MGAP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGAP_MOUSE
• UniProt AC: A2AWL7
• Protein Name: MAX gene-associated protein
• Gene Name: Mga
• Organism: Mus musculus (Mouse).
• Sequence Length: 3003
• Subcellular Localization: Nucleus .
• Protein Description: Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor..
• Protein Sequence: MEEKQQIILANQDGGTVTGGAPTFFVILKQPGNGKTDQGILVTNRDARALLSRESSPGKSKEKICLPADCTVGKITVTLDNNSMWNEFHNRSTEMILTKQGRRMFPYCRYWITGLDSNLKYILVMDISPVDSHRYKWNGRWWEPSGKAEPHILGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPAEKATEVIQLNGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRDDGLSSKPQREGKQRNSSDQEGNSVSSSPAHRVRLTEGEGSEIHSGDFDPVLRGHEASSLSLEKAPHNVKQDFLGFMNTDSTHEVPQLKHEISESRIVNSFEDDSQISSPSNPNGNFNVVIKEEPLDDYDYELGECPEGITVKQEETDEETDVYSNSDDDPILEKQLKRHNKVDNLEADHPSYKWLPNSPGVAKAKMFKLDAGKMPVVYLEPCAVTKSTVKISELPDNMLSTSRKDKSMLAELEYLPAYIENSDGTDFCLSKDSENSLRKHSPDLRIVQKYTLLKEPNWKYPDILDNSSTERIHDSSKGSTAESFSGKEDLGKKRTTMLKMAIPSKTVTASHSASPNTPGKRGRPRKLRLSKAGRPPKNTGKSLTAAKNIPVGPGSTFPDVKPDLEDVDGVLFVSFESKEALDIHAVDGTTEEPSSLQTTTTNDSGCRTRISQLEKELIEDLKSLRHKQVIHPALQEVGLKLNSVDPTVSIDLKYLGVQLPLAPATSFPLWNVTGTNPASPDAGFPFVSRTGKTNDFTKIKGWRGKFQNASASRNEGGNSEASLKNRSAFCSDKLDEYLENEGKLMETNIGFSSNAPTSPVVYQLPTKSTSYVRTLDSVLKKQSTISPSTSHSVKPQSVTTASRKTKAQNKQTTLSGRTKSSYKSILPYPVSPKQKNSHVSQGDKITKNSLSSTSDNQVTNLVVPSVDENAFPKQISLRQAQQQHLQQQGTRPPGLSKSQVKLMDLEDCALWEGKPRTYITEERADVSLTTLLTAQASLKTKPIHTIIRKRAPPCNNDFCRLGCVCSSLALEKRQPAHCRRPDCMFGCTCLKRKVVLVKGGSKTKHFHKKAANRDPLFYDTLGEEGREGGGVREDEEQLKEKKKRKKLEYTVCEAEPEQPVRHYPLWVKVEGEVDPEPVYIPTPSVIEPIKPLVLPQPDLSSTTKGKLTPGIKPARTYTPKPNPVIREEDKDPVYLYFESMMTCARVRVYERKKEEQRQLSPPLSPSSSFQQQSSCYSSPENRVTKELDSEQTLKQLICDLEDDSDKSQEKSWKSSCNEGESSSTSYVHQRSPGGPTKLIEIISDCNWEEDRNKILSILSQHINSNMPQSLKVGSFIIELASQRKCRGEKTPPVYSSRVKISMPSSQDQDDMAEKSGSETPDGPLSPGKMDDISPVQTDALDSVRERLHGGKGLPFYAGLSPSGKLVAYKRKPSSTTSGLIQVASNAKVAASRKPRTLLPSTSNSKMASSGPATNRSGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVRTPQPLTGPQKFSIRPSPVMVVTPVVSSEQVQVCSTVAAAVTTSPQVFLENVTAVPSLTANSDMGAKEATYSSSASTAGVVEISETNNTTLVTSTQSTATVNLTKTTGITTSPVASVSFAKPLVASPTITLPVASTASTSIVMVTTAASSSVVTTPTSSLSSVPIILSGINGSPPVSQRPENAPQIPVTTPQISSNNVKRTGPRLLHPNGQIVQLLPLHQIRGSNAQPSLQPVVFRNPGSMVGIRLPAPCKSSETPSSSASSSAFSVMSPVIQAVGSSPTVNVISQAPSLLSSGSSFVSQAGTLTLRISPPETQNLASKTGSESKITPSTGGQPVGTASLIPLQSGSFALLQLPGQKPIPSSVLQHVASLQIKKESQSTDQKDETNSIKREEETKKALPSKDKALDSEANIMKQNSGIIASENTSNNSLDDGGDLLDEETLREDARPYEYSYSTGSHTDEDKDGDEDSGNKNQNSPKEKQTVPEVRAGSKNIDIMALQSIRSIRPQKCVKVKVEPQEGSDNPENPDDFLVLSKDSKFELSGNQVKEQQSNSQAEAKKDCEDSLGKDSLRERWRKHLKGPLTQKYIGISQNFNKEANVQFFTEMKPCQENSEQDISELLGKSGTIESGGVLKTEDGSWSGISSSAAFSIIPRRATKGRRGSRHFQGHLLLPREQMKPKQQTKDGRSSAADFTVLDLEDEDEEDEKTDDSLDEIVDVVSGYQSEEVDVEKNNYVDYLEDDEQVDVETIEELSEEINFPYKKTTATHTQSFKQQCHSHISADEKASEKSRKVSLISSKLKDDCWGDKPHKETEAFAYYRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLSRKRSILIRKVSSLSGKTEEVVLKKLEYIYAKQQALEAQKRKKKLGSDEFCVSPRIGTQLEGSSASSVDLGQMLMNNRRGKPLILSRKRDQATENASPSDTPHSSANLVMTPQGQLLTLKGPLFSGPVVAVSPALLEGGLKPQVASSTMSQSENDDLFMMPRIVNVTSLAAEEDLGGMSGNKYRHEVPDGKPLDHLRDIAGSEASSLKDTERISSRGNHRDSRKALGPTQVLLANKDSGFPHVADVSTMQAAQEFIPKNMSGDVRGHRYKWKECELRGERLKSKESQFHKLKMKDLKDSSIEMELRKVASAIEEAALHPSELLTNMEDEDDTDETLTSLLNEIAFLNQQLNDDSGLAELSGSMDTEFSGDAQRAFISKLAPGNRSAFQVGHLGAGVKELPDVQEESESISPLLLHLEDDDFSENEKQLGDTASEPDVLKIVIDPEIKDSLVSHRKSSDGGQSTSGLPAEPESVSSPPILHMKTGPENSNTDTLWRPMPKLAPLGLKVANPPSDADGQSLKVMPALAPIAAKVGSIGHKMNLAGIDQEGRGSKVMPTLAPVVPKLGNSGAPSSSSGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	RDARALLSRESSPGK HHHHHHHCCCCCCCC	34.55	29514104
55	Phosphorylation	RALLSRESSPGKSKE HHHHCCCCCCCCCCC	40.50	26745281
56	Phosphorylation	ALLSRESSPGKSKEK HHHCCCCCCCCCCCC	32.68	29514104
276	Phosphorylation	REGKQRNSSDQEGNS CCCCCCCCCCCCCCC	37.16	25777480
277	Phosphorylation	EGKQRNSSDQEGNSV CCCCCCCCCCCCCCC	47.03	29895711
283	Phosphorylation	SSDQEGNSVSSSPAH CCCCCCCCCCCCCCE	33.94	29895711
285	Phosphorylation	DQEGNSVSSSPAHRV CCCCCCCCCCCCEEE	25.56	21149613
286	Phosphorylation	QEGNSVSSSPAHRVR CCCCCCCCCCCEEEE	37.88	21149613
287	Phosphorylation	EGNSVSSSPAHRVRL CCCCCCCCCCEEEEC	20.71	25521595
368	Phosphorylation	EDDSQISSPSNPNGN CCCCCCCCCCCCCCC	33.70	30352176
406	Phosphorylation	ITVKQEETDEETDVY EEEECCCCCCCCCCC	48.21	21149613
410	Phosphorylation	QEETDEETDVYSNSD CCCCCCCCCCCCCCC	28.81	21149613
448	Phosphorylation	SYKWLPNSPGVAKAK CCCCCCCCCCCCEEE	22.53	22942356
482	Phosphorylation	TKSTVKISELPDNML ECCEEEHHHCCCCCC	27.62	28059163
531	Phosphorylation	ENSLRKHSPDLRIVQ CCHHHHHCCCHHHHH	24.12	-
596	Phosphorylation	KMAIPSKTVTASHSA HHCCCCCEEEECCCC	27.68	29472430
