dbPTM

P66B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	P66B_MOUSE
UniProt AC	Q8VHR5
Protein Name	Transcriptional repressor p66-beta
Gene Name	Gatad2b
Organism	Mus musculus (Mouse).
Sequence Length	594
Subcellular Localization	Nucleus speckle. Speckled nuclear localization requires both CR1 and CR2 regions..
Protein Description	Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A (By similarity). Targets MBD3 to discrete loci in the nucleus (By similarity). Plays a role in synapse development (By similarity)..
Protein Sequence	MDRMTEDALRLNLLKRSLDPADERDDVLAKRLKMEGHEAMERLKMLALLKRKDLANLEVPHELPTKQDGSGVKGYEEKLNGNLRPHGDNNRTAGRPGKENINDEPVDMSARRSEPDRGRLTPSPDIIVLSDNEASSPRSSSRMEERLKAANLEMFKGKGMEERQQLIKQLRDELRLEEARLVLLKKLRQSQLQKENVVQKTPVVQNAASIVQPSPAHVGQQGLSKLPSRPGAQGIEPQNMRTLQGHSVIRSATNTTLPHMLMSQRVIAPNPAQLQGQRGPPKPGIVRTTTPNMNPAISYQPQSSSSVPCQRTTSSAIYMNLASHIQPGTVNRVSSPLPSPSAMSDAANSQAAAKLALRKQLEKTLLEIPPPKPPAPLLHFLPSAANSEFIYMVGLEEVVQSVIDSQGKNCASLLRVEPFVCAQCRTDFTPHWKQEKNGKILCEQCMTSNQKKALKAEHTNRLKNAFVKALQQEQEIEQRLQQQAALSPTTAPAVSSVSKQETIMRHHTLRQAPQPQSSLQRGIPTSARSMLSNFAQAPQLSVPGGLLGMPGVNIAYLNTGIGGHKAPSLADRQREYLLDMIPPRSISQSISGQK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	O-linked_Glycosylation	---MDRMTEDALRLN ---CCCCHHHHHHHH	31.44	30059200
17	Phosphorylation	RLNLLKRSLDPADER HHHHHHHCCCCCHHH	35.22	22817900
52	Acetylation	MLALLKRKDLANLEV HHHHHHCHHHCCCCC	56.35	6569251
73	Acetylation	KQDGSGVKGYEEKLN CCCCCCCCCCHHHHC	60.34	6569083
113	Phosphorylation	VDMSARRSEPDRGRL CCCCCCCCCCCCCCC	48.18	27087446
121	Phosphorylation	EPDRGRLTPSPDIIV CCCCCCCCCCCCEEE	21.99	18388127
123	Phosphorylation	DRGRLTPSPDIIVLS CCCCCCCCCCEEEEC	29.93	24925903
130	Phosphorylation	SPDIIVLSDNEASSP CCCEEEECCCCCCCC	27.74	24925903
135	Phosphorylation	VLSDNEASSPRSSSR EECCCCCCCCCCCHH	34.40	24925903
136	Phosphorylation	LSDNEASSPRSSSRM ECCCCCCCCCCCHHH	31.23	27087446
139	Phosphorylation	NEASSPRSSSRMEER CCCCCCCCCHHHHHH	35.73	26745281
140	Phosphorylation	EASSPRSSSRMEERL CCCCCCCCHHHHHHH	24.20	26745281
141	Phosphorylation	ASSPRSSSRMEERLK CCCCCCCHHHHHHHH	36.57	26745281
190	Phosphorylation	LLKKLRQSQLQKENV HHHHHHHHHHHHCCC	26.82	27841257
194	Ubiquitination	LRQSQLQKENVVQKT HHHHHHHHCCCCCCC	60.90	27667366
200	Ubiquitination	QKENVVQKTPVVQNA HHCCCCCCCHHHCCH	43.09	-
209	Phosphorylation	PVVQNAASIVQPSPA HHHCCHHHHHCCCCC	22.38	-
214	Phosphorylation	AASIVQPSPAHVGQQ HHHHHCCCCCCCCCC	20.02	26745281
224	Phosphorylation	HVGQQGLSKLPSRPG CCCCCCCCCCCCCCC	38.68	26643407
228	Phosphorylation	QGLSKLPSRPGAQGI CCCCCCCCCCCCCCC	62.64	25338131
247	Phosphorylation	MRTLQGHSVIRSATN CCEECCCCHHHCCCC	26.51	29176673
288	Phosphorylation	PKPGIVRTTTPNMNP CCCCCCEECCCCCCC	24.91	26643407
289	Phosphorylation	KPGIVRTTTPNMNPA CCCCCEECCCCCCCC	29.68	26643407
290	Phosphorylation	PGIVRTTTPNMNPAI CCCCEECCCCCCCCC	16.44	27600695
318	Phosphorylation	RTTSSAIYMNLASHI CCCCCCHHHHHHHHC	4.62	-
334	Phosphorylation	PGTVNRVSSPLPSPS CCCCCCCCCCCCCHH	24.01	25521595
335	Phosphorylation	GTVNRVSSPLPSPSA CCCCCCCCCCCCHHH	27.83	27087446
339	Phosphorylation	RVSSPLPSPSAMSDA CCCCCCCCHHHCCHH	38.89	25521595
341	Phosphorylation	SSPLPSPSAMSDAAN CCCCCCHHHCCHHHH	40.72	25521595
344	Phosphorylation	LPSPSAMSDAANSQA CCCHHHCCHHHHHHH	24.66	27087446
349	Phosphorylation	AMSDAANSQAAAKLA HCCHHHHHHHHHHHH	19.23	25619855
463	Acetylation	AEHTNRLKNAFVKAL HHHHHHHHHHHHHHH	42.89	23806337
468	Ubiquitination	RLKNAFVKALQQEQE HHHHHHHHHHHHHHH	36.60	22790023
487	Phosphorylation	LQQQAALSPTTAPAV HHHHHCCCCCCHHHH	18.57	25521595
489	Phosphorylation	QQAALSPTTAPAVSS HHHCCCCCCHHHHHC	32.01	25521595
490	Phosphorylation	QAALSPTTAPAVSSV HHCCCCCCHHHHHCC	33.75	24925903
495	Phosphorylation	PTTAPAVSSVSKQET CCCHHHHHCCCHHHH	27.42	25619855
496	Phosphorylation	TTAPAVSSVSKQETI CCHHHHHCCCHHHHH	24.66	25619855
498	Phosphorylation	APAVSSVSKQETIMR HHHHHCCCHHHHHHH	30.48	25619855
518	Phosphorylation	QAPQPQSSLQRGIPT CCCCCCCHHHCCCCH	24.23	29899451
585	O-linked_Glycosylation	LDMIPPRSISQSISG HHHCCCCHHHHHCCC	32.16	30059200
587	Phosphorylation	MIPPRSISQSISGQK HCCCCHHHHHCCCCC	21.08	27600695
589	Phosphorylation	PPRSISQSISGQK-- CCCHHHHHCCCCC--	16.36	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of P66B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of P66B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of P66B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NANOG_MOUSE	Nanog	physical	18454139

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of P66B_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-121 AND SER-123, ANDMASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-121 AND SER-123, ANDMASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-121; SER-123; SER-130AND SER-136, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-487, AND MASSSPECTROMETRY.	15345747 [Abstract]