHHHHHHHHHHH	43.42	20139300
466	Ubiquitination	VEIATYRKLLEGEEC HHHHHHHHHHCCCCC	47.19	-
526	Methylation	GLGPRFTRGGGGLGL CCCCCCCCCCCCCCC	38.76	24129315
548	Phosphorylation	GSGFSAGSSQGGMSF CCCCCCCCCCCCCCC	21.14	19367708
569	Phosphorylation	GSSVKFVSTTSSSRR CCCEEEEECCCCCCC	29.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
24	T	Phosphorylation	Kinase	CDK1	P11440	PSP
31	S	Phosphorylation	Kinase	AURKB	O70126	GPS
145	T	Phosphorylation	Kinase	CDK1	P11440	PSP
160	T	Phosphorylation	Kinase	ROCK1	P70335	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of K2C5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of K2C5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of K2C5_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of K2C5_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-61 AND SER-72,AND MASS SPECTROMETRY.	19367708 [Abstract]