598	Phosphorylation	AIPSKTVTASHSASP CCCCCEEEECCCCCC	27.89	29472430
600	Phosphorylation	PSKTVTASHSASPNT CCCEEEECCCCCCCC	14.49	29472430
602	Phosphorylation	KTVTASHSASPNTPG CEEEECCCCCCCCCC	28.13	29895711
604	Phosphorylation	VTASHSASPNTPGKR EEECCCCCCCCCCCC	23.00	25266776
607	Phosphorylation	SHSASPNTPGKRGRP CCCCCCCCCCCCCCC	36.48	25266776
705	Ubiquitination	TRISQLEKELIEDLK HHHHHHHHHHHHHHH	67.43	-
733	Phosphorylation	EVGLKLNSVDPTVSI HHCCCCCCCCCCCEE	38.03	26239621
737	Phosphorylation	KLNSVDPTVSIDLKY CCCCCCCCCEEEEEE	23.56	26239621
744	Phosphorylation	TVSIDLKYLGVQLPL CCEEEEEECCCCCCC	18.91	-
755	Phosphorylation	QLPLAPATSFPLWNV CCCCCCCCCCCCEEC	29.82	-
763	Phosphorylation	SFPLWNVTGTNPASP CCCCEECCCCCCCCC	34.77	26643407
765	Phosphorylation	PLWNVTGTNPASPDA CCEECCCCCCCCCCC	28.76	26643407
769	Phosphorylation	VTGTNPASPDAGFPF CCCCCCCCCCCCCCC	25.27	26745281
778	Phosphorylation	DAGFPFVSRTGKTND CCCCCCCCCCCCCCC	25.22	26643407
780	Phosphorylation	GFPFVSRTGKTNDFT CCCCCCCCCCCCCCC	35.21	26643407
795	Acetylation	KIKGWRGKFQNASAS CCCCCCCCCCCCCCC	34.89	23806337
837	Phosphorylation	NEGKLMETNIGFSSN HCCCEEEEEECCCCC	20.40	22802335
842	Phosphorylation	METNIGFSSNAPTSP EEEEECCCCCCCCCC	19.92	29109428
843	Phosphorylation	ETNIGFSSNAPTSPV EEEECCCCCCCCCCE	34.45	29472430
847	Phosphorylation	GFSSNAPTSPVVYQL CCCCCCCCCCEEEEC	43.16	26745281
848	Phosphorylation	FSSNAPTSPVVYQLP CCCCCCCCCEEEECC	18.03	25266776
852	Phosphorylation	APTSPVVYQLPTKST CCCCCEEEECCCCCC	12.45	29472430
856	Phosphorylation	PVVYQLPTKSTSYVR CEEEECCCCCCHHHH	46.34	29472430
876	Phosphorylation	LKKQSTISPSTSHSV HHHCCCCCCCCCCCC	16.94	-
882	Phosphorylation	ISPSTSHSVKPQSVT CCCCCCCCCCCCCCC	31.44	-
887	Phosphorylation	SHSVKPQSVTTASRK CCCCCCCCCCCCCHH	29.93	28418008
890	Phosphorylation	VKPQSVTTASRKTKA CCCCCCCCCCHHHCC	22.08	28418008
918	Phosphorylation	SYKSILPYPVSPKQK CCCCCCCCCCCHHHC	16.90	28833060
921	Phosphorylation	SILPYPVSPKQKNSH CCCCCCCCHHHCCCC	23.13	25521595
966	Phosphorylation	NAFPKQISLRQAQQQ CCCCHHCCHHHHHHH	18.27	22942356
1027	Phosphorylation	TLLTAQASLKTKPIH HHHHHHHHCCCCCCC	20.51	21183079
1224	Phosphorylation	EEDKDPVYLYFESMM CCCCCCEEEEEEHHH	10.89	-
1250	Phosphorylation	KEEQRQLSPPLSPSS HHHHHCCCCCCCCCH	19.01	26643407
