ORC1_MOUSE - dbPTM
ORC1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ORC1_MOUSE
UniProt AC Q9Z1N2
Protein Name Origin recognition complex subunit 1
Gene Name Orc1
Organism Mus musculus (Mouse).
Sequence Length 840
Subcellular Localization Nucleus.
Protein Description Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity)..
Protein Sequence MPSYLTRQKTRQTFSWVGRPLPNRKQFQQMYREICMKINDGSEIHIKVGQFVLIQGEDNKKPYVAKLIELFQNGAEVPPKKCARVQWFVRFLEIPVSKRHLLGRSPPAQEIFWYDCSDWDNKINVETIIGPVQVVALAPEEVIPVDQKSEETLFVKLSWNKKDFAPLPPEVLAALREQEDSPEWQKPLKAKIKNVKSPARNTTEQEVKGIKSNHSTSKFHQTPANIVIPNAKKSLELDGLGFTRKPNTRWSKKSSCDSLDYQKTSKRRAAFSETTSPPKKPNKPREIKPSSALETRVKNGQTQPFCAKSSVVLRARNPAMTTTKLGVDNTLSPIRNGLRSSVVPSGGLTPVYIRRKAKEQETHKEPIRTSRVHRKSSLLTLKRIRQQLCLLDGDDRDQEEEESVDSESEEEDEFISSLPTRNSLGQSRTRQTPSKSPQKNPKPRTPHRATPQIRDRNLAVQEPASALEEARLRLHVSAVPDSLPCREQEFQDIYSFVESKLLDGTGGCMYISGVPGTGKTATVHEVIRCLQQAAETDDVPPFQYVEVNGMKLTEPHQVYVQILKKLTGQKATANHAAELLAKQFCGQGSQKETTVLLVDELDLLWTHKQDVMYNLFDWPTHKGAHLIVLTIANTMDLPERIMMNRVSSRLGLTRMSFQPYSHSQLKQILVSRLRNLRAFEDDAIQLVARKVAALSGDARRCLDICRRATEICELSHLRGDSLSLVTVAHLMEAIDEMFSSSYITAIKNSSVVEQSFLRAIIAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSRLGSCRLLLVEPSRNDLLLRVRLNVSQNDVLFALKEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MPSYLTRQKTRQT
--CCCCCCCHHCCCC		23.87-
181PhosphorylationALREQEDSPEWQKPL
HHHHCCCCHHHHHCH		24.7826745281
197PhosphorylationAKIKNVKSPARNTTE
HHHHCCCCCCCCCCH		21.3627600695
202PhosphorylationVKSPARNTTEQEVKG
CCCCCCCCCHHHHHH		26.5926745281
203PhosphorylationKSPARNTTEQEVKGI
CCCCCCCCHHHHHHH		38.9426745281
233AcetylationIVIPNAKKSLELDGL
EECCCCCCCEECCCC		58.8422902405
234PhosphorylationVIPNAKKSLELDGLG
ECCCCCCCEECCCCC		26.7728066266
254PhosphorylationNTRWSKKSSCDSLDY
CCCCCCCCCCCCCCC		39.6829550500
255PhosphorylationTRWSKKSSCDSLDYQ
CCCCCCCCCCCCCCH		30.7225159016
258PhosphorylationSKKSSCDSLDYQKTS
CCCCCCCCCCCHHHH		27.7125159016
274PhosphorylationRRAAFSETTSPPKKP
HHHCCCCCCCCCCCC		31.2325367039
275PhosphorylationRAAFSETTSPPKKPN
HHCCCCCCCCCCCCC		34.8728066266
276PhosphorylationAAFSETTSPPKKPNK
HCCCCCCCCCCCCCC		46.7728066266
290PhosphorylationKPREIKPSSALETRV
CCCCCCCCCCHHHHH		24.2022871156
291PhosphorylationPREIKPSSALETRVK
CCCCCCCCCHHHHHH		45.4622871156
295PhosphorylationKPSSALETRVKNGQT
CCCCCHHHHHHCCCC		41.4322871156
321PhosphorylationRARNPAMTTTKLGVD
EECCCCCCCEECCCC		33.1621454597
323PhosphorylationRNPAMTTTKLGVDNT
CCCCCCCEECCCCCC		18.3321454597
330PhosphorylationTKLGVDNTLSPIRNG
EECCCCCCCCHHHCC		24.9324453211
332PhosphorylationLGVDNTLSPIRNGLR
CCCCCCCCHHHCCCC		19.0826824392
345PhosphorylationLRSSVVPSGGLTPVY
CCCCCCCCCCCCHHH		33.6126643407
349PhosphorylationVVPSGGLTPVYIRRK
CCCCCCCCHHHHHHH		17.6224453211
352PhosphorylationSGGLTPVYIRRKAKE
CCCCCHHHHHHHHHC		7.0126643407
376PhosphorylationTSRVHRKSSLLTLKR
CCHHCHHHHHHHHHH		26.6128833060
377PhosphorylationSRVHRKSSLLTLKRI
CHHCHHHHHHHHHHH		30.3622942356
380PhosphorylationHRKSSLLTLKRIRQQ
CHHHHHHHHHHHHHH		35.2121454597
436PhosphorylationTRQTPSKSPQKNPKP
CCCCCCCCCCCCCCC		36.5828066266
445PhosphorylationQKNPKPRTPHRATPQ
CCCCCCCCCCCCCHH		31.7925266776
450PhosphorylationPRTPHRATPQIRDRN
CCCCCCCCHHHHCCC		18.7125266776
829PhosphorylationLRVRLNVSQNDVLFA
EEEEECCCCCCEEEE		23.3825293948
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ORC1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ORC1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ORC1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ORC3_HUMANORC3physical
20360068
LRWD1_HUMANLRWD1physical
20360068
ORC1_HUMANORC1physical
20360068
ORC5_HUMANORC5physical
20360068
ORC2_HUMANORC2physical
20360068
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ORC1_MOUSE

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Related Literatures of Post-Translational Modification

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