1254	Phosphorylation	RQLSPPLSPSSSFQQ HCCCCCCCCCHHHHH	28.63	26643407
1256	Phosphorylation	LSPPLSPSSSFQQQS CCCCCCCCHHHHHHH	34.93	26643407
1257	Phosphorylation	SPPLSPSSSFQQQSS CCCCCCCHHHHHHHH	38.26	26643407
1258	Phosphorylation	PPLSPSSSFQQQSSC CCCCCCHHHHHHHHC	31.26	24759943
1294	Phosphorylation	ICDLEDDSDKSQEKS HHCCCCCCCHHHHHH	60.30	29514104
1297	Phosphorylation	LEDDSDKSQEKSWKS CCCCCCHHHHHHHHH	48.87	29514104
1346	Phosphorylation	EDRNKILSILSQHIN HHHHHHHHHHHHHHH	25.59	21183079
1354	Phosphorylation	ILSQHINSNMPQSLK HHHHHHHCCCCCCCC	33.62	21183079
1380	Phosphorylation	RKCRGEKTPPVYSSR CCCCCCCCCCCCCCC	28.64	-
1405	Phosphorylation	QDDMAEKSGSETPDG HHHHHHHCCCCCCCC	38.77	29550500
1407	Phosphorylation	DMAEKSGSETPDGPL HHHHHCCCCCCCCCC	45.44	29550500
1409	Phosphorylation	AEKSGSETPDGPLSP HHHCCCCCCCCCCCC	28.51	29472430
1415	Phosphorylation	ETPDGPLSPGKMDDI CCCCCCCCCCCCCCC	34.44	29895711
1423	Phosphorylation	PGKMDDISPVQTDAL CCCCCCCCCCCCHHH	26.47	28066266
1450	Phosphorylation	LPFYAGLSPSGKLVA CCCEEEECCCCCEEE	18.99	26239621
1452	Phosphorylation	FYAGLSPSGKLVAYK CEEEECCCCCEEEEE	45.22	22942356
1486	Phosphorylation	AASRKPRTLLPSTSN CCCCCCCCCCCCCCC	40.97	25619855
1996	Phosphorylation	LREDARPYEYSYSTG HHCCCCCCEECCCCC	23.19	21149613
1998	Phosphorylation	EDARPYEYSYSTGSH CCCCCCEECCCCCCC	13.68	21149613
1999	Phosphorylation	DARPYEYSYSTGSHT CCCCCEECCCCCCCC	10.73	21149613
2000	Phosphorylation	ARPYEYSYSTGSHTD CCCCEECCCCCCCCC	14.89	21149613
2001	Phosphorylation	RPYEYSYSTGSHTDE CCCEECCCCCCCCCC	21.98	21149613
2002	Phosphorylation	PYEYSYSTGSHTDED CCEECCCCCCCCCCC	34.17	21149613
2004	Phosphorylation	EYSYSTGSHTDEDKD EECCCCCCCCCCCCC	24.25	29550500
2006	Phosphorylation	SYSTGSHTDEDKDGD CCCCCCCCCCCCCCC	42.66	29550500
2067	Phosphorylation	KVEPQEGSDNPENPD EECCCCCCCCCCCCC	33.20	29895711
2169	Phosphorylation	ISELLGKSGTIESGG HHHHHCCCCEEEECC	39.09	25777480
2171	Phosphorylation	ELLGKSGTIESGGVL HHHCCCCEEEECCEE	28.76	25777480
2174	Phosphorylation	GKSGTIESGGVLKTE CCCCEEEECCEEECC	36.68	25777480
2180	Phosphorylation	ESGGVLKTEDGSWSG EECCEEECCCCCCCC	34.84	25777480
2184	Phosphorylation	VLKTEDGSWSGISSS EEECCCCCCCCCCCC	30.32	25777480
2186	Phosphorylation	KTEDGSWSGISSSAA ECCCCCCCCCCCCCC	28.13	25777480
2189	Phosphorylation	DGSWSGISSSAAFSI CCCCCCCCCCCCEEE	23.05	25777480
2190	Phosphorylation	GSWSGISSSAAFSII CCCCCCCCCCCEEEC	23.29	25777480
2191	Phosphorylation	SWSGISSSAAFSIIP CCCCCCCCCCEEECC	19.47	25777480
2195	Phosphorylation	ISSSAAFSIIPRRAT CCCCCCEEECCCCCC	18.19	25777480
2206	Methylation	RRATKGRRGSRHFQG CCCCCCCCCCCHHCC	56.99	-
2210	Phosphorylation	KGRRGSRHFQGHLLL CCCCCCCHHCCCEEC	22.53	24719451
2213	Phosphorylation	RGSRHFQGHLLLPRE CCCCHHCCCEECCHH	16.68	24719451
2233	Phosphorylation	QQTKDGRSSAADFTV CCCCCCCCCCCCEEE	29.83	-
2239	Phosphorylation	RSSAADFTVLDLEDE CCCCCCEEEEECCCC	22.24	-
2338	Phosphorylation	SEKSRKVSLISSKLK CHHHHHHHHHHHHCC	24.03	28833060
2394	Phosphorylation	ITLGLLHSSKVSKSL HHHHHHCCCCCCHHH	31.65	26643407
2395	Phosphorylation	TLGLLHSSKVSKSLI HHHHHCCCCCCHHHH	26.74	26643407
2474	Phosphorylation	KRKKKLGSDEFCVSP HHHHHHCCCCCCCCC	44.39	25159016
2480	Phosphorylation	GSDEFCVSPRIGTQL CCCCCCCCCCCCCCC	15.05	25159016
2833	Phosphorylation	LPDVQEESESISPLL CCCHHHHHHCCCCHH	35.57	27566939
2835	Phosphorylation	DVQEESESISPLLLH CHHHHHHCCCCHHHH	37.33	21149613
2837	Phosphorylation	QEESESISPLLLHLE HHHHHCCCCHHHHCC	20.83	21149613
2849	Phosphorylation	HLEDDDFSENEKQLG HCCCCCCCCCHHHHC	46.65	21149613
2858	Phosphorylation	NEKQLGDTASEPDVL CHHHHCCCCCCCCEE	30.22	28066266
2860	Phosphorylation	KQLGDTASEPDVLKI HHHCCCCCCCCEEEE	52.32	27566939
2879	Phosphorylation	EIKDSLVSHRKSSDG HHHHHHHCCCCCCCC	23.91	22817900
2883	Phosphorylation	SLVSHRKSSDGGQST HHHCCCCCCCCCCCC	33.35	25266776
2884	Phosphorylation	LVSHRKSSDGGQSTS HHCCCCCCCCCCCCC	43.22	25266776
2899	Phosphorylation	GLPAEPESVSSPPIL CCCCCCCCCCCCCEE	37.71	26643407
2901	Phosphorylation	PAEPESVSSPPILHM CCCCCCCCCCCEEEC	46.54	26745281
2902	Phosphorylation	AEPESVSSPPILHMK CCCCCCCCCCEEECC	32.32	26745281
2998	Phosphorylation	LGNSGAPSSSSGK-- CCCCCCCCCCCCC--	42.17	25619855
2999	Phosphorylation	GNSGAPSSSSGK--- CCCCCCCCCCCC---	27.71	25619855
3000	Phosphorylation	NSGAPSSSSGK---- CCCCCCCCCCC----	47.66	25619855
3001	Phosphorylation	SGAPSSSSGK----- CCCCCCCCCC-----	53.18	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MGAP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MGAP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGAP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MGAP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.